The associations between thermal variety and health: Implications for space heating energy use

Kennard, Harry; Huebner, Gesche M.; Shipworth, David; Oreszczyn, Tadj

doi:10.1371/journal.pone.0236116

Cited by 6 publications

(8 citation statements)

References 25 publications

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“…The wrist actigraph device housed a temperature sensor near the skin. Though its primary purpose was related to accelerometer calibration 17 , we found that the peripheral skin temperature signal (Figure S1) was strong enough to produce a phenotype characteristic of a biological origin. This wrist temperature signal was clearly discernable despite it being modulated ("masked") by sleep, ambient temperature conditions, food intake and other confounders.…”

Section: Resultsmentioning

confidence: 99%

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Diurnal rhythmicity of wearable device-measured wrist temperature predicts future disease incidence in the UK Biobank

Skarke

Brooks

Lahens

et al. 2023

Preprint

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Many chronic disease symptomatologies involve desynchronized sleep-wake cycles, indicative of disrupted biorhythms. This can be interrogated using body temperature rhythms, which are well-established biomarkers for circadian clock function. Here, we investigated the association of wrist temperature amplitudes with a future onset of disease in the UK Biobank one year after actigraphy. Among 425 disease conditions (range n = 200-6,728) compared to controls (range n = 62,107 − 91,134), a total of 73 (36.5%) disease phenotypes were significantly associated with decreased amplitudes of wrist temperature (Benjamini-Hochberg FDR q < 0.05) and 26 (13%) PheCODEs passed a more stringent significance level (Bonferroni-correction α < 0.05). Here, for example, a two-standard deviation (1.8° Celsius) lower wrist temperature amplitude corresponded to hazard ratios of 1.91 (1.58–2.31 95% CI) for NAFLD, 1.69 (1.53–1.88) for type 2 diabetes, 1.25 (1.14–1.37) for renal failure, 1.23 (1.17–1.3) for hypertension, and 1.22 (1.11–1.33) for pneumonia. A comprehensive phenome-wide atlas of the identified mappings has been made available at http://bioinf.itmat.upenn.edu/biorhythm_atlas/. These findings strongly suggest peripheral thermoregulation as a digital biomarker.

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Section: Resultsmentioning

confidence: 99%

“…To build on this and to explore the relationship between wrist temperature amplitudes and the future onset of diseases, we utilized temperature data collected through an embedded sensor in the actigraphy device that was used for the UKBB study, 17,18 .…”

Section: Introductionmentioning

confidence: 99%

Diurnal rhythmicity of wearable device-measured wrist temperature predicts future disease incidence in the UK Biobank

Skarke

Brooks

Lahens

et al. 2023

Preprint

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“…Third, lower air temperature in buildings at a university campus was associated with less tear film stability [ 46 ]. Higher thermal variety (linked to lower domestic demand temperatures) was associated with fewer morbidities related to cold mortality [ 75 ].…”

Section: Resultsmentioning

confidence: 99%

“… Bakke et al [ 46 ] 2008 Norway Lower air temperature Cross-sectional University buildings Tear film stability, nasal patency 4 university buildings 173 employees Lower air temperature in buildings at a university campus was associated with less tear film stability and more health problems. Kennard et al [ 75 ] 2020 United Kingdom Space heating energy use Cross-sectional Residential buildings Cold-mortality 77,762 households 77,762 adults Higher thermal variety (linked to lower domestic demand temperatures) was associated with less morbidities related to cold-mortality. …”

Section: Table A1mentioning

confidence: 99%

A Systematic Review of Associations between Energy Use, Fuel Poverty, Energy Efficiency Improvements and Health

Wang

Norbäck

2022

IJERPH

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Energy use in buildings can influence the indoor environment. Studies on green buildings, energy saving measures, energy use, fuel poverty, and ventilation have been reviewed, following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The database PubMed was searched for articles published up to 1 October 2020. In total, 68 relevant peer-reviewed epidemiological or exposure studies on radon, biological agents, and chemicals were included. The main aim was to assess current knowledge on how energy saving measures and energy use can influence health. The included studies concluded that buildings classified as green buildings can improve health. More efficient heating and increased thermal insulation can improve health in homes experiencing fuel poverty. However, energy-saving measures in airtight buildings and thermal insulation without installation of mechanical ventilation can impair health. Energy efficiency retrofits can increase indoor radon which can cause lung cancer. Installation of a mechanical ventilation systems can solve many of the negative effects linked to airtight buildings and energy efficiency retrofits. However, higher ventilation flow can increase the indoor exposure to outdoor air pollutants in areas with high levels of outdoor air pollution. Finally, future research needs concerning energy aspects of buildings and health were identified.

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“…Wrist temperature from the UKB study may reflect a combination of environmental ambient temperature and skin temperature and was collected originally to calibrate the accelerometer [20]. The traces, however, accurately captured the diurnal variability in distal skin temperature as previously reported.…”

Section: Wrist Temperatures Mark Circadian Rhythms and Disease Statementioning

confidence: 99%

Phenome-Wide Association Study of Actigraphy in the UK Biobank

Brooks

Lahens

Grant

et al. 2021

Preprint

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Wrist-worn accelerometer actigraphy devices present the opportunity for large-scale data collection from people during their daily lives. Using data from approximately 100,000 participants in the UK Biobank, actigraphy-derived measures of physical activity, sleep, and diurnal rhythms were associated in exploration and validation cohorts with a full phenome-wide set of diagnoses, biomarkers and metadata. Rhythmicity was captured by two independent models based on accelerometer and skin temperature harnessing behavioral (diurnal) and molecular (circadian) components. We found that robust rhythms significantly with biomarkers, survival, and phenotypes including diabetes, hypertension, mood disorders, and chronic airway obstruction; these associations were comparable to those with physical activity and sleep. Surprisingly, associations were mostly consistent between the sexes, while modulation by age was significant. More importantly, rhythms were found to be powerful predictors of future diseases: a two standard deviation difference in wrist temperature rhythms corresponded to increases in rate of diagnosis of 61% in diabetes, 38% in chronic airway obstruction, 27% in anxiety disorders, and 22% in hypertension. Our PheWAS of actigraphy data in the UK Biobank establishes that rhythmicity is fundamental to modeling disease trajectories, as are physical activity and sleep. Integration of long-term remote biosensing into patient care could thus afford an individualized approach to risk management.

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The associations between thermal variety and health: Implications for space heating energy use

Cited by 6 publications

References 25 publications

Diurnal rhythmicity of wearable device-measured wrist temperature predicts future disease incidence in the UK Biobank

Diurnal rhythmicity of wearable device-measured wrist temperature predicts future disease incidence in the UK Biobank

A Systematic Review of Associations between Energy Use, Fuel Poverty, Energy Efficiency Improvements and Health

Phenome-Wide Association Study of Actigraphy in the UK Biobank

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