The bacterial quorum sensing molecule, 2-heptyl-3-hydroxy-4-quinolone (PQS), inhibits signal transduction mechanisms in brain tissue and is behaviorally active in mice

Menna, Luisa Di; Busceti, Carla L.; Ginerete, Roxana Paula; D'Errico, Giovanna; Orlando, Rosamaria; Alborghetti, Marika; Bruno, Valeria; Battaglia, Giuseppe; Fornai, Francesco; Leoni, Livia; Rampioni, Giordano; Visca, Paolo; Monn, James A.; Nicoletti, Ferdinando

doi:10.1016/j.phrs.2021.105691

Cited by 2 publications

(2 citation statements)

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“…Apart from affecting bacterial functions and interactions, QS signalling molecules can also interact with host cell receptors, e.g. affecting mouse myoblasts [4] and the central nervous system signalling and behaviour in mice [5]. Despite differences in their molecular mechanisms and regulatory components, all QS systems regulate their target genes in a population-density dependent manner.…”

Section: Introductionmentioning

confidence: 99%

“…Those small molecules can either diffuse through the cell membrane and bind to LuxR-type cytoplasmic receptors, which mediate transcription regulation, or they are detected by transmembrane HKs in a process similar to that of Gram-positive bacteria [6]. Other molecules sensed by the QS receptors include pheromones, adrenaline and noradrenaline, sulphate and phosphate ions [10], fucose [11] and quinolones [5, 12].…”

Section: Introductionmentioning

confidence: 99%

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Evolution of two-component quorum sensing systems

Giannakara

Koumandou

2022

Access Microbiology

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Quorum sensing (QS) is a cell-to-cell communication system that enables bacteria to coordinate their gene expression depending on their population density, via the detection of small molecules called autoinducers. In this way bacteria can act collectively to initiate processes like bioluminescence, virulence and biofilm formation. Autoinducers are detected by receptors, some of which are part of two-component signal transduction systems (TCS), which comprise of a (usually membrane-bound) sensor histidine kinase (HK) and a cognate response regulator (RR). Different QS systems are used by different bacterial taxa, and their relative evolutionary relationships have not been extensively studied. To address this, we used the Kyoto Encyclopedia of Genes and Genomes (KEGG) database to identify all the QS HKs and RRs that are part of TCSs and examined their conservation across microbial taxa. We compared the combinations of the highly conserved domains in the different families of receptors and response regulators using the Simple Modular Architecture Research Tool (SMART) and KEGG databases, and we also carried out phylogenetic analyses for each family, and all families together. The distribution of the different QS systems across taxa, indicates flexibility in HK–RR pairing and highlights the need for further study of the most abundant systems. For both the QS receptors and the response regulators, our results indicate close evolutionary relationships between certain families, highlighting a common evolutionary history which can inform future applications, such as the design of novel inhibitors for pathogenic QS systems.

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Section: Introductionmentioning

confidence: 99%