The Association of Prepregnancy Body Mass Index with Pregnancy Outcomes in Chinese Women

Abstract

Our study was to evaluate the association between prepregnancy body mass index (BMI) and pregnancy outcomes. A total of 1546 women who attended prenatal care clinics and delivered at the Peking University International Hospital, Beijing, China, from October 2018 to April 2020 was included. This research explored gestational, perinatal, and postpartum outcomes, including gestational diabetes, anemia, preeclampsia, preterm premature rupture of membranes (PPROM), and postpartum hemorrhage. Participants were divided into underweight ( BMI < 18.5 kg / m 2 ), normal weight ( 18.5 kg / m 2 ≤ BMI ≤ 23.9 kg / m 2 ), overweight ( 24 kg / m 2 ≤ BMI ≤ 27.9 kg / m 2 ), and obese ( BMI ≥ 28 kg / m 2 ) groups. Logistic regression analysis was used to analyze the association between prepregnancy BMI and pregnancy outcomes, and odds ratio (OR) with 95% confidence interval (95% CI) was calculated. After adjusting potential confounders, the risk of PPROM was higher in the underweight group than the normal weight group ( OR = 1.864 , 95% CI: 1.269-2.737, P < 0.01 ). Prepregnancy obesity was associated with higher odds of gestational diabetes ( OR = 2.649 , 95% CI: 1.701-4.126, P < 0.001 ) and preeclampsia ( OR = 3.654 , 95% CI: 1.420-9.404, P < 0.01 ) than the normal weight group, whereas it correlated with the lower risk of anemia ( OR = 0.300 , 95% CI: 0.128-0.704, P < 0.01 ). Our findings may provide evidence for the importance of keeping normal weight for Chinese women when preparing for pregnancy.

Risk factors associated with adverse pregnancy outcomes and postpartum exacerbation in women with myasthenia gravis

“…Interestingly, higher pregestational BMI was identified as the only independent risk factor for maternal complications, with the cut‐off value of 22.03 kg/m 2 which is similar to the upper bound for appropriate BMI, 23, purposed by World Health Organization for the Asian population 21 . A recent study suggests that Chinese women should keep a normal weight when preparing for pregnancy to minimize the risk of adverse pregnancy outcomes 22 . However, corticosteroid treatment predisposes MG women to greater BMI.…”

“…21 A recent study suggests that Chinese women should keep a normal weight when preparing for pregnancy to minimize the risk of adverse pregnancy outcomes. 22 However, corticosteroid treatment predisposes MG women to greater BMI. In this way, controlling weight to the normal range becomes necessary for MG women who plan pregnancy.…”

Hemoglobin Levels, Anemia, and Their Associations with Body Mass Index among Pregnant Women in Hail Maternity Hospital, Saudi Arabia: A Cross-Sectional Study

“…In a population-based cross-sectional study that enrolled 5,679,782 women in China using pre-pregnancy BMI, the women with overweight and obesity were found to be at lower risk of anemia (AOR = 0.84 and AOR = 0.70, respectively) [ 34 ]. In another study that enrolled 1546 pregnant women in Peking University International Hospital, Beijing, China, pre-pregnancy obesity was associated with a lower risk of anemia (OR = 0.30) [ 35 ].…”

Effects of obesity indices/GDM on the pregnancy outcomes in Chinese women: A retrospective cohort study

“…Besides their impacts on the general population, these conditions also greatly affect pregnant women. Recent evidence suggested that nearly a quarter (23.9%) of the risk of any pregnancy complications could be attributed to maternal overweight or obesity, such as preterm premature rupture of membranes (PPROM), cesarean delivery, postpartum hemorrhage, and preeclampsia (5).…”