The Association of Unexplained Gastrointestinal Bleeding with Calcific Aortic Stenosis

King, Robert D.; Pluth, James R.; Giuliani, Emilio R.

doi:10.1016/s0003-4975(10)62112-1

Cited by 135 publications

(88 citation statements)

References 5 publications

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“…King et al [8] and several other authors [37,38] report that bleeding ceased in 95% of patients treated by valve replacement compared with 5% of those managed by laparotomy with or without bowel resection. Gastrointestinal angiodysplasias could disappear, as shown by endoscopy, after aortic valve replacement [36].…”

Section: Aortic Valve Replacementmentioning

confidence: 97%

“…Aortic valve replacement is recommended as the first line of treatment in this setting [4,6,8,16,38,50,60]. It improves the mucosal blood supply and corrects the haematological abnormality [60].…”

Section: Aortic Valve Replacementmentioning

confidence: 99%

“…Therefore, valve replacement with a biologic prosthesis has been recommended [8,16]. There are several reports where bleeding stopped after mechanical valve was replaced with a bioprosthetic valve [2,38].…”

Section: Tissue Valve Versus Mechanical Valvementioning

confidence: 99%

“…Chronic gastrointestinal bleeding associated with calcific aortic stenosis is a recognised association [2,3]. Despite several studies on this entity there are still many unanswered questions [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Intestinal angiodysplasia and aortic valve stenosis: let's not close the book on this association

Mishra¹,

Kováč²,

Caestecker³

et al. 2009

European Journal of Cardio-Thoracic Surgery

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SummaryThe association between gastrointestinal (GI) bleeding due to angiodysplasia of the large intestine and calcific aortic stenosis (AS) has been a matter of debate. Recent studies suggest that this association is related to subtle alterations in plasma coagulation factors. von Willebrand factor is the strongest possible link between aortic stenosis and bleeding associated with GI angiodysplasia. Physicians should be aware of this entity when dealing with elderly patients presenting either with GI bleeding or with AS. A high index of suspicion and appropriate diagnostic procedures followed by prompt treatment could be life saving. Several questions related to the pathogenesis and optimal management remain unanswered. Aortic valve replacement appears to offer the best hope of long-term resolution of the bleeding, and should be considered in most cases. The association between chronic gastrointestinal bleeding in elderly patients and aortic stenosis becomes more relevant with the advent of transcatheter aortic valve implantation which can be offered even to elderly patients with comorbidities which could make conventional surgery impossible. #

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Section: Aortic Valve Replacementmentioning

confidence: 97%

Section: Aortic Valve Replacementmentioning

confidence: 99%

Section: Tissue Valve Versus Mechanical Valvementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Intestinal angiodysplasia and aortic valve stenosis: let's not close the book on this association

Mishra¹,

Kováč²,

Caestecker³

et al. 2009

European Journal of Cardio-Thoracic Surgery

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“…In 1992 Olearchyk identified this association of symptoms as Heyde's syndrome [2]. It has been proven furthermore, that GI bleeding terminates after the aortic valve replacement surgery [3].…”

Section: Introductionmentioning

confidence: 99%

The association between aortic stenosis and intestinal angiodysplasia – the Heyde’s Syndrome (RCD code: VIII-1)

Dziedzic-Oleksy

Podolec

Sarnecka

et al. 2014

Journal of Rare Cardiovascular Diseases

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Heyde's syndrome is defined as a combination of gastrointestinal bleeding from a gastrointestinal angiodysplasia in patients with aortic stenosis. An acquired von Willebrand factor deficiency secondary to aortic stenosis is considered to be the major abnormality in Heyde's syndrome. Management of Heyde's syndrome requires cooperation of many different kinds of specialists: cardiologists, gastroenterologists, hematologists, general surgeons and cardiosurgeon. We present a care report of 62 years old female with no history of cardiovascular disorders referred to the Centre of Rare Cardiovascular Diseases in Kraków for cardiological evaluation of a heart murmur prior to a surgical procedure of a vascular malformation in colon. JRCD 2014; 1 (7): 17-20

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Increased Prevalence of Aortic Stenosis in Patients With Arteriovenous Malformations of the Gastrointestinal Tract in Heyde Syndrome

Batur¹,

Stewart²,

Isaacson³

2003

Arch Intern Med

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The Association of Unexplained Gastrointestinal Bleeding with Calcific Aortic Stenosis

Cited by 135 publications

References 5 publications

Intestinal angiodysplasia and aortic valve stenosis: let's not close the book on this association

Intestinal angiodysplasia and aortic valve stenosis: let's not close the book on this association

The association between aortic stenosis and intestinal angiodysplasia – the Heyde’s Syndrome (RCD code: VIII-1)

Increased Prevalence of Aortic Stenosis in Patients With Arteriovenous Malformations of the Gastrointestinal Tract in Heyde Syndrome

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