The association of neutrophil/lymphocyte ratio and platelet/lymphocyte ratio with clinical outcomes in geriatric patients with stage 3–5 chronic kidney disease

Tatar, Erhan; Mirili, Cem; Isikyakar, Tolgay; Yaprak, Mustafa; Guvercin, Guray; Özay, Emine; Aşçı, Gülay

doi:10.1080/17843286.2016.1159797

Cited by 32 publications

(32 citation statements)

References 29 publications

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“…Studies have reported a close association between the worsened prognosis and complications of cardiovascular, metabolic, malignant, and inflammatory diseases and NLR (Corriere et al, 2018;Li et al, 2017;Akbas et al, 2014;Ulu et al, 2013;Jiang et al, 2018;Polat et al, 2017;Uysal et al, 2016;Kalay et al, 2012;Xiao et al, 2014;Wei et al, 2014). In addition, NLR is stated to be a new inflammatory marker for cardiovascular risk and cardiac mortality (Uysal et al, 2016;Tatar et al, 2016). It has reported that NLR can be used as a parameter predicting mortality in end stage renal failure (Tatar et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

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Platelet Lymphocyte Ratio is Associated With Carotid Atherosclerosis in Hemodialysis Patients

Kaya¹,

Yaman²,

Karataş³

et al. 2019

Middle Black Sea Journal of Health Science

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Objective: We aimed to demonstrate whether there is a correlation between Platelet Lymphocyte Ratio (PLR) and carotid intima-media thickness (CIMT) which is an early marker of atherosclerosis in patients receiving dialysis where there is a chronic inflammatory process in the body. Methods: 53 patients receiving dialysis 3 days a week and 54 persons as the control group were included. The exclusion criteria were determined as infection, using drugs that increase or decrease the number of leukocytes such as steroids, antithyroid, chronic liver diseases, rheumatic disease, maling disease and prior cardiovascular or cerebrovascular diseases. Patients' age, gender, body mass index, hemogram and biochemical parameters were recorded. CIMT values were measured by Carotid Doppler examination. Results: When the two groups were compared; there was no significant difference between them in terms of age, gender, blood pressures, DM, ejection fractions, lipid levels. PLR, neutrophil-to-lymphocyte ratio (NLR) and CIMT were significantly higher (p=0.009, p<0.001, p<0.001; respectively) in the dialysis patients group. A positive correlation was found between CIMT and PLR, NLR (r=0.59 p<0.001, r=0.38, p=0.004). As a result of the linear regression analysis, PLR (B:0.714, 95%CI:3.425/14.393, p=0.002) and NLR were found as independent predictors in showing CIMT. Conclusion: PLR is independently associated with subclinical atherosclerosis assessed by CIMT in people with dialysis patients

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Section: Discussionmentioning

confidence: 99%

“…In addition, NLR is stated to be a new inflammatory marker for cardiovascular risk and cardiac mortality (Uysal et al, 2016;Tatar et al, 2016). It has reported that NLR can be used as a parameter predicting mortality in end stage renal failure (Tatar et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Platelet Lymphocyte Ratio is Associated With Carotid Atherosclerosis in Hemodialysis Patients

Kaya¹,

Yaman²,

Karataş³

et al. 2019

Middle Black Sea Journal of Health Science

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“…Tatar et al [30] found the basal NLR was an independent predictor of death in geriatric patients with stage 3–5 chronic kidney disease. Kocyigit et al [31] demonstrated that patients with a high NLR had worse prognosis and significantly faster progression to the dialysis compared with those with a low NLR.…”

Section: Discussionmentioning

confidence: 99%

High Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Mortality in Chronic Hemodialysis Patients

Xiong³

et al. 2017

Mediators of Inflammation

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The neutrophil-to-lymphocyte ratio (NLR) is a novel simple biomarker of inflammation. It has emerged as a predictor of poor prognosis in cancer and cardiovascular disease in general population. But little was known of its prognostic value in chronic hemodialysis (HD) patients. Here we investigated the association between NLR and cardiovascular risk markers, including increased pulse pressure (PP), left ventricular mass index (LVMI) and intima-media thickness (IMT), and mortality in HD patients. Two hundred and sixty-eight HD patients were enrolled in this study and were followed for 36 months. The primary end point was all-cause mortality and cardiovascular mortality. Multivariable Cox regression was used to calculate the adjusted hazard ratios for NLR on all-cause and cardiovascular survival. We pinpointed that higher NLR in HD patients was a predictor of increased PP, LVMI, and IMT; HD patients with higher NLR had a lower survival at the end of the study; furthermore, high NLR was an independent predictor of all-cause and cardiovascular mortality when adjusted for other risk factors. In conclusion, higher NLR in HD patients was associated with cardiovascular risk factors and mortality.

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“…NLR and PLR are current markers of interest for systemic inflammation (11)(12)(13). Data is limited in patients with cHepC.…”

Section: Discussionmentioning

confidence: 99%

“…Neutrophil lymphocyte ratio (NLR) and thrombocyte lymphocyte ratio (PLR) are used as markers of inflammation in various diseases including atherosclerotic heart and renal disease. They are more sensitive compared to total leukocyte counts (11)(12)(13). However, there are no data to confirm their use in cHepC patients.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Biomarkers and Liver Histopathology in Non-Uremic and Uremic Chronic Hepatitis C Patients

Tatar

Köse

Pala

et al. 2017

Acta Med. (Hradec Kralove, Czech Repub.)

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A B ST R AC T Background: The aim of this study is to investigate the association between hepatic activity index (HAI) and fibrosis score (FS) with inflammation biomarkers in non-uremic and uremic hepatitis C positive patients. Methods: Fifty chronic hepatitis C (cHepC) positive patients, having a liver biopsy were included in this study. Liver biopsies were scored according to modified ISHAC scoring system. 25 healthy controls of similar age and gender were also enrolled as control group. Serum YKL-40, neutrophil/lymphocyte ratio (NLR), thrombocyte/lymphocyte ratio (PLR), CRP and Immunoglobulin (IgG, A and M) levels were used to determine inflammation. AST to Platelet Ratio Index (APRI) score was also evaluated. According to biopsy findings patients were divided into 2 groups: low (0-2) and severe (3-6) FS. Results: Patients with cHepC had increased inflammation compared to the healthy controls. End-stage renal disease (ESRD) patients had higher levels of inflammation markers (NLR, IgG, CRP and YKL-40) and lower HCV RNA levels, HAI and FS compared to non-uremic patients. When patients were grouped into 2 according to FS as mild and severe, IgG (p < 0.001), YKL-40 (p = 0.02) levels and APRI score (p = 0.002) were significantly higher compared to mild FS (p = 0.002). YKL-40 levels (t value: 3.48; p = 0.001) and APRI score (t value: 4.57, p < 0.001) were found as independent associated with FS in non-uremic patients. However, in adjusted models, only APRI score (t value: 3.98, p = 0.002) was an independent associated with FS in ESRD patients. Conclusion: In non-uremic cHepC patients, YKL-40 levels and APRI score may be valuable markers of FS. In ESRD patients, there is not sufficient data for prediction of HAI and FS. In these patients, APRI score may provide better information. K E Y WO R D S APRI score; hepatitis C; end-stage renal disease; inflammation biomarkers; YKL-40; liver histopathology

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The association of neutrophil/lymphocyte ratio and platelet/lymphocyte ratio with clinical outcomes in geriatric patients with stage 3–5 chronic kidney disease

Abstract: The neutrophil/lymphocyte ratio predicts all-cause of mortality in geriatric patients with chronic kidney disease.

Cited by 32 publications

References 29 publications

Platelet Lymphocyte Ratio is Associated With Carotid Atherosclerosis in Hemodialysis Patients

Platelet Lymphocyte Ratio is Associated With Carotid Atherosclerosis in Hemodialysis Patients

High Neutrophil-to-Lymphocyte Ratio Predicts Cardiovascular Mortality in Chronic Hemodialysis Patients

Inflammatory Biomarkers and Liver Histopathology in Non-Uremic and Uremic Chronic Hepatitis C Patients

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