The association of intramammarian arterial calcifications detected on mammography with coronary artery disease and its risk factors

Abstract

Aim of the study: To evaluate the association of intramammarian arterial calcifications seen on mammography with coronary artery disease and its risk factors and to discuss intramammarian arterial calcifications value as a predictor of coronary artery disease. Material and methods: Mammography was performed on 55 women over 40 years of age who have undergone coronary angiography and have not had a mammography in the past year. Coronary angiography results, coronary artery disease risk factors and intramammarian arterial calcifications are evaluated. Results: The prevalance of intramammarian arterial calcifications was 41.8%. A significant relationship between intramammarian arterial calcifications and coronary artery disease was indicated (OR 10,8, 95% CI 3,02-38,59). The positive predictive value and negative predictive value of intramammarian arterial calcifications for coronary artery disease was 78.3% and 75% respectively. Also advancing age was found relevant with these calcifications (OR 1,15, 95% CI 1,05-1,25). Conclusion:The results support the present literature and suggest that mammography, already widely in use as a screening tool among women over 40, may be used simultaneously in coronary artery disease risk assessment. These results should be confirmed by further larger group controlled studies.

Evaluation of mammography detected breast arterial calcifications as a predictor of coronary cardiac risk

“…Also advancing age was detected to be relevant with these calcifications (OR 1.15, 95% Cl 1.05-1.25). The idea that the mammography was in use as a screening tool among women over 40 and could be used also in coronary artery disease risk assessment was supported by the results in the present literature which should be confirmed by further larger group controlled studies [15], compared with our study The 100 patients were divided into two groups according to age: 1st group, age ranging from 40 to 60 years; 2nd group, age ranging from 61 to 80 years which showed a correlation between BAC and CAD in the 2nd group only with a significant p value = 0.022 less, there was an increase in the mean age among BACpositive cases in both age groups but it was more significant in 1st group with a p value < 0.001 while in the 2nd group, the mean age in BAC-positive cases was 68.5 and in BAC-negative cases was 67.3 giving an insignificant p value 0.605. There was no significant association between BAC and risk factors in both age groups with insignificant p values.…”

“…According to Hekimoğlu et al 2012, who was aiming to discuss intramammarian arterial calcifications value in the prediction of coronary artery disease, mammography was done on 55 women over 40 years of age who do coronary angiography and did not have a mammography in the past year. Coronary angiography results, intramammarian arterial calcifications, and coronary artery disease risk factors were all evaluated.…”

No Association Between Left-Breast Radiation Therapy or Breast Arterial Calcification and Long-Term Cardiac Events in Patients with Breast Cancer

“…8 Similar to prior reports, preexisting cardiovascular disease, increased age, hypertension, and diabetes were positively associated with an increased prevalence of BAC; however, in contrast to prior studies with smaller patient populations or shorter follow-up, neither BAC nor BAC plus laterality of breast RT was significantly associated with subsequent cardiovascular events. [14][15][16][17] Our study is limited by its retrospective cross-sectional nature, the lack of data on family history, unknown mortality rate and mortality reasons, low response rate, and follow-up time (mean 7.5 years, range 3-24 years). Additionally, 9.5% of women underwent mastectomy, which may impact the identification of BAC after breast cancer treatment.…”

Prevalence of Coronary Artery Disease Evaluated by Coronary CT Angiography in Women with Mammographically Detected Breast Arterial Calcifications

“…Our literature review yielded nine studies that have investigated the relationship between BAC and catheter coronary angiography, with four studies demonstrating a positive association [ 18 ], [ 19 ], [ 24 ], [ 25 ]; a mixed relationship was demonstrated in two studies [ 17 ], [ 7 ]. Three studies, however, disputed existence of this relationship [ 20 ], [ 16 ], [ 26 ], postulating that BAC has the strongest association with increasing age.…”