The association of naevus lipomatosus with pilosebaceous abnormalities including fibrofolliculoma

Rapidly Growing Congenital Groin Mass

“…Adnexal structures are typically normal in appearance and dilated follicles and abortive hair germlike structures are frequently noted . Several reports have been published describing pilar abnormalities within NLS, including hypertrophic pilosebaceous units, perifollicular fibrosis, fibrofolliculomas, sebaceous trichofolliculomas, and folliculosebaceous cystic hamartomas . Some of the characteristic histologic features discussed above were prevalent in this case, including the abnormal presence of mature adipose tissue within the dermis, mild perifollicular fibrosis, and numerous dilated follicles (Figs.…”

“…It is unclear whether the mature adipocytes in NLS are predominantly derived from perivascular mesenchymal cells or vascular endothelial cells. Regardless, the presence of epithelial and mesenchymal dermal components suggests NLS could be more broadly categorized as a connective tissue hamartoma or nevus . No significant medical comorbidities, congenital defects, or genodermatoses have been associated with NLS.…”

Cylindroma with Stromal Adipose Tissue Metaplasia versus Arising in a Background of Nevus Lipomatosus

“…Lee et al [6] described cystically dilated hair follicles with infundibular keratinization lining. Similarly, Yun et al [7] described dilated follicular cysts, as well as hair follicles that formed anastomosing epithelial strands suggestive of fibrofolliculoma. Sakanoue et al [8] reported a case of NLS associated with a cystic follicular structure accompanied by sebaceous glands embedded in fibrous stroma, compatible with trichofolliculoma.…”

Nevus Lipomatosus Superficialis with a Folliculosebaceous Component: Report of 2 Cases

“…We consider both cases as examples of NLS with a folliculosebaceous component. A follicular component in an NLS is a very unusual event, which can clinically be suggested by the presence of umbilicated papules in the lesion [4]. …”

“…However, some cases of NLS with pilar anomalies have been reported, such as abortive hair germ-like structures [1], hypertrophic pilosebaceous units [2], perifollicular fibrosis [3], fibrofolliculomas [4], and folliculosebaceous cystic hamartomas (FSCHs) [5, 6]. …”