The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member with neurite outgrowth-promoting activity

Furley, Andrew J.; Morton, Susan; Manalo, Dominador J.; Καραγωγεωσ, Δομνα; Dodd, Jane; Jessell, Thomas M.

doi:10.1016/0092-8674(90)90223-2

Cited by 563 publications

(401 citation statements)

References 57 publications

Supporting

Mentioning

377

Contrasting

Unclassified

Order By: Relevance

“…7A,B). To confirm this phenotype, we used two earlier markers of the Mauthner neurons: the antineurofilament antibody 3A10, which stains strongly Mauthner neurons at 30 hpf (Furley et al, 1990) (Fig. 7D), and val, which is expressed in Mauthner neurons at 20 hpf in addition to r5, r6 and associated neural crest cells (Fig.…”

Section: Knocking Down Iro7 Results In a Loss Of Primary Neurons In Tmentioning

confidence: 99%

The zebrafish Iroquois geneiro7positions the r4/r5 boundary and controls neurogenesis in the rostral hindbrain

et al. 2004

View full text Add to dashboard Cite

Early brain regionalisation involves the activation of genes coding for transcription factors in distinct domains of the neural plate. The limits of these domains often prefigure morphological boundaries. In the hindbrain,anteroposterior patterning depends on a segmentation process that leads to the formation of seven bulges called rhombomeres (r). The molecular cues involved in the early subdivision of the hindbrain and in rhombomere formation are not well understood. We show that iro7, a zebrafish gene coding for a transcription factor of the Iroquois family, is expressed at the end of gastrulation in the future midbrain and hindbrain territories up to the prospective r4/r5 boundary. This territory is strictly complementary to the expression domain of another homeobox gene, vhnf1, in the caudal neural plate. We demonstrate that Iro7 represses vhnf1 expression anterior to their common border and that, conversely, vHnf1 represses iro7 expression caudal to it. This suggests that the r4/r5 boundary is positioned by mutual repression between these two transcription factors. In addition, iro7 is involved in the specification of primary neurons in the rostral hindbrain. In particular, it is essential for the formation of the Mauthner neurons in r4. We propose that iro7 has a dual function in the hindbrain of the zebrafish embryo: it is required for the proper positioning of the prospective r4/r5 boundary and it promotes neurogenesis in the anterior hindbrain.

show abstract

Section: Knocking Down Iro7 Results In a Loss Of Primary Neurons In Tmentioning

confidence: 99%

The zebrafish Iroquois geneiro7positions the r4/r5 boundary and controls neurogenesis in the rostral hindbrain

et al. 2004

View full text Add to dashboard Cite

show abstract

“…This was one reason why L1, TAG-1, and SC-1 were selected for tests of CAM synthesis by axon-regenerating rat RGCs. Moreover, related proteins and direct homologs in various species have been demonstrated to be involved in axon elongation, recognition, fasciculation, and contact stabilization (i.e., TAG-1 in mouse: Furley et al, 1990; axonin-1 in chick: Ruegg et al, 1989;Stoeckli et al, 1991; L1 in mouse and rat: Bartsch et al, 1989;Mohajeri et al, 1996;; NgCAM in chick: Lemmon et al, 1989;Chang et al, 1987;Rathjen et al, 1987;Yamagata et al, 1995;E587 antigen in goldfish: Bastmeyer et al, 1995; SC-1/DM-GRASP in chick: Burns et al, 1991;Tanaka et al, 1991;Pollerberg and Mack, 1994;Yamagata et al, 1995;neurolin in goldfish: Bastmeyer et al, 1996). Moreover, CAMs activate signal transduction pathways which effect and modulate axon growth (Doherty and Walsh, 1994;Kunz et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Axon-Regenerating Retinal Ganglion Cells in Adult Rats Synthesize the Cell Adhesion Molecule L1 but Not TAG-1 or SC-1

Jung

Petrausch

Stuermer

1997

Molecular and Cellular Neuroscience

View full text Add to dashboard Cite

Retinal ganglion cells (RGCs) in rats regenerate axons in the presence of a PNS nerve graft. To determine if axonregenerating RGCs synthesize cell adhesion/recognition molecules which they possessed during development, retinae were subjected to in situ hybridization with antisense cRNA probes of L1, TAG-1, and SC-1 (and GAP-43 for comparison). L1 and TAG-1 (and GAP-43) proteins on axons were detected with antibodies. L1, TAG-1, and SC-1 (and Gap-43) mRNAs and L1 and TAG-1 (and Gap-43) proteins were expressed by RGCs in embryonic, postnatal, and adult rats. After optic nerve lesion (ONL), the surviving RGCs between 2 and 28 days after ONL continue to express L1. TAG-1 and SC-1 expression, however, is lost. In grafted rats, axon-regenerating RGCs express L1 (together with GAP-43) but neither TAG-1 nor SC-1. Thus, axonal regeneration in grafted rats occurs in the presence of L1 (and GAP-43) but in the absence of TAG-1 and SC-1.

show abstract

“…TAG-1/axonin-1 promotes growth cone elongation and contributes to fasciculation by homophilic (trans) interactions with the same molecules on opposed membranes and by heterophilic cis interactions with Ng-CAM/L1 in the same membrane (Furley et al, 1990;Kuhn et al, 1991;Rader et al, 1993;Felsenfeld et al, 1994). Furthermore, it interacts with NrCAM.…”

Section: Introductionmentioning

confidence: 99%

“…These CAMs often promote growth cone elongation and axon fasciculation, but it appears that they also act as sensors or receptors for guidance cues in regions where growth cones make pathway decisions Landmesser, 1995, 1998;Stoeckli et al, 1997;Ott et al, 1998;Leppert et al, 1999;Fitzli et al, 2000). Such has recently been discovered for the GPI-anchored IgSF CAM TAG-1/axonin-1, which consists of six Ig loops and four fibronectin type III (FN) domains and which, together with L1/Ng-CAM, NrCAM, and F3/F11 belongs to the Ig/FN III subfamily (Furley et al, 1990;Stoeckli et al, 1997;Fitzli et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Topographic Restriction of TAG-1 Expression in the Developing Retinotectal Pathway and Target Dependent Reexpression during Axon Regeneration

Lang

Warren

Klisa

et al. 2001

Molecular and Cellular Neuroscience

View full text Add to dashboard Cite

TAG-1, a glycosylphosphatidyl inositol (GPI)-anchoredprotein of the immunoglobulin (Ig) superfamily, exhibits an unusual spatiotemporal expression pattern in the fish visual pathway. Using in situ hybridization and new antibodies (Abs) against fish TAG-1 we show that TAG-1 mRNA and anti-TAG-1 staining is restricted to nasal retinal ganglion cells (RGCs) in 24-to 72-h-old zebrafish embryos and in the adult, continuously growing goldfish retina. Anti-TAG-1 Abs selectively label nasal RGC axons in the nerve, optic tract, and tectum. Axotomized RGCs reexpress TAG-1, which occurs as late as 12 days after optic nerve lesion, when regenerating RGC axons arrive in the tectum, suggesting TAG-1 reexpression is target contactdependent. Accordingly, TAG-1 reexpression ceases upon interruption of the regenerating projection by a second lesion. The topographic restriction of TAG-1 expression and its target dependency during regeneration suggests that TAG-1 might play a role in the retinotopic organization and restoration of the retinotectal pathway.

show abstract

The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member with neurite outgrowth-promoting activity

Cited by 563 publications

References 57 publications

The zebrafish Iroquois geneiro7positions the r4/r5 boundary and controls neurogenesis in the rostral hindbrain

The zebrafish Iroquois geneiro7positions the r4/r5 boundary and controls neurogenesis in the rostral hindbrain

Axon-Regenerating Retinal Ganglion Cells in Adult Rats Synthesize the Cell Adhesion Molecule L1 but Not TAG-1 or SC-1

Topographic Restriction of TAG-1 Expression in the Developing Retinotectal Pathway and Target Dependent Reexpression during Axon Regeneration

Contact Info

Product

Resources

About