The Baboon Model of Epilepsy: Current Applications in Biomedical Research

Szabó, C. Ákos; Leland, M. Michelle; Knape, Koyle D.; Williams, Jeff T.

doi:10.1007/978-0-387-75991-3_18

Cited by 3 publications

(1 citation statement)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The advantage of the baboon model is its similarity to human GGE (particularly JME) even in its response to antiepileptic medications ( Szabó et al, 2009 , Szabó et al, 2013 ). Even though we utilized ketamine for sedation, this imaging platform in the epileptic baboon is not affected by interactions with other antiepileptic medications, concerns over the subject's attentiveness while in the scanner, time restrictions which limit rs-fMRI scan length, and the reproducibility of the rs-fMRI data.…”

Section: Discussionmentioning

confidence: 99%

Resting-state functional connectivity changes due to acute and short-term valproic acid administration in the baboon model of GGE

Salinas

Szabó

2017

NeuroImage: Clinical

View full text Add to dashboard Cite

Resting-state functional connectivity (FC) is altered in baboons with genetic generalized epilepsy (GGE) compared to healthy controls (CTL). We compared FC changes between GGE and CTL groups after intravenous injection of valproic acid (VPA) and following one-week of orally administered VPA. Seven epileptic (2 females) and six CTL (3 females) baboons underwent resting-state fMRI (rs-fMRI) at 1) baseline, 2) after intravenous acute VPA administration (20 mg/kg), and 3) following seven-day oral, subacute VPA therapy (20–80 mg/kg/day). FC was evaluated using a data-driven approach, while regressing out the group-wise effects of age, gender and VPA levels. Sixteen networks were identified by independent component analysis (ICA). Each network mask was thresholded (z > 4.00; p < 0.001), and used to compare group-wise FC differences between baseline, intravenous and oral VPA treatment states between GGE and CTL groups. At baseline, FC was increased in most cortical networks of the GGE group but decreased in the thalamic network. After intravenous acute VPA, FC increased in the basal ganglia network and decreased in the parietal network of epileptic baboons to presumed nodes associated with the epileptic network. After oral VPA therapy, FC was decreased in GGE baboons only the orbitofrontal networks connections to the primary somatosensory cortices, reflecting a reversal from baseline comparisons. VPA therapy affects FC in the baboon model of GGE after a single intravenous dose—possibly by facilitating subcortical modulation of the epileptic network and suppressing seizure generation—and after short-term oral VPA treatment, reversing the abnormal baseline increases in FC in the orbitofrontal network. While there is a need to correlate these FC changes with simultaneous EEG recording and seizure outcomes, this study demonstrates the feasibility of evaluating rs-fMRI effects of antiepileptic medications even after short-term exposure.

show abstract

Section: Discussionmentioning

confidence: 99%

Resting-state functional connectivity changes due to acute and short-term valproic acid administration in the baboon model of GGE

Salinas

Szabó

2017

NeuroImage: Clinical

View full text Add to dashboard Cite

show abstract

Hair cortisol in captive corral-housed baboons

Lutz

Meyer

Novak

2021

General and Comparative Endocrinology

View full text Add to dashboard Cite

Classification of Current Experimental Models of Epilepsy

Rubio,

Romo-Parra,

López-Landa

et al. 2024

Brain Sciences

View full text Add to dashboard Cite

Introduction: This article provides an overview of several experimental models, including in vivo, genetics, chemical, knock-in, knock-out, electrical, in vitro, and optogenetics models, that have been employed to investigate epileptogenesis. The present review introduces a novel categorization of these models, taking into account the fact that the most recent classification that gained widespread acceptance was established by Fisher in 1989. A significant number of such models have become virtually outdated. Objective: This paper specifically examines the models that have contributed to the investigation of partial seizures, generalized seizures, and status epilepticus. Discussion: A description is provided of the primary features associated with the processes that produce and regulate the symptoms of various epileptogenesis models. Numerous experimental epilepsy models in animals have made substantial contributions to the investigation of particular brain regions that are capable of inducing seizures. Experimental models of epilepsy have also enabled the investigation of the therapeutic mechanisms of anti-epileptic medications. Typically, animals are selected for the development and study of experimental animal models of epilepsy based on the specific form of epilepsy being investigated. Conclusions: Currently, it is established that specific animal species can undergo epileptic seizures that resemble those described in humans. Nevertheless, it is crucial to acknowledge that a comprehensive assessment of all forms of human epilepsy has not been feasible. However, these experimental models, both those derived from channelopathies and others, have provided a limited comprehension of the fundamental mechanisms of this disease.

show abstract

The Baboon Model of Epilepsy: Current Applications in Biomedical Research

Cited by 3 publications

References 42 publications

Resting-state functional connectivity changes due to acute and short-term valproic acid administration in the baboon model of GGE

Resting-state functional connectivity changes due to acute and short-term valproic acid administration in the baboon model of GGE

Hair cortisol in captive corral-housed baboons

Classification of Current Experimental Models of Epilepsy

Contact Info

Product

Resources

About