2015
DOI: 10.3109/0886022x.2015.1103654
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The association of oxidant–antioxidant status in patients with chronic renal failure

Abstract: Oxidative stress has been linked to disease progression, including chronic renal failure (CRF). The aim of the present study was to determine malondialdehyde (MDA) as a sign of lipid peroxidation, and to investigate the association between antioxidant activities and three trace elements, in 49 patients with CRF. The erythrocyte and plasma trace elements [selenium (Se), zinc (Zn), and copper (Cu)] and antioxidant defense levels were determined: glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase … Show more

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Cited by 28 publications
(36 citation statements)
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“…Reduced concentration of trace elements, such as Se, Cu and Zn lowers the activity of antioxidant enzymes (SOD, Gpx). Lowered concentration of trace elements was reduced is probably a result of insufficient intake, but also increased loss during high-flux haemodialysis/hemodiafiltration [10]. Also, because of the lack of vitamin C and vitamin E, the capacity of non-enzymatic antioxidative protection systems has been reduced [10].…”
Section: Introductionmentioning
confidence: 99%
“…Reduced concentration of trace elements, such as Se, Cu and Zn lowers the activity of antioxidant enzymes (SOD, Gpx). Lowered concentration of trace elements was reduced is probably a result of insufficient intake, but also increased loss during high-flux haemodialysis/hemodiafiltration [10]. Also, because of the lack of vitamin C and vitamin E, the capacity of non-enzymatic antioxidative protection systems has been reduced [10].…”
Section: Introductionmentioning
confidence: 99%
“…Nevertheless, during environmental stress and cell dysfunction, levels of ROS can increase dramatically and cause significant cellular damage in the body. Consequently, oxidative stress significantly contributes to the pathogenesis of different diseases, such as heart disease, inflammatory disease, cancer, diabetes mellitus, Alzheimer's disease, autism, and to the aging process (Figure 1) [3][4][5]. The chapter clarifies oxidative stress.…”
Section: Introductionmentioning
confidence: 99%
“…Oxidative stress refers to the imbalance between oxidants and antioxidants within the body due to antioxidant deficiency or increased reactive oxygen species (ROS), reactive nitrogen species (RNA), and reactive sulfur species (RSS) production, which lead to potential cellular damage [1,2]. ROS is a collective term that encompasses all highly reactive forms of oxygen, including free radicals.…”
Section: Introductionmentioning
confidence: 99%
“…[123] Antioxidants in fruits and vegetables may help to protect people from chronic disorders such as ischemic heart disease. [456] β-carotene, tocopherol, and vitamin C by inhibiting low-density lipoprotein oxidation can prevent atherosclerosis.…”
Section: Introductionmentioning
confidence: 99%