The authenticity and quality of Rhodiola rosea products

Booker, Anthony; Jalil, Banaz; Frommenwiler, D; Reich, Eike; Lixiang, Zhai; Kulić, Žarko; Heinrich, Michael

doi:10.1016/j.phymed.2015.10.006

Cited by 73 publications

(49 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The NMR-based metabolomics is an useful tool in terms of quality control, since it allows obtaining structural information for a wide range of compounds in complex plant extracts or commercial products with a high analytical precision (Georgiev et al, 2015). This technique has been successfully applied in development of procedures for detection of marker phytochemicals found in a definite plant or commercial product, thus confirming their authenticity (Booker et al, 2016;Marchev et al, 2017a).…”

Section: Clinical Studiesmentioning

confidence: 99%

Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic

Vasileva

Marchev

Georgiev

2018

Food and Chemical Toxicology

View full text Add to dashboard Cite

Diverse groups of factors are leading to increased weight gain and obesity, such as certain genetic phenotypes, neuroendocrine disturbances, the administration of some drugs, behavioral, social and environmental factors. The progressively escalating rates of overweight and obesity worldwide have led to an introduction of a new term "globesity". Excessive accumulation of body fat and especially of visceral adipose tissue is the main predisposing factor for the development of metabolic syndrome and other obesity related co-morbidities. At the present moment only few pharmacotherapeuticals are used for long-term treatment of obesity acting on narrow target spectra, e.g. pancreatic and gastric lipase inhibition, acting as adrenomimetics or activating the satiety centers in hypothalamus. Plant-based medications that accelerate weight loss, proved to be safe, effective and widely available, would be a preferable alternative for anti-obesity treatments. As plant extracts are multi-component systems they could also act by more than one mechanism, including decreased lipid absorption, decreased energy intake, increased energy expenditure, decreased pre-adipocyte differentiation and proliferation, decreased lipogenesis and increased lipolysis. The current review gives a summary of the risk factors for obesity development and its characteristics consequences. Current treatment options, combining lifestyle changes and conventional treatment with commercial anti-obesity drugs have been described as well. Special emphasis on in vitro, in vivo and human studies, of potential medicinal plant extracts and phytochemicals, such as polyphenols, terpenoids, alkaloids, saponins, able to modulate the molecular pathways and gene/protein expressions related to obesity, have been highlighted.

show abstract

Section: Clinical Studiesmentioning

confidence: 99%

Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic

Vasileva

Marchev

Georgiev

2018

Food and Chemical Toxicology

View full text Add to dashboard Cite

show abstract

“…Faced with resource depletion and environment destruction, R. rosea and R. crenulata are becoming endangered, making them more economically valuable to collectors and middlemen, and also increasing the risk of adulteration and low quality. Poor quality and adulterated R. rosea products have been previously reported (Booker et al, 2015; Xin et al, 2015) and this paper investigates some aspects of the value chains that leads to the production of such products.…”

Section: Introductionmentioning

confidence: 96%

From Traditional Resource to Global Commodities:—A Comparison of Rhodiola Species Using NMR Spectroscopy—Metabolomics and HPTLC

et al. 2016

Self Cite

View full text Add to dashboard Cite

The fast developing international trade of products based on traditional knowledge and their value chains has become an important aspect of the ethnopharmacological debate. The structure and diversity of value chains and their impact on the phytochemical composition of herbal medicinal products, as well as the underlying government policies and regulations, have been overlooked in the debate about quality problems in transnational trade. Rhodiola species, including Rhodiola rosea L. and Rhodiola crenulata (Hook. f. & Thomson) H. Ohba, are used as traditional herbal medicines. Faced with resource depletion and environment destruction, R. rosea and R. crenulata are becoming endangered, making them more economically valuable to collectors and middlemen, and also increasing the risk of adulteration and low quality. Rhodiola products have been subject to adulteration and we recently assessed 39 commercial products for their composition and quality. However, the range of Rhodiola species potentially implicated has not been assessed. Also, the ability of selected analytical techniques in differentiating these species is not known yet. Using a strategy previously developed by our group, we compare the phytochemical differences among Rhodiola raw materials available on the market to provide a practical method for the identification of different Rhodiola species from Europe and Asia and the detection of potential adulterants. Nuclear magnetic resonance spectroscopy coupled with multivariate analysis software and high performance thin layer chromatography techniques were used to analyse the samples. Rosavin and rosarin were mainly present in R. rosea but also in Rosea sachalinensis Borris. 30% of the Rhodiola samples purchased from the Chinese market were adulterated by other Rhodiola spp. The utilization of a combined platform based on 1H-NMR and HPTLC methods resulted in an integrated analysis of different Rhodiola species. We identified adulteration at the earliest stage of the value chains, i.e., during collection as a key problem involving several species. This project also highlights the need to further study the links between producers and consumers in national and trans-national trade.

show abstract

“…The endangered status of R. rosea and the attractive market, which is rapidly growing led to more intensive research in domestication, cultivation, and even in biotechnological techniques such as in vitro cultures (Galambosi 2014). Collection from natural sites has several drawbacks including the possible adulteration with other species (Booker et al 2015) and the difficulty of standardizing the raw materials, since the collected roots and rhizomes are from plants of different ages (Kolodziej and Sugier 2013;Weglarz et al 2008). The cultivation of roseroot also does not ensure the standard quality of raw materials due to the high variability in the content of the active metabolites in plants of different origins which needs a long term monitoring and investigation on the content of active ingredients to be produced from different genotypes under different cultivation conditions (Linh et al 2000;Ganzera et al 2001;Peschel et al 2012;Altantsetseg et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Production of cinnamyl alcohol glycosides by biotransformation in roseroot callus cells

Mirmazloum

Kiss

Ladányi

et al. 2019

Plant Cell Tiss Organ Cult

View full text Add to dashboard Cite

Cinnamyl alcohol glycosides (CAGs) are the signature compounds of all roseroot preparations. The rapid growth in the market of roseroot-based products and the increasing demand for its raw material is causing serious threat for wild growing roseroot populations worldwide, which promotes the extensive studies to come up with alternative production resources. In this study the biotransformation of several precursors for the production of CAGs (rosin, rosavin, rosarin) in in vitro roseroot callus culture has been surveyed. Phenylalanine, trans-cinnamic acid, cinnamaldehyde and cinnamyl alcohol; the proposed precursors of CAGs, were added one by one to roseroot liquid callus cultures in 2 mM concentration. Samples were harvested and analysed by HPLC after 24, 48 and 96 h along with controls. All of the studied compounds, except phenylalanine, promoted the formation of CAGs. It was found that the closer the position of precursors to the final product in the biosynthesis pathway the more effective was the biotransformation into the final CAGs, both in terms of time and final product quantities. Addition of 2 mM trans-cinnamic acid and Cinnamyl alcohol resulted in 80-fold increase after 24 h and 130-fold increase after 96 h in callus samples, respectively. Rosin was the only compound which was released into the medium from the callus cells during the experiment and only in the cinnamyl alcohol-fed callus cells. These results revealed the potential of the precursors of the cinnamyl alcohol glycosides to be subject of biotransformation by roseroot callus cultures in order to produce the pharmaceutically important compounds. Key message Biotransformation of precursors in Rhodiola rosea callus culture has proved to be a feasible approach to sustainably enhance the content of active constituents in vitro. Keywords Cinnamyl alcohol glycosides • Precursor feeding • Cinnamyl alcohol • Rosavin • Rosarian • Rosin Abbreviations 2iP N 6-(2-Isopentenyl) adenosine BAP 6-BenzylAminoPurine CAGs Cinnamyl alcohol glycosides IAA Indole-3-Acetic Acid NAA α-NaphthaleneAcetic Acid PAL Phenylalanine ammonia lyase Phe Phenylalanine TCA trans-cinnamic acid Communicated by Konstantin V. Kiselev.

show abstract

The authenticity and quality of Rhodiola rosea products

Cited by 73 publications

References 10 publications

Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic

Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic

From Traditional Resource to Global Commodities:—A Comparison of Rhodiola Species Using NMR Spectroscopy—Metabolomics and HPTLC

Production of cinnamyl alcohol glycosides by biotransformation in roseroot callus cells

Contact Info

Product

Resources

About