The Association of Hyperestrogenemia With Coronary Thrombosis in Men

Abstract

Both hyperestrogenemia and hypotestosteronemia have been reported in association with myocardial infarction (MI) in men. It was previously observed that the serum testosterone concentration correlated negatively with the degree of coronary artery disease (CAD) in men who had never had a known MI. The present study investigated the relationship of sex hormone levels to the thrombotic component of MI by comparing these levels in 18 men who had had an MI (ie, thrombosis) and 50 men with no history of MI (ie, no thrombosis) whose degree of CAD was in the same range. The mean degree of CAD, age, and body mass index in these two groups was not significantly different. The mean serum estradiol level in the men who had had an MI (38.5 +/- 8.8 pg/mL) was higher (P = .002) than the level in the men who had not had an MI (31.9 +/- 7.1 pg/mL). The mean levels of testosterone, free testosterone, sex hormone-binding globulin, insulin, dehydroepiandrosterone sulfate, cholesterol, HDI, cholesterol, and systolic and diastolic blood pressure did not differ significantly. Estradiol was the only variable measured that showed a significant relationship to MI (P < .003 by multivariate logistic regression). These findings suggest that hyperestrogenemia may be related to the thrombosis of MI.

Bio-Available Testosterone Levels Fall Acutely Following Myocardial Infarction in Men: Association With Fibrinolytic Factors

“…Lower baseline testosterone levels were associated with complications following myocardial infarction. These findings are in keeping with previous data suggesting a link between hyperoestrogenaemia and coronary thrombosis in men [26] and an association of low testosterone levels with risk factors for acute myocardial infarction. [3] Plasma levels of both total and bio-available testosterone (but not 17b-estradiol or DHEAS) fell transiently in the first 24 hours after myocardial infarction.…”

Serum estradiol and risk of stroke in elderly men

“…In another case-control study of coronary thrombosis, blood samples were taken at the time of angiography. 3 While the timing of the hyperestrogenemia was again uncertain, estrogen was elevated in the cases of thrombosis, and it was the only risk factor significantly related to a thrombotic event.…”

Endogenous Sex Hormones and Cardiovascular Disease in Men

“…Up to 1996, they retrieved one randomized intervention trial (57) and eight prospective (58 -65) and 30 cross-sectional studies (11, 14, 44, 66 -92). More recently, additional studies have been published and are summarized here (93)(94)(95)(96)(97)(98). Of 33 cross-sectional studies, 21 reported lower concentrations of T, BT, and/or DHEA(-S) in patients with CHD than in healthy men (14, 66, 69 -76, 79 -86, 93, 96, 98).…”