The association of serum <scp>FGF</scp>23 and non‐alcoholic fatty liver disease is independent of vitamin D in type 2 diabetes patients

He, Xingxing; Shen, Yun; Ma, Xiaojing; Ying, Lingwen; Peng, Jian; Pan, Xiaoping; Bao, Yuqian; Zhou, Jian

doi:10.1111/1440-1681.12933

Cited by 28 publications

(18 citation statements)

References 29 publications

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“…When comparing plasma FGF23 levels between these groups, we did not see any significant difference of FGF23 levels by ANOVA (Figure 3), suggesting that FGF23 elevations are a primary consequence of COPD. We did not screen for hepatic, endocrine or autoimmune disorders, which could also influence FGF23 levels [25,26].…”

Section: Resultsmentioning

confidence: 99%

Fibroblast Growth Factor 23 is Associated with a Frequent Exacerbator Phenotype in COPD: A Cross-Sectional Pilot Study

Gulati

Wells

Urdaneta

et al. 2019

IJMS

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Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory airway disease punctuated by exacerbations (AECOPD). Subjects with frequent AECOPD, defined by having at least two exacerbations per year, experience accelerated loss of lung function, deterioration in quality of life and increase in mortality. Fibroblast growth factor (FGF)23, a hormone associated with systemic inflammation and altered metabolism is elevated in COPD. However, associations between FGF23 and AECOPD are unknown. In this cross-sectional study, individuals with COPD were enrolled between June 2016 and December 2016. Plasma samples were analyzed for intact FGF23 levels. Logistic regression analyses were used to measure associations between clinical variables, FGF23, and the frequent exacerbator phenotype. Our results showed that FGF23 levels were higher in frequent exacerbators as compared to patients without frequent exacerbations. FGF23 was also independently associated with frequent exacerbations (OR 1.02; 95%CI 1.004–1.04; p = 0.017), after adjusting for age, lung function, smoking, and oxygen use. In summary, FGF23 was associated with the frequent exacerbator phenotype and correlated with number of exacerbations recorded retrospectively and prospectively. Further studies are needed to explore the role of FGF 23 as a possible biomarker for AECOPD to better understand the pathobiology of COPD and to help develop therapeutic targets.

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Section: Resultsmentioning

confidence: 99%

Fibroblast Growth Factor 23 is Associated with a Frequent Exacerbator Phenotype in COPD: A Cross-Sectional Pilot Study

Gulati

Wells

Urdaneta

et al. 2019

IJMS

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“…Interestingly, FGF23 is likely to promote hepatocyte proliferation [57] and does not seem to produce hepatic tissue injury since there is no increase in liver enzymes [57]. However, a recent study reported that FGF23 and reduced circulating calcifediol were independently associated with non-alcoholic fatty liver disease, perhaps because of its association with insulin resistance and diabetes [121].…”

Section: Effect On Different Organsmentioning

confidence: 99%

FGF23, Biomarker or Target?

Rodelo-Haad

Santamaría

Muñoz‐Castañeda

et al. 2019

Toxins

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Fibroblast growth factor 23 (FGF23) plays a key role in the complex network between the bones and other organs. Initially, it was thought that FGF23 exclusively regulated phosphate and vitamin D metabolism; however, recent research has demonstrated that an excess of FGF23 has other effects that may be detrimental in some cases. The understanding of the signaling pathways through which FGF23 acts in different organs is crucial to develop strategies aiming to prevent the negative effects associated with high FGF23 levels. FGF23 has been described to have effects on the heart, promoting left ventricular hypertrophy (LVH); the liver, leading to production of inflammatory cytokines; the bones, inhibiting mineralization; and the bone marrow, by reducing the production of erythropoietin (EPO). The identification of FGF23 receptors will play a remarkable role in future research since its selective blockade might reduce the adverse effects of FGF23. Patients with chronic kidney disease (CKD) have very high levels of FGF23 and may be the population suffering from the most adverse FGF23-related effects. The general population, as well as kidney transplant recipients, may also be affected by high FGF23. Whether the association between FGF23 and clinical events is causal or casual remains controversial. The hypothesis that FGF23 could be considered a therapeutic target is gaining relevance and may become a promising field of investigation in the future.

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“…Its prevalence in Iran is 47.85% in women and 34.75% in men (16,17). The higher prevalence of vitamin D deficiency is associated with a greater prevalence of obesity in the world (18,19). Recent epidemiological studies also show that low levels of serum vitamin D are associated with NAFLD (20).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Supplementation Increases the Aerobic Training Effects on Anthropometric Indices in Elderly Women with Non-Alcoholic Fatty Liver Disease and Vitamin D Deficiency

2019

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Background:Recent studies indicate that aerobic training may affect non-alcoholic fatty liver disease (NAFLD). Besides, vitamin D and NAFLD are known to have more than just an association. Objectives: This study aimed to examine the effects of vitamin D supplementation, combined with aerobic training, on anthropometric indices in elderly women with NAFLD and vitamin D deficiency. Methods: We randomly divided 40 elderly women with NAFLD and vitamin D deficiency into four groups: aerobic training + vitamin D supplementation (AT + Vit. D), aerobic training (AT), vitamin D supplementation (Vit. D), and control (C). The AT protocol consisted of 40 -60 minutes of aerobic training at 60% -75% of HRmax three times a week for eight weeks. The anthropometric indices included body weight (BW), body mass index (BMI), body fat percentage (BFP), and waist-hip ratio (WHR) measured at the start and after eight weeks of the study. Data were analyzed by paired t-test and ANOVA using SPSS version 21.0 software at a significance level of P < 0.05. Results: Anthropometric indices (BW, BMI, BFP, and WHR) significantly changed in all groups, with a significant increment in the control group and decrement in the AT + Vit. D, AT, and Vit. D groups. No significant differences were observed between the AT + Vit. D, AT, and Vit. D groups in the measured variables. Conclusions: Vitamin D supplementation combined with aerobic training improves the anthropometric indices in elderly women with NAFLD.

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The association of serum FGF23 and non‐alcoholic fatty liver disease is independent of vitamin D in type 2 diabetes patients

Cited by 28 publications

References 29 publications

Fibroblast Growth Factor 23 is Associated with a Frequent Exacerbator Phenotype in COPD: A Cross-Sectional Pilot Study

Fibroblast Growth Factor 23 is Associated with a Frequent Exacerbator Phenotype in COPD: A Cross-Sectional Pilot Study

FGF23, Biomarker or Target?

Vitamin D Supplementation Increases the Aerobic Training Effects on Anthropometric Indices in Elderly Women with Non-Alcoholic Fatty Liver Disease and Vitamin D Deficiency

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