“…Hyperhomocysteinemia is an independent risk factor for atherosclerosis, stroke, CVD [96,97], and endothelial dysfunction [98]. Accordingly, several studies have reported the correlation between total homocysteine concentration and FMD [99], cIMT [100], and cfPWV [101]. Indeed, high homocysteine plasma levels presumably affect NO bioavailability and impair endothelialdependent vasodilation [102,103].…”