The association of triple-marker test results with adverse pregnancy outcomes in low-risk pregnancies with healthy newborns

Sayın, N. Cenk; Canda, Mehmet Tunç; Ahmet, Nefize; Arda, Sezer; Süt, Necdet; Varol, Füsun

doi:10.1007/s00404-007-0421-6

Cited by 32 publications

(25 citation statements)

References 27 publications

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“…17:20 Discrepancies between our findings and others include our null finding with respect to early preterm birth and increased nuchal translucency 17;22;33 and also the numerous reports of an association between preterm birth and second trimester abnormalities in hCG and uE3 – including patterns reported by some from our group. 21;26;34 While we suspect that the differences between our study and others with respect to NT may be due to our having too few pregnancies with increased NT in our study to be able to explore this relationship in detail, the difference between our study and other studies with respect to second trimester hCG and uE3 may be a result of our ability to consider both first and second trimester markers together.…”

Section: Commentcontrasting

confidence: 59%

Association of early-preterm birth with abnormal levels of routinely collected first- and second-trimester biomarkers

Jelliffe‐Pawlowski

Shaw

Currier

et al. 2013

American Journal of Obstetrics and Gynecology

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Objective To examine the relationship between typically measured prenatal screening biomarkers and early preterm birth in euploid pregnancies. Study Design Included were 345 early preterm cases (< 30 weeks) and 1,725 controls drawn from a population-based sample of California pregnancies that all had both first and second trimester screening results. Logistic regression analyses were used to compare patterns of biomarkers in cases and controls and to develop predictive models. Replicability of the biomarker-early preterm relationships revealed by the models was evaluated by examining the frequency and associated adjusted relative risks (RRsadj) for early preterm birth and for preterm birth in general (< 37 weeks) in pregnancies with identified abnormal markers compared to those without these markers in a subsequent independent California cohort of screened pregnancies (n = 76,588). Results The final model for early preterm birth included first trimester pregnancy-associated plasma protein A (PAPP-A) ≤ the 5th percentile, second trimester alpha-fetoprotein (AFP) ≥ the 95th percentile, and second trimester inhibin (INH) ≥ the 95th percentile (odds ratios 2.3 to 3.6). In general, pregnancies in the subsequent cohort with a biomarker pattern found to be associated with early preterm delivery in the first sample were at an increased risk for early preterm birth and preterm birth in general (< 37 weeks) (RRsadj 1.6 to 27.4). Pregnancies with two or more biomarker abnormalities were at particularly increased risk (RRsadj 3.6 to 27.4). Conclusion When considered across cohorts and in combination, abnormalities in routinely collected biomarkers reveal predictable risks for early preterm birth.

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Section: Commentcontrasting

confidence: 59%

Association of early-preterm birth with abnormal levels of routinely collected first- and second-trimester biomarkers

Jelliffe‐Pawlowski

Shaw

Currier

et al. 2013

American Journal of Obstetrics and Gynecology

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“…It was concluded that the triple test can be used not only for the detection of fetal chromosomal and neural tube defect abnormalities but also for the detection of high-risk pregnancies (16). Recently published data has shown that serum unconjugated estriol, AFP or hCG values in triple test results may be associated with development of oligohydramnios, gestational diabetes and macrosomia in women with healthy and normal appearing fetuses (17). Despite the increase in prematurity and low birth weight, unexplained raised levels of AFP were not associated with an increase in perinatal mortality (18).…”

Section: Discussionmentioning

confidence: 99%

Second trimester serum alpha-fetoprotein level is a significant positive predictor for intrauterine growth restriction in pregnant women with hyperemesis gravidarum

Özkaya¹,

Çakır²,

Çınar³

et al. 2011

J Turkish German Gynecol Assoc

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Second trimester serum alpha-fetoprotein level is a significant positive predictor for intrauterine growth restriction in pregnant women with hyperemesis gravidarum Objective: The aim of this study was to determine the association between three parameters of second trimester serum secreening and preterm labor and intrauterine growth restriction (IUGR) in patients with hyperemesis gravidarum (HG). Material and Methods:A prospective study on 429 pregnancies with HG was designed to determine the association between alpha-fetoprotein (AFP), unconjugated estriol (uE3), human chorionic gonadotropin (HCG) and pregnancy prognosis in terms of preterm labor, IUGR and birth weight.Results: In our study group the mean age of patients was 25.4±3.8years. Mean birth weight was 3180±555 g. Mean AFP, uE3, hCG levels in the study group were 1.44±0. Abstract ÖzetOriginal Investigation 220 Content

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“…Previous studies showed that maternal serum markers in the second trimester can predict adverse birth outcomes. 20,21 Whether the concentration of maternal AFP and β-HCG can predict inverse birth outcomes is inconsistent. Previous research reported that maternal AFP above 2 MoM increased the risk of PTB.…”

Section: Discussionmentioning

confidence: 99%

Associations between Maternal AFP and β-HCG and Preterm Birth

et al. 2019

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Objective Preterm birth (PTB) is a significant public health problem. We aimed to explore whether alpha fetal protein (AFP) or β-human gonadotropin (β-HCG) levels during pregnancy were associated with PTB in Chinese population. Study Design The clinical data collected Nanjing Medical University Affiliated Suzhou Hospital and Wuxi Maternity and Child Health Care Hospital between January 2006 and December 2011 were analyzed retrospectively. A total of 64,999 pregnant women were registered. In addition, 13,828 pregnant women were collected serum from the second trimester. The maternal serum AFP and β-HCG were measured by enzyme immunoassay. Results In our study, the rate of PTB is 6.23%. With each unit increase of maternal AFP concentration, the adjusted odds of PTB was increased by 69.3% (odds ratio = 1.693, 95% confidence interval: 1.434–1.999, p = 0.00). We set AFP concentrations as high, medium, and low levels. When comparing with low concentration of AFP, high concentration of AFP (≥1.179 M) was positively associated with PTB with adjustment for potential confounders (p < 0.05). Nevertheless, no statistically significant associations were observed between maternal β-HCG and PTB. Conclusion In this study, maternal AFP concentration was associated with increased risk of PTB.

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The association of triple-marker test results with adverse pregnancy outcomes in low-risk pregnancies with healthy newborns

Abstract: Serum estriol, AFP or HCG values in triple test results may be associated with development of oligohydramnios, gestational diabetes and macrosomia in women with healthy and normal appearing fetuses.

Cited by 32 publications

References 27 publications

Association of early-preterm birth with abnormal levels of routinely collected first- and second-trimester biomarkers

Association of early-preterm birth with abnormal levels of routinely collected first- and second-trimester biomarkers

Second trimester serum alpha-fetoprotein level is a significant positive predictor for intrauterine growth restriction in pregnant women with hyperemesis gravidarum

Associations between Maternal AFP and β-HCG and Preterm Birth

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