The association of neutrophil–lymphocyte ratio and platelet–lymphocyte ratio with retinal vein occlusion: a systematic review and meta‐analysis

Abstract

The neutrophil–lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR) are emerging haematological inflammatory biomarkers. However, their significance in retinal vein occlusion (RVO) and its subtypes, branch and central RVO (BRVO and CRVO, respectively), is uncertain. This systematic review and meta‐analysis aimed to clarify the association of NLR and PLR with RVO. We searched MEDLINE (Ovid), EMBASE (Ovid) and the Cochrane Library for studies investigating the association of NLR and PLR with RVO from inception to 2 December 2020. We used random‐effects inverse‐variance modelling to generate pooled effect measures. We used bivariate Bayesian modelling to meta‐analyse the ability of NLR and PLR to differ between individuals with and without RVO and performed meta‐regression and sensitivity analyses to explore inter‐study heterogeneity. Eight studies published encompassing 1059 patients were included for analysis. Both NLR and PLR were significantly elevated in RVO, with pooled mean differences of 0.63 (95% confidence interval (CI) 0.31–0.95) and 21.49 (95% CI 10.03–32.95), respectively. The pooled sensitivity, specificity and area under the Bayesian summary receiver operating characteristic curve were, respectively, 0.629 (95% credible interval (CrI) 0.284–0.872), 0.731 (95% CrI 0.373–0.934) and 0.688 (95% CrI 0.358–0.872) for NLR; and 0.645 (95% CrI 0.456–0.779), 0.616 (95% CrI 0.428–0.761) and 0.621 (95% CrI 0.452–0.741) for PLR. Mean and variability of age and diabetes mellitus prevalence partially explained between‐study heterogeneity. NLR and PLR are significantly elevated in RVO. Future research is needed to investigate the potential prognostic value and independence of these findings.

Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Their Variations as a Basis for a Prediction Model in Advanced NSCLC Patients Receiving Anlotinib

“…Previous studies have demonstrated that the systemic infection response plays a critical role in the symptom response [ 8 , 9 ]. Many clinical inflammation markers, such as neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR), can be easily measured via relatively inexpensive tests and with accurately reliable clinical results in several types of cancers and other diseases [ 10 – 17 ]. There have also been articles reporting that the predicting value of NLR and PLR in not only viable foe surgical treatment of early stage NSCLC but also in chemo-radiotherapy and immunotherapy of advanced NSCLC [ 13 , 18 – 20 ].…”

Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) are more prominent in retinal artery occlusion (RAO) compared to retinal vein occlusion (RVO)

“…Several studies have recently discovered different possible biomarkers for predicting RAO or RVO from normal blood analysis. The connection between NLR and RVO was revealed ( Table 1 ) [ 19 – 23 ]. Furthermore, the monocyte to high-density lipoprotein ratio (MHR), rather than PLR, may be a useful predictor for the development of RAO [ 24 – 26 ].…”

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“…Prior researches have looked at the effects of NLR and PLR on predicting RAO or RVO [19][20][21][22][23][24][25][26]43,49,50]. In some investigations, NLR has already been shown to be a unique marker for predicting RAO [24,26].…”

“…Several studies have recently discovered different possible biomarkers for predicting RAO or RVO from normal blood analysis. The connection between NLR and RVO was revealed (Table 1) [19][20][21][22][23]. Furthermore, the monocyte to high-density lipoprotein ratio (MHR), rather than PLR, may be a useful predictor for the development of RAO [24][25][26].…”