2021
DOI: 10.1016/j.ekir.2020.12.025
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The Associations of Plasma Biomarkers of Inflammation With Histopathologic Lesions, Kidney Disease Progression, and Mortality—The Boston Kidney Biopsy Cohort Study

Abstract: Background Soluble tumor necrosis factor receptor (sTNFR)-1, sTNFR-2, YKL-40, monocyte chemoattractant protein (MCP)-1, and soluble urokinase plasminogen activator receptor (suPAR) have emerged as promising biomarkers of inflammation but have not been evaluated across diverse types of kidney diseases. Methods We measured these plasma biomarkers in 523 individuals enrolled into a prospective, observational cohort study of patients undergoing clinically indicated native k… Show more

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Cited by 27 publications
(27 citation statements)
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“…65 MCP-1 has also been reported to promote inflammation, kidney injury and fibrosis via macrophage accumulation in the kidney 66 and increased plasma levels of MCP-1 correlate with kidney disease progression. 67 Serum IL-8 levels positively correlated with markers of podocyte damage and with albuminuria in T2DM patients. 68,69 This study has several limitations.…”
Section: Discussionmentioning
confidence: 88%
“…65 MCP-1 has also been reported to promote inflammation, kidney injury and fibrosis via macrophage accumulation in the kidney 66 and increased plasma levels of MCP-1 correlate with kidney disease progression. 67 Serum IL-8 levels positively correlated with markers of podocyte damage and with albuminuria in T2DM patients. 68,69 This study has several limitations.…”
Section: Discussionmentioning
confidence: 88%
“…ET and MCP-1 are two types of immune factors closely related to kidney disease that are highly expressed in many kinds of nephropathy and can cause different degrees of damage to the affected kidney in a variety of ways. Therefore, ET and MCP-1 have important significance as clinical diagnostic indicators of kidney disease ( Ciarambino et al., 2021 ; Giraldi et al., 2020 ; Puthumana et al., 2021 ; Srivastava et al., 2021 ). In conclusion, inflammation caused by pesticides may be an important inducer of other secondary diseases, and ET and MCP-1 were the key factors by which pesticides interfered with the immune system in this study.…”
Section: Discussionmentioning
confidence: 99%
“…[35][36][37][38][39] Finally, other nonimaging-based biomarkers may also be helpful in understanding the types of injury occurring in the kidney. 40,41 Thus, it may be possible in the future to distinguish between the effects of each process on overall organ stiffness with a single multiparametric scanning session, with or without the use of adjunctive biomarker testing.…”
Section: Discussionmentioning
confidence: 99%