The Association of Serum Zinc with Biomarkers Related to Longevity

Abstract

Objectives The objective of this study is to determine if there is an association between serum zinc and the possible biomarkers of longevity: ApoB, triglycerides, insulin, fasting glucose, Hba1c, and HS- CRP. Methods This cross-sectional study used data from 643 adult participants in a 2015–2016 NHANES study. Serum zinc concentrations were associated with ApoB, triglycerides, insulin, fasting glucose, Hba1c, and HSCRP using a multiple linear regression, adjusting for ethnicity/race, gender, waist circumference, BMI and age. Results The study consisted of 52% men and 48% woman. The mean age was 50 and the demographics were 17% Mexican American, 16% Other Hispanic, 35% White, 17% Black,12% Asian, and 3% Other Race. Serum zinc concentrations were inversely associated with HS- CRP (β = −.188, 95% CI −.003, −.001, P = .000) and positively associated with ApoB (β = .113, 95% CI .000, −.001, P = .010) in both men and women .When adjusting for age, gender, race/ethnicity, BMI and waist circumference, the model remained significant (adjusted R2 = .059, P = .000). Conclusions HS- CRP is associated with lower concentrations of serum zinc while ApoB is associated with higher concentrations of serum zinc. Further research should be conducted to understand the interaction between zinc and longevity. Funding Sources The study was funded in part by internal funds of Florida International University.