The association of polymorphisms of the vitamin D receptor gene with psoriasis in the Han population of northeastern China

Zhou, Xing; Xu, Lei; Li, Yuzhen

doi:10.1016/j.jdermsci.2013.08.014

Cited by 25 publications

(27 citation statements)

References 28 publications

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“…Vitamin D analogues have been used in psoriasis intervention alone or in combination with other treatments. The study on association of polymorphisms of the vitamin D receptor gene with psoriasis was recently performed on large sample size [26]. In the Han population of northeastern China, an association between one of the vitamin D receptor gene polymorphisms (ApaI) and psoriasis was identified, similar to previous studies based on small sample size in the Korean, Turkish, Croatian, or Egyptian population.…”

Section: Genetic Background Of Psoriasissupporting

confidence: 73%

Recent advances in atopic dermatitis and psoriasis: Genetic background, barrier function, and therapeutic targets

Miyagaki

Sugaya

2015

Journal of Dermatological Science

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Section: Genetic Background Of Psoriasissupporting

confidence: 73%

Recent advances in atopic dermatitis and psoriasis: Genetic background, barrier function, and therapeutic targets

Miyagaki

Sugaya

2015

Journal of Dermatological Science

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“…These mice show a low grade of intestinal inflammation and Escherichia coli O157:H7‐challenged monolayers demonstrated diffuse fragmentation of ZO‐1 and claudin‐1 staining; pretreatment of basolateral compartment with vitamin D (10 −7 mol/L) for 16 h before infection attenuated the observed changes in tight‐junction integrity . Another study has demonstrated that vitamin D deficiency may predispose to adherent‐invasive E. coli (AIEC) colonization and infection; in vitro incubation of Caco‐2‐bbe cells with vitamin D is able to mitigate the deleterious effects of AIEC on the intestinal mucosa, by maintaining intestinal epithelial barrier homeostasis and preserving tight‐junction architecture . This study highlights the association between vitamin D status, dysbiosis and CD.…”

Section: Barrier Organsmentioning

confidence: 70%

“…Similarly to IBD in psoriasis, vitamin D is involved in the maintenance of cutaneous barrier homeostasis. Several studies have identified an association between VDR polymorphisms and psoriasis susceptibility . We have analyzed the polymorphisms of VDR gene and psoriasis susceptibility and we have found that in our population the A‐1012G promoter polymorphism of the VDR gene is associated with psoriasis risk and the mRNA of VDR in this polymorphism is lower expressed, favoring the conditions that may alter cutaneous barrier and the development of psoriatic lesions …”

Section: Barrier Organsmentioning

confidence: 70%

Psoriasis, vitamin D and the importance of the cutaneous barrier's integrity: An update

Mattozzi¹,

Paolino²,

Richetta³

et al. 2016

The Journal of Dermatology

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Psoriasis is a common, inflammatory, chronic, relapsing skin disease. Despite several hypotheses having been postulated to explain the pathogenesis of this disorder, nowadays it is considered as a T-cell-mediated disease; in this context an important role is played by vitamin D. The role of this micronutrient is important for many reasons: it is able to modulate the immune system; it is implicated in keratinocyte turnover; and it is involved in the integrity of the cutaneous barrier. In psoriasis, this molecule plays an important role due to its ability in the modulation of innate and adaptive immunity and by its antiproliferative and pro-differentiative effects on keratinocytes. Alteration of the metabolism of vitamin D may alter the cutaneous barrier integrity and favor an infective and inflammatory condition. The importance of vitamin D in the pathogenesis of psoriasis is not a mere mental exercise but may open further perspectives in the treatment of this disorder just preventing alterations of immune homeostasis, modulating the proliferation of keratinocyte, regulating the microbial flora and the response of the host to infective diseases.

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“…Richetta et al [89] showed that among 5 common VDR polymorphisms (A-1012G, FokI, BsmI, ApaI, and TaqI), the A-1021G polymorphism is associated with the risk of psoriasis in an Italian population. In another study, ApaI and a specific haplotype of 5 VDR polymorphisms were associated with the risk of psoriasis in a Chinese population [90]. In contrast, studies in Croatian and Egyptian populations did not find any role of VDR polymorphisms in psoriasis [91,92,93].…”

Section: Role Of Vitamin D In Certain Inflammatory Skin Diseasesmentioning

confidence: 99%

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Umar

Sastry

Ali

et al. 2018

Skin Pharmacol Physiol

147

135

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Background: Vitamin D is a secosteroid, which was initially known for its skeletal role; however, in recent years, its functions in different organs have been increasingly recognized. In this review, we will provide an overview of vitamin D functions in the skin physiology with specific focus on its role in certain inflammatory skin conditions such as psoriasis and atopic dermatitis. Methods: A comprehensive literature search was carried out in PubMed and Google Scholar databases using keywords like “vitamin D,” “skin,” “atopic dermatitis,” and “psoriasis.” Only articles published in English and related to the study topic were included in this review. Results: Vitamin D is integrally connected to the skin for its synthesis, metabolism, and activity. It regulates many physiological processes in the skin ranging from cellular proliferation, differentiation, and apoptosis to barrier maintenance and immune functions. Vitamin D deficiency is associated with the risk of psoriasis and atopic dermatitis, and several clinical/observational studies have suggested the beneficial effect of vitamin D in the therapy of these 2 inflammatory skin disorders. Conclusions: Vitamin D exerts a pleiotropic effect in the skin and could be an important therapeutic option for psoriasis and atopic dermatitis.

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The association of polymorphisms of the vitamin D receptor gene with psoriasis in the Han population of northeastern China

Cited by 25 publications

References 28 publications

Recent advances in atopic dermatitis and psoriasis: Genetic background, barrier function, and therapeutic targets

Recent advances in atopic dermatitis and psoriasis: Genetic background, barrier function, and therapeutic targets

Psoriasis, vitamin D and the importance of the cutaneous barrier's integrity: An update

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

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