The associations between quality of life and clinical symptoms in individuals with an at-risk mental state and first-episode psychosis

Ohmuro, Noriyuki; Matsumoto, Kazunori; Ishii, Yu; Katsura, Masahiro; Obara, Chika; Kikuchi, Tatsuo; Hamaie, Yumiko; Ito, Fumiaki; Matsuoka, Hiroo

doi:10.1016/j.psychres.2017.04.031

Cited by 14 publications

(15 citation statements)

References 43 publications

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“…This might partly be attributable to the fact that cognitive impairment is frequently observed in patients with depressive and anxiety disorders (Castaneda, Tuulio-Henriksson, Marttunen, Suvisaari, & Lonnqvist, 2008;Lee, Hermens, Porter, & Redoblado-Hodge, 2012). Our results that ARMS individuals with comorbid diagnosis (primarily depressive and anxiety disorders) displayed significantly poorer subjective QoL (both mental and physical health domains) than those without comorbid diagnosis accord with most previous research which observed that subjective QoL was negatively correlated with mood symptoms, particularly depression, in ARMS samples (Ruhrmann et al, 2008;Domínguez-Martínez, Kwapil, & Barrantes-Vidal, 2015;Ohmuro et al, 2017). Contrary to a number of past studies which reported that psychiatric comorbidity was associated with poorer psychosocial functioning in ARMS individuals (Fusar-Poli et al, 2014;Lim et al, 2015;Rutigliano et al, 2016), we failed to find such significant relationships between comorbid disorder status and most of our functioning variables, with the exception of RFS extended social network subdomain.…”

Section: T a B L Esupporting

confidence: 85%

“…In fact, previous research demonstrated that comorbid diagnosis, primarily depressive and anxiety disorders, was associated with increased suicidality (Fusar-Poli et al, 2014) and tended to run a persistent or recurrent course over time in ARMS populations (Lin et al, 2014;Rutigliano et al, 2016). Some prior studies further suggested that ARMS individuals with psychiatric comorbidity might experience more severe psychopathology, greater functional impairment and poorer subjective quality of life (QoL) than those without comorbid disorder (Fusar-Poli et al, 2014;Kline et al, 2018;Lim et al, 2015;Ohmuro et al, 2017). Comparatively, there is a paucity of data regarding the relationship between psychiatric comorbidity and cognitive dysfunction in ARMS samples.…”

Section: Introductionmentioning

confidence: 99%

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Psychiatric comorbidity in individuals at‐risk for psychosis: Relationships with symptoms, cognition and psychosocial functioning

Chang

Chan

et al. 2020

Early Intervention Psych

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Aim: Psychiatric comorbidity frequently occurs with at-risk mental state (ARMS) for psychosis. Its relationships with psychopathology, cognition and functioning, however, remain to be further clarified. We aimed to examine prevalence and correlates of psychiatric comorbidity, and its associations with psychosocial functioning and subjective quality-of-life (QoL) in a representative sample of Chinese ARMS individuals.Methods: One hundred ten help-seeking participants aged 15 to 40 years with ARMS were recruited from a specialized early psychosis service in Hong Kong. ARMS status was verified by comprehensive assessment of at-risk mental state (CAARMS).Comorbid Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition nonpsychotic psychiatric disorders at baseline were ascertained using diagnostic interview and medical record review. Assessments encompassing symptom profiles, psychosocial functioning, subjective QoL and a brief cognitive battery were conducted.Results: Forty-nine (44.5%) ARMS participants were diagnosed as having comorbid non-psychotic psychiatric disorders at baseline, primarily depressive and anxiety disorders. Binary multiple logistic regression analysis revealed that female gender, more severe depressive symptoms, higher suicidality and poorer global cognitive functioning were independently associated with comorbid diagnosis status. ARMS participants with psychiatric comorbidity displayed significantly more limited extended social networks and poorer subjective QoL than those without psychiatric comorbidity. Conclusion:Comorbid disorders were frequently observed in Chinese ARMS individuals, and were linked to poorer cognition and higher suicide risk. Our findings

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Section: T a B L Esupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Psychiatric comorbidity in individuals at‐risk for psychosis: Relationships with symptoms, cognition and psychosocial functioning

Chang

Chan

et al. 2020

Early Intervention Psych

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“…The relationship between disturbed sleep and Quality of Life (QoL) is also an important line of enquiry; as the prevalence and impact of reduced QoL is well documented in ARMS groups (Fusar-Poli et al, 2015;Ohmuro et al, 2017;Ruhrmann et al, 2008). Furthermore, poor sleep has been implicated in the sustainment of decreased QoL in patients diagnosed with psychotic illness (Afonso et al, 2011;Hofstetter et al, 2005;Ritsner et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Sleep disturbances and the At Risk Mental State: A systematic review and meta-analysis

Clarke

Chisholm

Cappuccio

et al. 2021

Schizophrenia Research

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“…It has been shown that QoL is lower in UHR individuals than in the healthy population, and worse than in first-episode psychosis (Bechdolf et al, 2005;Domínguez-Martínez et al, 2015;Ruhrmann et al, 2008). Psychopathological symptoms have been the most commonly studied factors (Górna et al, 2008, Melle et al, 2005, and depressive symptoms have the greatest effect on QoL in both patients with first-episode psychosis and UHR individuals (Ohmuro et al, 2017;Ruhrmann et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Perceived stress mediates the relationship between social adaptation and quality of life in individuals at ultra high risk of psychosis

Ortega

Montalvo

Monseny

et al. 2019

Early Intervention Psych

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Aim Quality of life (QoL) and social functioning have emerged as good predictors of the outcome of psychotic disorders. Poor QoL and social functioning are usually present before the onset of the first episode of psychosis. Our study aimed to explore the relationship between social adaptation and QoL in young people at risk of psychosis (ultra‐high‐risk, UHR) and healthy controls (HCs), and to investigate potential mediating effects of stress measures (perceived stress, stressful life events). Methods The study included 55 UHR subjects and 40 HC. Social functioning was assessed with the Social Adaptation Self‐evaluation Scale (SASS). Stress measures included the assessment of stressful life events and perceived stress. We compared stress and QoL measures between UHR and HC, and also compared UHR with low or normal social adaptation. A mediation analysis was performed to explore whether stress measures mediated the relationship between social adaptation and QoL. Results UHR were less frequently employed and reported more stress, poorer QoL and lower social adaptation than HC. QoL and social adaptation were associated with stress measures. UHR with low social adaptation reported more perceived stress and less QoL than UHR with normal social adaptation and HC. Perceived stress mediated the relationship between social adaptation and QoL. Conclusions Social adaptation is less developed in UHR subjects than in healthy subjects and has a negative impact on quality of life. This association is mediated by perceived stress.

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The associations between quality of life and clinical symptoms in individuals with an at-risk mental state and first-episode psychosis

Cited by 14 publications

References 43 publications

Psychiatric comorbidity in individuals at‐risk for psychosis: Relationships with symptoms, cognition and psychosocial functioning

Psychiatric comorbidity in individuals at‐risk for psychosis: Relationships with symptoms, cognition and psychosocial functioning

Sleep disturbances and the At Risk Mental State: A systematic review and meta-analysis

Perceived stress mediates the relationship between social adaptation and quality of life in individuals at ultra high risk of psychosis

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