The association of human leukocyte antigen polymorphisms with disease severity and latency period in patients with silicosis

Doğan, Hasan Serkan; Akgün, Metin; Araz, Ömer; Uçar, Elif Yılmazel; Yörük, Özgür; Diyarbakir, Eda; Atis, Omer; Akdemir, Fatma; Acemoğlu, Hamit; Pirim, İbrahim

doi:10.1186/2049-6958-9-17

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…Patients with silicosis due to denim sandblasting were also reported to have higher serum lactate dehydrogenase that showed a significant correlation with the radiological extent of disease and pulmonary function tests 26 . Autoimmune response may contribute significantly to silicosis development among sandblasters, more specifically, human leukocyte antigen (HLA) is linked with the severity of silica-induced lung disease but not with the progression time of the disease 27 . Co-occurrence of pulmonary tuberculosis and tuberculous meningitis were also observed in denim sandblasters with silicosis 28 .…”

Section: Denim Sandblastingmentioning

confidence: 99%

New Occupational Exposures with Respiratory Effects

Moitra¹,

Haldar²

2021

BRN

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Occupational exposure is one of the major risk factors for lung diseases globally. Although the aetiology and the course of major occupational lung diseases are well understood, the nature of lung diseases caused by new agents is still not well evaluated. The rise of interstitial and malignant lung diseases due to occupational exposures has caught global attention because either the causal agents are novel and the mode of action is poorly understood, or classical exposures have reappeared in a newer way, or the control measures are not implemented properly. With the introduction of new and innovative technologies, new agents such as indium compounds, diketones, nanomaterials, and physical processes such as hydraulic fracking are being introduced with substantially high deliberating effects on the workers' health. In this review, we summarise some new occupational exposures contributing to respiratory diseases and provide some recommendations for reducing the burden of occupational lung diseases.

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Section: Denim Sandblastingmentioning

confidence: 99%

New Occupational Exposures with Respiratory Effects

Moitra¹,

Haldar²

2021

BRN

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“…Importantly, gene-environment interactions related to these environmental exposures likely impact disease susceptibility. For example, there is increased severity of lung silicosis in persons with HLA-DR4 [ 26 ]. Moreover, a history of military burn pit and waste exposures in veterans with RA and the shared epitope has been linked to serum RA autoantibody levels [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Increased susceptibility to organic dust exposure-induced inflammatory lung disease with enhanced rheumatoid arthritis-associated autoantigen expression in HLA-DR4 transgenic mice

et al. 2022

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Immunogenetic as well as environmental and occupational exposures have been linked to the development of rheumatoid arthritis (RA), RA-associated lung disease, and other primary lung disorders. Importantly, various inhalants can trigger post-translational protein modifications, resulting in lung autoantigen expression capable of stimulating pro-inflammatory and/or pro-fibrotic immune responses. To further elucidate gene-environment interactions contributing to pathologic lung inflammation, we exploited an established model of organic dust extract (ODE) exposure with and without collagen-induced arthritis (CIA) in C57BL/6 wild type (WT) versus HLA-DR4 transgenic mice. ODE-induced airway infiltration driven by neutrophils was significantly increased in DR4 versus WT mice, with corresponding increases in bronchoalveolar lavage fluid (BALF) levels of TNF-⍺, IL-6, and IL-33. Lung histopathology demonstrated increased number of ectopic lymphoid aggregates comprised of T and B cells following ODE exposure in DR4 mice. ODE also induced citrullination, malondialdehyde acetaldehyde (MAA) modification, and vimentin expression that co-localized with MAA and was enhanced in DR4 mice. Serum and BALF anti-MAA antibodies were strikingly increased in ODE-treated DR4 mice. Coupling ODE exposure with Type II collagen immunization (CIA) resulted in similarly augmented pro-inflammatory lung profiles in DR4 mice (relative to WT mice) that was accompanied by a profound increase in infiltrating lung CD4+ and CD8+ T cells as well as CD19+CD11b+ autoimmune B cells. Neither modeling strategy induced significant arthritis. These findings support a model in which environmental insults trigger enhanced post-translational protein modification and lung inflammation sharing immunopathological features with RA-associated lung disease in the selected immunogenetic background of HLA-DR4 mice.

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Denim production and silicosis

Akgün

2016

Current Opinion in Pulmonary Medicine

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The association of human leukocyte antigen polymorphisms with disease severity and latency period in patients with silicosis

Cited by 4 publications

References 19 publications

New Occupational Exposures with Respiratory Effects

New Occupational Exposures with Respiratory Effects

Increased susceptibility to organic dust exposure-induced inflammatory lung disease with enhanced rheumatoid arthritis-associated autoantigen expression in HLA-DR4 transgenic mice

Denim production and silicosis

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