The Association of Matrix Metalloproteinase-1 Promoter Polymorphisms with Breast Cancer

Abstract

Abstract. Background For many years, breast cancer has been the most common malignancy and the leading cause of female cancer mortality all over the world (1). According to the most updated report about burden of disease trends, cancers overall have increased by 34% during 199-2015 while breast cancer related deaths globally have increased to 45%, a much higher level than average overall cancers (1). In Taiwan, breast cancer has the highest incidence and is ranked as the fourth leading cause of mortality among Taiwanese women (2). From the viewpoint of epidemiology, the risk factors of breast cancer in Taiwan included high caloric intake, highfat diets, early menarche, late menopause, obesity, high levels of stress, and exposure to environmental pollutants (3). Since, the prevalence and mortality rates are both very high in Taiwan and the world, to figure out feasible molecular markers for early detection and prognosis prediction of breast cancer, especially the subtype of triple negative breast cancer (TNBC), are in urgent need.The matrix metalloproteinases (MMPs), which are also called matrixins, are a group of enzymes involved in tumor progression such as proliferation, invasion and metastasis (4, 5). In the literature, there are a few papers indicating that some MMP polymorphic genotypes, especially those 487

Matrix Metalloproteinase Gene Polymorphisms Are Associated with Breast Cancer in the Caucasian Women of Russia

“…The following supporting information can be downloaded at: . References [ 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 ] are cited in the supplementary materials.…”

Contribution ofMatrix Metalloproteinase-1Genotypes to Colorectal Cancer in Taiwan

“…In a meta-analysis investigating more than 38,000 subjects, the results also indicated that the genotypes of MMP-1 rs1799750 may be associated with colorectal, head and neck and renal cancer risk (31). However, in other types of cancers, the genotypes of MMP-1 rs1799750 may not directly contribute to susceptibility determination (17,(32)(33)(34)(35), which indicated that the MMP-1 rs1799750 genotypes may be indirectly involved in carcinogenesis. The detailed mechanisms of how MMP-1 rs1799750 genotypes interact with other molecules leading to CRC need further investigation.…”

Association of Matrix Metalloproteinase-1 Genotypes With Bladder Cancer Risk

“…In the literature, associations of MMP1 genotypes have been examined among many types of cancer, such as lung (32,33), breast (34)(35)(36), oral (37), colorectal (38,39), gastric (40)(41)(42), endometrial (43), cervical (44,45), prostate (17,46), and ovarian (47,48), in addition to bladder cancer (49)(50)(51)(52). Although there were several studies investigating the association of MMP1 genotypes with bladder cancer, the results were inconclusive and the total sample size is far from convincing, which we discuss later.…”