The association of matrix metalloproteinase-9 promoter polymorphisms with gastric cancer risk: a meta-analysis

Peng, Ziheng; Jia, Jinhai; Gong, Wenjian; Gao, Xuehan; Ma, Pelosi; Jin, Zhe; Fan, Yue; Li, Yanchu; Zhang, Xiaolin

doi:10.18632/oncotarget.20931

Cited by 5 publications

(4 citation statements)

References 35 publications

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“…Most data confirming the involvement of these polymorphisms in the formation of malignant tumors were obtained for the rs1799750 allele of the MMP1 gene. This polymorphism was shown to be associated with cancer of the esophagus (esophageal adenocarcinoma) [25][26][27][28] and stomach cancer [29][30][31][32]. The study of Okada et al [33] showed the association between rs17576 MMP9 and stomach cancer both independently and within the CAA rs3918242-rs17576-rs17577 MMP9 haplotype.…”

Section: Polymormentioning

confidence: 99%

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Gender-Specific Features of Associations of Polymorphism of Matrix Metalloproteinase Genes with the Development of Peptic Ulcer Disease in the Population of the Central Chernozem Region of Russia

2021

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Gender-specific features of associations of functionally significant polymorphic loci of matrix metalloproteinase genes with the development of peptic ulcer disease (PUD) in the population of the European part of Russia were studied. The study included 305 men (patients with PUD-188, control group-117) and 441 women (patients with PUD-211, control group-230). Ten functionally significant polymorphic loci of matrix metalloproteinase genes were genotyped: rs1799750 MMP1, rs243865 MMP2, rs679620 MMP3, rs1940475 MMP8, rs3918242, rs3918249, rs17576, rs3787268, rs2250889, rs17577 of the MMP9 gene. Associations of polymorphic loci of MMP genes with PUD were studied by logistic regression (dominant, recessive, and additive genetic models of allele interaction were evaluated). It was found that alleles C rs3918249 (OR = 1.61, p perm = 0.048) and G rs17576 (OR = 1.48-2.08, p perm ≤ 0.042) of the MMP9 gene were risk factors for the occurrence of PUD in men. In women, the 2G rs1799750 allele of the MMP1 gene had a protective value for the development of the disease (OR = 0.74, p perm = 0.047). Polymorphic loci associated with PUD in men and women exhibit pronounced epigenetic effects (they affect the affinity of DNA motifs for various transcription factors, are located in the region of promoters and enhancers in the stomach and duodenum, and are associated with gene expression in various parts of the digestive system). Gender-specific features of associations of polymorphism of MMP genes with the development of PUD were revealed: rs3918249 and rs17576 of the MMP9 gene determine the susceptibility to the development of PUD in men, and rs1799750 of the MMP1 gene determines the susceptibility in women.

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Section: Polymormentioning

confidence: 99%

“…Numerous studies showed the connection between the MMP1 and MMP9 polymorphic loci and the development of oncological diseases of the digestive system [25][26][27][28][29][30][31][32][33]. Most data confirming the involvement of these polymorphisms in the formation of malignant tumors were obtained for the rs1799750 allele of the MMP1 gene.…”

Section: Polymormentioning

confidence: 99%

Gender-Specific Features of Associations of Polymorphism of Matrix Metalloproteinase Genes with the Development of Peptic Ulcer Disease in the Population of the Central Chernozem Region of Russia

2021

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“…The discussed polymorphism was analyzed not only in the context of the central nervous system diseases Certain reports indicate its association with cardiovascular diseases ( Mittal et al, 2014 ), prostate cancer ( Kiani et al, 2020 ), gastric cancer ( Peng et al, 2017 ), T-cell acute lymphoblastic leukemia ( Lin et al, 2017 ), autoimmune diseases ( Li et al, 2017 ), and chronic periodontitis ( Mashhadiabbas et al, 2019 ). For example, the allele T results in the increase in MMP-9 levels in the serum of cardiovascular patients, and it is associated with a nearly doubled risk of cardiac death and significantly lower survival rates ( Blankenberg et al, 2003 ).…”

Section: Introductionmentioning

confidence: 99%

“…In the case of neoplasms, e.g., people with CT + TT genotype, who additionally had diabetes and smoked, were at a 3.52 times higher risk of developing prostate cancer ( Kiani et al, 2020 ). In the case of gastric cancer, the meta-analysis showed that carriers of the TT genotype were at 1.666 times higher risk of that cancer when compared to carriers of the CC genotype ( Peng et al, 2017 ). The most recent publications also report the relationship between the MMP-9-1562C/T polymorphism and the risk of pre-eclampsia or breast cancer and its aggressiveness ( Gannoun et al, 2021 ; Bartnykaitė et al, 2022 ; Huang et al, 2022 ; Yan et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Does the functional polymorphism-1562C/T of MMP-9 gene influence brain disorders?

Pabian‐Jewuła

Rylski

2023

Front. Cell. Neurosci.

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Metalloproteinase-9 (MMP-9) is one of the most strongly expressed matrix metalloproteinases (MMPs) in the brain. The MMP-9 activity in the brain is strictly regulated, and any disruptions in this regulation contribute to a development of many disorders of the nervous system including multiple sclerosis, brain strokes, neurodegenerative disorders, brain tumors, schizophrenia, or Guillain-Barré syndrome. This article discusses a relationship between development of the nervous system diseases and the functional single nucleotide polymorphism (SNP) at position -1562C/T within the MMP-9 gene. A pathogenic influence of MMP-9-1562C/T SNP was observed both in neurological and psychiatric disorders. The presence of the allele T often increases the activity of the MMP-9 gene promoter and consequently the expression of MMP-9 when compared to the allele C. This leads to a change in the likelihood of an occurrence of diseases and modifies the course of certain brain diseases in humans, as discussed below. The presented data indicates that the MMP-9-1562C/T functional polymorphism influences the course of many neuropsychiatric disorders in humans suggesting a significant pathological role of the MMP-9 metalloproteinase in pathologies of the human central nervous system.

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Activities and polymorphisms of MMP-2 and MMP-9, smoking, diabetes and risk of prostate cancer

et al. 2020

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The association of matrix metalloproteinase-9 promoter polymorphisms with gastric cancer risk: a meta-analysis

Abstract: Conclusions: Our meta-analysis results demonstrated that MMP-9-1562C/T promoter polymorphisms increase the risk of developing gastric cancer.

Cited by 5 publications

References 35 publications

Gender-Specific Features of Associations of Polymorphism of Matrix Metalloproteinase Genes with the Development of Peptic Ulcer Disease in the Population of the Central Chernozem Region of Russia

Gender-Specific Features of Associations of Polymorphism of Matrix Metalloproteinase Genes with the Development of Peptic Ulcer Disease in the Population of the Central Chernozem Region of Russia

Does the functional polymorphism-1562C/T of MMP-9 gene influence brain disorders?

Activities and polymorphisms of MMP-2 and MMP-9, smoking, diabetes and risk of prostate cancer

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