The atrophic dermatofibroma

Beer, Michaela; Eckert, F.; Schmoeckel, Christian

doi:10.1016/s0190-9622(08)80444-6

Cited by 40 publications

(52 citation statements)

References 8 publications

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“…Furthermore, metallothionein labelling, which correlated with active tissue reactions, decreased in atrophic dermatofibroma when sclerosis became prominent 2 . Therefore, we speculated that the cellularity decreased as the stage of atrophic dermatofibroma advanced, and that full‐grown atrophic dermatofibroma was the terminal stage of dermatofibroma, as proposed by Beer et al 3 …”

Section: Discussionmentioning

confidence: 60%

“…Sclerosis was most apparent at the centre of the lesion, and as one moved towards the centre, the histological findings changed from fibrous dermatofibroma through cellular dermatofibroma to sclerosis, and cellularity in the lesion decreased. In Pages’ 1 and Beers’ 3 series, the above histological stages were also observed. Ackerman 7 asserts that dermatofibroma results from some trauma, which causes three stages of inflammatory response: granulation tissue, granulomatous inflammation and, lastly, fibrosis.…”

Section: Discussionmentioning

confidence: 71%

“…Later, the entity was defined as a dermatofibroma with dermal atrophy of more than 50% of the locoregional dermis by Zelger et al 2 . To the best of our knowledge, only 48 cases have been reported in the English literature hitherto 1–6 . Atrophic dermatofibroma tends to occur on the upper back of middle‐aged women while conventional dermatofibroma tends to occur on the extremities of younger people.…”

Section: Discussionmentioning

confidence: 99%

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Atrophic dermatofibroma

Ohnishi

Sasaki

Nakai

et al. 2004

Acad Dermatol Venereol

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Atrophic dermatofibroma, a newly proposed entity in recent times, is thought to be a specific variant of dermatofibroma. We report a typical case of atrophic dermatofibroma on the thigh of a 69-year-old female. The lesion consisted clinically of a light brown, intracutaneous nodule with a central crateriform depression, and histologically of fibrohistiocytic components in the thinning dermis. On elastica van Gieson stain, loss of elastic fibres and dense accumulation of elastic fibres around medium-sized vessels were observed in the lesion.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

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Atrophic dermatofibroma

Ohnishi

Sasaki

Nakai

et al. 2004

Acad Dermatol Venereol

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“…In the three male cases reported by Zelger, 4 the location was buttock, back and thigh. We do not have any information about the location in the two patients reported by Beer 5 . Our patient is a distinctive case because he is a male and the lesion was located in the upper trunk.…”

Section: Discussionmentioning

confidence: 89%

“…Atrophic dermatofibroma represents approximately 2% of all dermatofibroma 4 . Previously, 51 cases had been reported 1–7 . Most occurred on the upper trunk of women.…”

Section: Discussionmentioning

confidence: 99%

Atrophic dermatofibroma accompanied by aneurysmatic characteristics

Curcó¹,

Pagerols²,

García³

et al. 2006

Acad Dermatol Venereol

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Atrophic Dermatofibroma: A Comprehensive Literature Review

Cohen

Erickson

Calame

2019

Dermatol Ther (Heidelb)

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Introduction An atrophic dermatofibroma is a benign fibrohistiocytic neoplasm. It typically presents as an asymptomatic patch with a depressed central area. Methods The PubMed database was used to search the following words: atrophic, dermatofibroma, elastic and fibers. The relevant papers and their references generated by the search were reviewed. Images of the clinical and pathological features of two patients with an atrophic dermatofibroma are presented. In addition, a comprehensive review of the characteristics of this unique dermatofibroma is provided. Results An atrophic dermatofibroma has been reported in 102 patients: 53 women, 11 men and 38 individuals whose gender was not provided. It typically appeared as an asymptomatic solitary patch with a central umbilication—most commonly on the shoulder or lower extremity or back—of women aged 48 years or older. Dermoscopy typically showed white scar-like patches; a patchy pigment network was also noted in some lesions. The pathology of an atrophic dermatofibroma has the same features that can be observed in a common fibrous dermatofibroma; there is acanthosis, basal layer hyperpigmentation, and induction of basal cell carcinoma-like features, hair follicle formation or sebaceous hyperplasia in the epidermis and a proliferation of spindle-shaped fibroblasts in the dermis. However, atrophic dermatofibromas also demonstrate depression of the central surface and thinning of the dermis; in many cases, the dermal atrophy is at least 50%. Elastic fibers are either decreased or absent. Similar to non-atrophic dermatofibromas, the immunoperoxidase profile of atrophic dermatofibromas is factor XIIIa-positive and cluster of differentiation 34 (CD34)-negative. The pathogenesis of atrophic dermatofibromas remains to be established. Conclusion An atrophic dermatofibroma is an uncommon benign variant of a dermatofibroma. The diagnosis can be suspected based on clinical features and dermatoscopic findings. A biopsy of the lesion will confirm the diagnosis. Periodic evaluation of the lesion site is a reasonable approach to the management of the residual tumor.

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The atrophic dermatofibroma

Cited by 40 publications

References 8 publications

Atrophic dermatofibroma

Atrophic dermatofibroma

Atrophic dermatofibroma accompanied by aneurysmatic characteristics

Atrophic Dermatofibroma: A Comprehensive Literature Review

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