The association of the IVS1-397T&gt;C estrogen receptor α polymorphism with the regulatory conditions in longstanding type 1 diabetic girls

Ryba, Monika; Malinowska, Ewa; Rybarczyk-Kapturska, Karolina; Brandt, Agnieszka; Myśliwiec, Małgorzata; Myśliwska, Jolanta

doi:10.1016/j.molimm.2011.09.004

Cited by 7 publications

(11 citation statements)

References 30 publications

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“…Similarly to our previous paper, regarding IVS1 −397TNC polymorphism (Ryba et al, 2011;Ryba-Stanisławowska et al, 2014), we found that T allele is associated with enhanced inflammatory response in DM1 boys. Our study revealed that boys possessing CC genotype had lower IL-6 and CRP serum level than their counterparts with CT and TT genotype.…”

Section: Discussionsupporting

confidence: 90%

“…The proinflammatory profile was displayed by greater production of TNF and IL-6 (Myśliwska et al, 2009). In another study conducted on DM1 adolescent girls, we have discovered that individuals carrying CC genotype were characterized by greater level of CD4+ Foxp3+ Tregs and simultaneous lowest TNF serum level in comparison to patients with CT and TT genotypes (Ryba et al, 2011). Moreover, elevated levels of analyzed proinflammatory factors (Th17 cells, cytokines) in DM1 girls carrying TT genotype promoted enhanced inflammatory response, which may cause diabetic-related microvascular complications (Ryba-Stanisławowska et al, 2014).…”

Section: Introductionmentioning

confidence: 85%

“…Associations between PvuII or XbaI polymorphisms and certain clinical conditions have been verified. These studies concern: risk of cardiovascular disease development (Herrington et al, 2002b;Myśliwska et al, 2009), osteoporosis (Albagha, McGuigan, Reid, & Ralstom, 2001;Becherini et al, 2009), cancer (Haiman et al, 1999;Weiderpass et al, 2000), increased blood pressure (Ellis, Infantino, & Harrap, 2004), spontaneous abortion (Anousha et al, 2013), multiple sclerosis (Niino, Kikuchi, Fukazawa, Yabe, & Tashiro, 2000), depression (Ryan & Ancelin, 2012), Alzheimer's disease (Boada et al, 2012), diabetes type 2 and obesity (Albagha et al, 2001), as well as type 1 diabetes (Ryba et al, 2011;Ryba-Stanisławowska, RybarczykKapturska, Brandt, Myśliwiec, & Myśliwska, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Grade of inflammation in boys with type 1 diabetes depends on the IVS1 −397T>C estrogen receptor α polymorphism

Słomiński

Myśliwska

Brandt

2015

Journal of Diabetes and its Complications

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

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Grade of inflammation in boys with type 1 diabetes depends on the IVS1 −397T>C estrogen receptor α polymorphism

Słomiński

Myśliwska

Brandt

2015

Journal of Diabetes and its Complications

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“…As it was mentioned, our previous studies showed the association between the −397T>C polymorphism of the estrogen receptor α gene and the quantitative characteristics of regulatory CD4 + Foxp3 + T cells in girls with type 1 diabetes [14]. Taking into account the fact that in type 1 diabetic patients the balance between regulatory T cells and their opposites, Th17, is disrupted [22, 26, 27], we have decided to check if and how the frequency of the latter cells depends on the −397T>C estrogen receptor α polymorphism.…”

Section: Resultsmentioning

confidence: 99%

“…The function of Tregs was shown by us and others to be compromised in type 1 diabetic subjects [10–13]. Furthermore we have found that the level of Tregs, as well as their ability to express Foxp3, may depend in part on estrogen receptor α polymorphism, which may simultaneously influence the inflammatory response in DM1 (diabetes mellitus type 1) females [14]. …”

Section: Introductionmentioning

confidence: 90%

IVS1 −397T>C Estrogen ReceptorαPolymorphism Is Associated with Low-Grade Systemic Inflammatory Response in Type 1 Diabetic Girls

Ryba-Stanisławowska

Rybarczyk-Kapturska

Brandt

et al. 2014

Mediators of Inflammation

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Purpose. The study aimed to investigate the influence of estrogen receptor α (ER-α) genotypes on inflammatory response and development of microvascular complications in girls with type 1 diabetes. Methods. 152 young regularly menstruating girls with diagnosed type 1 diabetes and 84 young, healthy menstruating girls were recruited. ER-α genotyping was carried out by PCR. Serum concentrations of 17β-estradiol, as well as IL-6, TNF-α, VEGF, and IL-10, were measured. CD4+Foxp3+ TH17 cells were isolated and analyzed by flow cytometry. Results. Type 1 diabetic girls carrying TT genotype were characterized by the lowest serum estradiol level and IL-10 and highest IL-6, TNF-α , and VEGF. The association between the level of certain cytokine and the genetic variant of estrogen receptor α polymorphism was analyzed. Frequencies of CD4+Foxp3+ TH17 cells were also enhanced in TT bearing girls with type 1 diabetes and correlated with the level of analyzed cytokines. In addition, the correlation between serum estradiol level and cytokine concentrations was observed. Conclusions. We propose that TT variant of estrogen receptor α polymorphism may be associated with enhanced inflammatory response, which in turn may lead to acceleration of diabetic retino- and nephropathy in girls with type 1 diabetes. This finding may help the physicians to predict the onset and progression of diabetic microvascular complications.

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Association of Lymphotoxin Alpha Polymorphism with Type 1 Diabetes in a Tunisian Population

et al. 2013

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We investigated the association of the lymphotoxin (LT)-α gene polymorphism +249A/G with type 1 diabetes. The distribution of genotypes of the LT-α +249A/G single nucleotide polymorphism (SNP) was assessed in 115 diabetic patients and 123 normoglycemic control subjects, using PCR-restriction fragment length polymorphism analysis. Among unselected patients, the SNP was significantly associated with increased risk of diabetes (χ2 = 8.44, p = 0.014) and was found to be more pronounced among female (χ2 = 8.37, p = 0.02) than male (χ2 = 6.11, p = 0.047) patients. A significant association was detected between LT-α +249A/G and increased risk of diabetes, in particular for young-onset patients (χ2 = 6.92, p = 0.031). Moreover, we reported significant differences in levels of HbA1c, triglycerides, alanine transaminase, and anti-glutamic acid decarboxylase-65 among alleles. Additional studies with extended patient age groups and different ethnicities are needed to confirm our findings.

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The association of the IVS1-397T>C estrogen receptor α polymorphism with the regulatory conditions in longstanding type 1 diabetic girls

Cited by 7 publications

References 30 publications

Grade of inflammation in boys with type 1 diabetes depends on the IVS1 −397T>C estrogen receptor α polymorphism

Grade of inflammation in boys with type 1 diabetes depends on the IVS1 −397T>C estrogen receptor α polymorphism

IVS1 −397T>C Estrogen ReceptorαPolymorphism Is Associated with Low-Grade Systemic Inflammatory Response in Type 1 Diabetic Girls

Association of Lymphotoxin Alpha Polymorphism with Type 1 Diabetes in a Tunisian Population

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