The association of TCF7L2 rs7903146 polymorphism with type 2 diabetes mellitus among Tatars of Bashkortostan

The multifactorial nature of type 2 diabetes mellitus (T2D) was confirmed by numerous researches. The first investigations devoted to molecular-genetic mechanisms of T2D were carried out on the basis of linkage disequilibrium (LD) studying and later the candidate genes of T2D have begun investigated. We have analyzed the literature data including the case-control studies in populations of Russia. There were revealed 33 genes and 65 polymorphic markers in the analyzed works. The analysis of association of T2D in the ethnic groups of Russian Federation was carried out on following genes: ABCC8, ADIPOQ, ADIPOR1, ADIPOR2, C2CD4A/C2CD4A, CDKAL1, CDKN2A/2B, CCL11, CCL20, CCL5, CYBA, FABP2, FTO, GCLC, GPX2, GSTP1, GSTT1, HHEX/IDE, IGF2BP2, IRS1, KCNJ11, KCNQ1, LPL, LRP5, MC4R, PPARG, SLC2A2, SLC30A8, SLC30A8, TCF7L2, TMEM18, WFS1, ZFAND6. The major of studies are replicative, i.e. repeating previous investigations of foreign authors, and were performed on Russian, Tatar and Yakut populations. At the same time not all the loci of genetic susceptibility have demonstrated the association with T2D in the population of Russia. In this work the systematic review of studies of molecular-genetic markers of T2D in the ethnic groups of Russian Federation was made for the first time.

show abstract

Association of polymorphic loci of susceptibility to diabetes mellitus type 2 in various ethnic groups of the Russian Federation

Авзалетдинова

Моругова

Шарипова

et al. 2021

Diabetes mellitus

Self Cite

View full text Add to dashboard Cite

show abstract

Association of single nucleotide variants of the TCF7L2, FABP2, FTO, DRD2, MC4R genes with morbid obesity in women

Ivanova,

Shabanova,

Zorina

et al. 2024

Obes. metabol.

View full text Add to dashboard Cite

BACKGROUND: Obesity is a widespread disease associated with serious complications. Obesity is a risk factor for many chronic diseases. The most common type of obesity is polygenic obesity, the pathogenesis of which involves external and internal factors, including genetic ones.AIM: Search and study of the association of variants of the nucleotide sequence rs9939609 of the FTO gene, rs7903146 of the TCF7L2 gene, rs1799883 of the FABP2 gene, rs1800497 of the DRD2 gene, rs17782313 of the MC4R gene with morbid obesity in women.MATERIALS AND METHODS: Study design is case-control study. The morbid obesity group and the control group were formed from the DNA bank of participants of the international project HAPIEE. Genotyping was performed by PCR-RFLP and real-time PCR (TaqMan probes, Applied Biosystems, USA). Statistical analysis was performed in SPSS software using Pearson’s chi-square test, Fisher’s exact two-tailed test with Yates’ correction for continuity. The significance level was used p<0.05.RESULTS: Morbid obesity group included 192 women (mean age 57.02± .16 years) with BMI over 40 kg/m2, control group included 450 women (mean age 55.44±7.41 years) with normal BMI (18.5-24.9 kg/m2). There were no statistically significant differences between the groups in the frequencies of genotypes and alleles rs7903146 of the TCF7L2 gene, rs1799883 of the FABP2 gene, rs1800497 of the DRD2 gene (p>0.05). In the group of morbid obesity, the proportion of carriers of the TT genotype rs9939609 of the FTO gene was statistically significantly lower, and the AT genotype was significantly higher than in the control group (OR=0.579, 95% CI 0.399-0.840, p=0.004; OR=1.408, 95% CI 1.003- 1.976, p=0.047, respectively). The heterozygous TC genotype rs17782313 of the MC4R gene is statistically significantly more common (OR=1.825, 95% CI 1.257-2.652, p=0.002), while the homozygous TT genotype is less common (OR=0.500, 95% CI 0.346-0.723, p<0.001) in group of morbid obesity compared with the control group.CONCLUSION: Heterozygous genotypes of the rs9939609 of the FTO gene (AT) and rs17782313 of the MC4R gene (TC) are risk genotypes; the homozygous genotype TT of the variants is protective for morbid obesity in women. Single nucleotide variants rs7903146 of the TCF7L2 gene, rs1799883 of the FABP2 gene, and rs1800497 of the DRD2 gene are not associated with morbid obesity in women.

show abstract

TCF7L2 gene polymorphism in populations of f ive Siberian ethnic groups

et al. 2022

View full text Add to dashboard Cite

Investigation of the frequencies of functionally signif icant gene variants in the context of medical biology and gene geography is a relevant issue for studying the genetic structure of human populations. The transition from a traditional to an urbanized lifestyle leads to a higher incidence of civilizational diseases associated with metabolic disorders, including type 2 diabetes mellitus. The goal of the present paper is to analyze the frequencies of functionally signif icant gene alleles in the metabolic prof iles of indigenous Siberian peoples to identify the gene pool resilience, evaluate the susceptibility of various ethnic groups to metabolic disorders under changing environmental conditions, and predict the epidemiological situation that may occur in the near future. The study was performed in the monoethnic samples of eastern and western Buryats, Teleuts, Dolgans, and two territorial groups of Yakuts. A real-time PCR was used to determine the frequencies of single nucleotide polymorphisms (SNPs) G103894T, rs12255372, and C53341T, rs7903146 in the TCF7L2 gene. The results obtained were compared to the frequencies identif ied for Russians from Eastern Siberia and the values available in the literature. The frequencies of the polymorphic variants studied in the samples from the indigenous Siberian peoples place them in between Caucasian and East Asian populations, following the geographic gradient of polymorphism distribution. A signif icantly lower occurrence of type 2 diabetes risk alleles TCF7L2 (103894T) and TCF7L2 (53341T) in the samples of indigenous Siberian peoples compared to Russians was observed, which agrees with their lower susceptibility to metabolic disorders compared to the newcomer Caucasian population. Taking into account urbanization, a reduced growth in type 2 diabetes incidence may be predicted in indigenous Siberian peoples, i. e. Buryats, Yakuts, Dolgans, and Teleuts, compared to the newcomer Caucasian population. A further study of population structure with respect to different metabolic prof ile genes is required to better understand the molecular genetic foundations of the adaptive potential of indigenous Siberian peoples.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The association of TCF7L2 rs7903146 polymorphism with type 2 diabetes mellitus among Tatars of Bashkortostan

Cited by 5 publications

References 21 publications

Association of polymorphic loci of susceptibility to diabetes mellitus type 2 in various ethnic groups of the Russian Federation

Association of polymorphic loci of susceptibility to diabetes mellitus type 2 in various ethnic groups of the Russian Federation

Association of single nucleotide variants of the TCF7L2, FABP2, FTO, DRD2, MC4R genes with morbid obesity in women

TCF7L2 gene polymorphism in populations of f ive Siberian ethnic groups

Contact Info

Product

Resources

About