The association of mean platelet volume levels with hypertensive retinopathy

Çoban, Erkan; Adanir, Haydar; Bilgin, Deniz

doi:10.1080/09537100701230451

Cited by 22 publications

(27 citation statements)

References 27 publications

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“…Whereas the cell differentials and platelet counts were in the normal range (290,000 to 650,000 platelets/μl) for rabbits immunized with the MAP-19mer (Penelope and Patricia), rabbits immunized with the MAP-14mer had low or borderline low normal platelet counts of 187,000/μl (Alice) and 290,000/μl (Rosita) after the third boost, which remained below normal (250,000/μl) in only one rabbit (Alice) at bleed-5; however, none of the rabbits were anemic. The mean platelet volume (MPV) was 3–fold higher in the rabbit with the lowest platelet counts (Alice), which is consistent with platelet activation and platelet destruction (immune thrombocytopenia) and new platelet production (Coban et al, 2008). Adherence of platelets on neutrophils and monocytes, known as satellitism, was observed (not shown), which is frequently associated with sporadic thrombocytopenia (Lazo-Langner et al, 2002).…”

Section: Resultssupporting

confidence: 58%

“…Platelet depletion and increased MPV reflect the state of thrombogenesis (Hekimsoy et al, 2004). High MPV is associated with low platelet counts due to platelet destruction (immune thrombocytopenia) and platelet activation (Coban et al, 2008, Sullivan et al, 1995). Increase in MPV occurs in patients with metabolic syndrome, stroke and diabetes mellitus (Zuberi et al, 2008), contributing to the increased vascular complications and endothelial cell dysfunction observed (Hekimsoy et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

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A putative role for platelet-derived PPARγ in vascular homeostasis demonstrated by anti-PPARγ induction of bleeding, thrombocytopenia and compensatory megakaryocytopoiesis

Simpson-Haidaris

Seweryniak

Spinelli

et al. 2010

Journal of Biotechnology

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Widely known for its role in adipogenesis and energy metabolism, PPARγ also plays a role in platelet function. To further understand functions of platelet-derived PPARγ, we produced rabbit polyclonal (PoAbs) and mouse monoclonal (MoAbs) antibodies against PPARγ 14mer/19mer peptide-immunogens. Unexpectedly, our work produced two key findings. First, MoAbs but not PoAbs produced against PPARγ peptide-immunogens displayed antigenic crossreactivity with highly conserved PPARα and PPARβ/δ. Similarly, Santa Cruz PoAb sc-7196 was monospecific for PPARγ while MoAb sc-7273 crossreacted with PPARα and PPARβ/δ. Second, immunized rabbits and mice exhibited unusual pathology including cachexia, excessive bleeding, and low platelet counts leading to thrombocytopenia. Spleens from immunized mice were fatty, hemorrhagic and friable. Although passive administration of anti-PPARγ PoAbs failed to induce experimental thrombocytopenia, megakaryocytopoiesis was induced 4-8-fold in mouse spleens. Similarly, marrow megakaryocytopoiesis was enhanced 1.8-4-fold in immunized rabbits. These peptide-immunogens are 100% conserved in human, rabbit and mouse; thus, immune-mediated platelet destruction via crossreactivity with platelet-derived PPARγ likely caused bleeding, thrombocytopenia, and compensatory megakaryocytopoiesis. Such overt pathology would cause significant problems for large-scale production of anti-PPARγ PoAbs. Furthermore, a major pitfall PJS-H developed the concept, designed and performed experiments, analyzed data, prepared figures and wrote the manuscript; KES designed and performed experiments, analyzed data and edited the paper; SLS, TMG-B, TIM, and SJP performed experiments and edited the manuscript; PJS and RPP made substantial contributions to interpretation of the data, critical revisions to the manuscript for important intellectual content and supplied critical reagents.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript associated with MoAb production against closely related molecules is that monoclonicity does not guarantee monospecificity, an issue worth further scientific scrutiny.

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Section: Resultssupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

A putative role for platelet-derived PPARγ in vascular homeostasis demonstrated by anti-PPARγ induction of bleeding, thrombocytopenia and compensatory megakaryocytopoiesis

Simpson-Haidaris

Seweryniak

Spinelli

et al. 2010

Journal of Biotechnology

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“…These findings concur with the result of a previous study. 8 Thus, it is a highly relevant finding that MPV in patients with hypertension is significantly higher than in normotensive control subjects. 9 There is growing evidence that increased platelet activation, a common finding in hypertension, may contribute significantly to these complications with serious vascular atheroscerotic diseases, such as stroke, coronary artery disease, and retinopathy.…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume as an indicator of severity of hypertensive retinopathy in hypertensive subjects

et al. 2017

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INTRODUCTIONHypertension is one of the most common worldwide diseases afflicting humans and is a major risk factor for stroke, myocardial infarction, vascular disease, and chronic kidney disease.Despite extensive research over the past several decades, the etiology of most cases of adult hypertension is still unknown, and control of blood pressure is suboptimal in the general population. Due to the associated morbidity and mortality and cost to society, preventing and treating hypertension is an important public health challenge. Fortunately, recent advances and trials in hypertension research are leading to an increased understanding of the pathophysiology of hypertension and the promise for novel pharmacologic and interventional treatments for this widespread disease.Hypertensive retinopathy represents the ophthalmic findings of end-organ damage secondary to systemic arterial hypertension. Although its name implies only retinal involvement, changes in both the choroid and the optic nerve are observed, depending on the chronicity and severity of the disease. Clinical changes from hypertensive choroidopathy are directly related to the release of endogenous vasoconstrictor agents during systemic hypertension. Platelets play a crucial role in the ABSTRACT Background: Hypertensive retinopathy (HR) represents the ophthalmic findings of end-organ damage secondary to systemic arterial hypertension. Platelets play a crucial role in the pathogenesis of atherosclerotic complications, contributing to thrombus formation or apposition after plaque rupture. The aim of our study was to investigate whether Mean platelet volume (MPV) is associated with the severity of hypertensive retinopathy in hypertensive patients. Methods: This cross-sectional study was conducted in Department of Medicine of SAMC and PGI, Indore. Total 250 adult hypertensive patients (BP >140/90 mm Hg or taking antihypertensive drugs) recruited for the study. Results: Of the 250 subjects, 158 (63.2%) were male and 92 (36.8%) were female. Elevated MPV >11.5 femtoliter was observed in 84 cases (33.6%). There was statistically significant relationship between the grade of retinopathy and elevated MPV in hypertensive subjects. (r = 0.52, P <0.001). Conclusions: We described a relation between MPV and HR (probably first time in Indian patients). Measurement of MPV is easy to establish and therefore might serve as a valuable predictor of a worse outcome in microvascular complications.

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“…7 The literature on the association between MPV and stroke is inconsistent 8,9 and may also relate to the use of different methods to assess MPV and the variable time points used for MPV measurement after stroke onset. 10 Moreover, emerging evidence has shown that known cardiovascular risk factors, such as smoking, 11 diabetes mellitus, 12 obesity 13 and hypertension, 14,15 are associated with MPV. Prehypertension, as defined by the Seventh Joint National Committee, 16 includes those with systolic blood pressure ranging 120-139 mm Hg or diastolic blood pressure ranging 80-89 mm Hg, is identified as a predictor for developing hypertension 17 and a stage where the primary prevention of hypertension is possible.…”

Section: Introductionmentioning

confidence: 99%

Increased platelet volume in a general population with prehypertension: a cross-sectional study of 80 545 participants from China

et al. 2012

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Mean platelet volume (MPV), an indicator of platelet activation, has been shown to be elevated in patients with hypertension. However, data available on the association between MPV level and prehypertension are limited. Prehypertension is also associated with an increase in cardiovascular morbidity and mortality. A cross-sectional study was performed among 80 545 standardized medical checkup participants X18 years in age without hypertension or diabetes in China between April 2009 and May 2010. Blood pressure was categorized as prehypertensive (systolic blood pressure, 120-140 mm Hg and/or diastolic blood pressure, 80 to 90 mm Hg, n ¼ 36 586) and normotensive (systolic blood pressure, o120 mm Hg and diastolic blood pressure, o80 mm Hg, n ¼ 43 959). Mean systolic blood pressure and the prevalence of prehypertension increased significantly with increasing MPV. After adjusting for demographics, body mass index, smoking and serum cholesterol, the odds ratio for prehypertension, when comparing the highest category of MPV (412.0 fl) with the lowest category (o10.1 fl), was 1.08 (95% confidence interval, 1.02-1.13; P for trend ¼ 0.014). This association persisted in separate analysis among men but not among women. In nonparametric models, the positive association between MPV and prehypertension appeared to be present across the full range of MPV, without any threshold effect. Increased MPV is associated with prehypertension in a large sample of Chinese adults that are free of cardiovascular disease and hypertension.

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The association of mean platelet volume levels with hypertensive retinopathy

Cited by 22 publications

References 27 publications

A putative role for platelet-derived PPARγ in vascular homeostasis demonstrated by anti-PPARγ induction of bleeding, thrombocytopenia and compensatory megakaryocytopoiesis

A putative role for platelet-derived PPARγ in vascular homeostasis demonstrated by anti-PPARγ induction of bleeding, thrombocytopenia and compensatory megakaryocytopoiesis

Mean platelet volume as an indicator of severity of hypertensive retinopathy in hypertensive subjects

Increased platelet volume in a general population with prehypertension: a cross-sectional study of 80 545 participants from China

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