The bacterial lipopeptide iturins induce <scp><i>V</i></scp><i>erticillium dahliae</i> cell death by affecting fungal signalling pathways and mediate plant defence responses involved in pathogen‐associated molecular pattern‐triggered immunity

Han, Qianqian; Wu, Fangfang; Wang, Xiaonan; Qian, Hong; Shi, Liang; Ren, Ang; Liu, Qinghai; Zhao, Mingwen; Tang, Canming

doi:10.1111/1462-2920.12538

Cited by 149 publications

(102 citation statements)

References 140 publications

(189 reference statements)

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“…B. amyloliquefaciens lipopeptide isolated from Japanese fermented food natto eliminated Rhizoctonia solani and Fusarium oxysporum (Murata et al 2013). Iturins compromised the viability of fungal plant pathogen Verticillium dahliae by upsetting the fungal signaling pathways and enhancing host plant immunity (Han et al 2014). Bacillus sp.…”

Section: Emerging Roles Beyond Medicine Bioremediationmentioning

confidence: 99%

Therapeutic cyclic lipopeptides mining from microbes: latest strides and hurdles

Patel

Ahmed

Eswari

2015

World J Microbiol Biotechnol

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Infectious diseases impose serious public health burdens and often have devastating consequences. The cyclic lipopeptides elaborated by bacteria Bacillus, Paenibacillus, Pseudomonas, Streptomyces, Serratia, Propionibacterium and fungus Fusarium are very crucial in restraining the pathogens. Composed of a peptide and a fatty acyl moiety these amphiphilic metabolites exhibit broad spectrum antimicrobial effects. Among the plethora of cyclic lipopeptides, only selective few have emerged as robust antibiotics. For their functional vigor, polymyxin, daptomycin, surfactin, iturin, fengysin, paenibacterin and pseudofactin have been integrated in mainstream healthcare. Daptomycin has been a significant part of antimicrobial arsenal since the past decade. As the magnitude of drug resistance rises in unprecedented manner, the urgency of prospecting novel cyclic lipopeptides is being perceived. Intense research has revealed the implication of these bioactive compounds stretching beyond antibacterial and antifungal. Anticancer, immunomodulatory, prosthetic parts disinfection and vaccine adjuvancy are some of the validated prospects. This review discusses the emerging applications, mechanisms governing the biological actions, role of genomics in refining structure and function, semi-synthetic analog discovery, novel strain isolation, setbacks etc. Though its beyond the scope of the current topic, for holistic purpose, the role of lipopeptides in bioremediation and crop biotechnology has been briefly outlined. This updated critique is expected to galvanize innovations and diversify therapeutic recruitment of microbial lipopeptides.

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Section: Emerging Roles Beyond Medicine Bioremediationmentioning

confidence: 99%

Therapeutic cyclic lipopeptides mining from microbes: latest strides and hurdles

Patel

Ahmed

Eswari

2015

World J Microbiol Biotechnol

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“…Furthermore, the mechanisms behind the observed biocontrol efficacy of different Bacillus strains have also been well described (4)(5)(6). Lipopeptides are able to induce systemic resistance in plants and to facilitate the multicellular behaviors of the producing strains, such as swarming motility, biofilm formation, and colony morphology (5)(6)(7).…”

mentioning

confidence: 99%

Unusual Biosynthesis and Structure of Locillomycins from Bacillus subtilis 916

Luo

Liu

Zhou

et al. 2015

Appl Environ Microbiol

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In the competition for nutrients, members of the Bacillus genus often produce a vast array of biologically active molecules that potentially inhibit the development of competing organisms. The Gram-positive bacterium Bacillus subtilis has an average of 4 to 5% of its genome devoted to antibiotic synthesis and is able to produce more than two dozen antibiotics with an amazing variety of structures (1). Many of these compounds, which have a peptide origin, are synthesized either ribosomally or nonribosomally. Among the nonribosomally generated amphipathic cyclic lipopeptides, surfactins, iturins, and fengycins have well-recognized potential applications in biotechnology and biopharmaceutical products due to their antagonistic activities and surfactant properties (2, 3). Furthermore, the mechanisms behind the observed biocontrol efficacy of different Bacillus strains have also been well described (4-6). Lipopeptides are able to induce systemic resistance in plants and to facilitate the multicellular behaviors of the producing strains, such as swarming motility, biofilm formation, and colony morphology (5-7).Surfactins, iturins, and fengycins are synthesized by nonribosomal peptide synthetases (NRPSs) which exhibit a distinct modular architecture (2, 8-10). A module is typically composed of three core domains, with each domain responsible for a certain biochemical reaction (11). Specifically, the amino acid adenylation domain (A domain) controls the entry of substrates into the peptide structure by recognizing and activating a specific amino acid. The thiolation domain (T domain), also referred to as the peptidyl carrier protein (PCP), contains an invariant serine residue which is essential for the binding of a 4=-phosphopantetheine cofactor. The N-terminal condensation domain (C domain) is required for the coupling of two consecutively bound amino acids (12, 13). These three domains constitute a minimal elongation module, the basic repetitive unit of a multimodular NRPS. Furthermore, modules can be supplemented with domains that catalyze modifications of the activated amino acid, such as N-methylation and epimerization. In some cases, when the first module of an NRPS complex lacks a C domain, the last module contains a termination thioesterase domain (TE domain) to release the end product (14). The order and specificity of the modules within the protein template determine the sequence of the product (for type A, linear NRPSs) (8, 11). Genetic and biochemical analyses have revealed that the modular arrangement of most lipopeptide synthetases is colinear with the amino acid sequences of lipopeptides (1, 2). This assembly line arrangement of the conserved catalytic modules and domains provides the means to construct hybrid NRPSs for use in the synthesis of new lipopeptide compounds (15-18). The prospect of creating numerous bioactive lipopeptides by engineering existing lipopeptide synthetases has stimulated the search for new NRPSs responsible for lipopeptide synthesis (19-24).To date, only two reported kinds of bios...

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“…Colonization of endophytic bacteria also elicits an oxidative burst in rice and the traditional Chinese medicine plant Atractylodes lancea (Alquéres et al, 2013;Han et al, 2015;Zhou et al, 2015). To detoxify the initial ROS produced by the plant, the endophytic bacteria may resort to ROS scavenging enzymes for help (Fig.3).…”

Section: Bacterial Endophytes Circumvent Host Defensementioning

confidence: 99%

“…The antimicrobial compounds produced by endophytic bacteria are promising in providing sufficient protection for plants against the invasion of phytopathogens. For instance, Bacillus amyloliquefaciens 41B-1 (an endophytic bacterium isolated from cotton) exhibited strong suppression of cotton wilt disease (caused by Verticillium dahlia) under glasshouse conditions (Han et al, 2015). A series of isoforms of iturins in B.…”

Section: Biocontrol By Endophytic Bacteriamentioning

confidence: 99%

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Effects of strategic tillage and plant hormone treatments on wheat-associated microbial communities

Liu¹

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The main aim of this thesis was to characterise microbial properties of microbiomes associated with wheat (Triticum aestivum) soils and wheat plants. In particular my objective was to better understand the effects on microbial communities following strategic tillage (ST) in wheat field soils and the activation of plant defence pathways in wheat plants. Throughout the thesis, multiple culture-independent methods, especially next-generation sequencing of 16S rRNA gene were used to profile soil microbial communities. Over half of the arable land in the northern grains region of Australia is managed using no-till (NT), a farming method which has improved crop yields and soil quality while reducing the input and labour costs. However, in recent years, concerns have arisen among farmers over the weed control in continuous NT systems. Strategic tillage has been touted as a potential solution, in particular for the severe weed infestations of long-term NT. Nevertheless, there is little information on the influence of ST on the microbial properties of Australian NT soils.In the present study, ST applications and soil sampling were performed in Moonie, Moree and Condamine during the fallow period in eastern Australia. These sites were chosen based on their long history of repeated wheat cultivation under NT farming practices and their different soil types.Overall, results show that in the Moonie trial on a Calcisol, one-time ST with either chisel or offset disc did not significantly influence the composition of soil bacterial communities when measured 13 months after tillage. However, relative to the NT, chisel tillage led to significant increases in microbial biomass carbon (MBC), abundances of Alphaproteobacteria, Bacteroidetes and Firmicutes as well as the utilisation of D+cellubiose and mannitol at 0-10 cm depth. In the Moree trial on a grey Vertosol, ST with different timing and implement demonstrated great potential in weed control and did not influence wheat yield and soil physicochemical and biological properties in the short-term. In the Condamine site on a Solonetz soil, one-or two-time chisel tillage did not influence soil MBC, total microbial enzymatic activity (MEA) or utilisation of C substrates.Likewise, ST did not change the soil microbial community structure and the abundance of genes encoding enzymes involved in key steps of C and N reactions. However, one-time chisel increased relative abundance of Acidobacteria RB41 and Acidobacteria iii1-15, and two-time chisel slightly increased the average C utilisation, at 10-20 cm depth. Overall, this thesis suggests that ST does not cause major impacts on soil properties of long-term NT and could be potentially used to address the long-term NT-associated issues without impacting overall soil properties.Recent reports demonstrate the importance of microbiomes associated with plants and their soil they are cultivated in. Beneficial microbes can significantly increase crop yields and provide biocontrol functions against plant pathogens, but prior to this stu...

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The bacterial lipopeptide iturins induce Verticillium dahliae cell death by affecting fungal signalling pathways and mediate plant defence responses involved in pathogen‐associated molecular pattern‐triggered immunity

Cited by 149 publications

References 140 publications

Therapeutic cyclic lipopeptides mining from microbes: latest strides and hurdles

Therapeutic cyclic lipopeptides mining from microbes: latest strides and hurdles

Unusual Biosynthesis and Structure of Locillomycins from Bacillus subtilis 916

Effects of strategic tillage and plant hormone treatments on wheat-associated microbial communities

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