Metal, metal oxide and polymeric nanoformulations for the inhibition of bacterial quorum sensing

Alavi, Mehran; Li, Li; Nokhodchi, Ali

doi:10.1016/j.drudis.2022.103392

Cited by 19 publications

(6 citation statements)

References 59 publications

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“…On particle size, morphology and composition the effect of metal based nanoparticles shapes such agglomeration importance role antimicrobial . [30]. Other reports revealed the effect of polymeric Nano formulations on bio lm cells attachment of Pseudomonas aeruginosa (PAO1) [31] Conclusions CuO NPs were successfully synthesized following an in, direct, eco-friendly, low cost, high-yield and green method, CuO NPs showed exceptional antimicrobial activity against several bacterial strains.…”

Section: Anti-bio Lm Activity Of Cuonps Sub-micmentioning

confidence: 99%

WITHDRAWN: Copper Nanoparticles on expression of LuxS of the genes in Pseudomonas aeruginosa strains anti-Biofilm formation

Ahmed¹,

Mohammed²

2023

Preprint

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The resistance to broad spectrum antimicrobials therapy such Pseudomonas aeruginosa, . Biofilms are major virulence factors to resist antibiotics; in this concern the need for providing new alternatives for antibiotics is becoming an urgent requirement,Now day therapies and applications based treatments felid nanoparticle. copper Oxide nanoparticles, were produced from MDR and strong biofilm producer P. aeruginosa isolate by biological method, against P. aeruginosa colonization of the biofilm and LuxSgene expression.This study was aimed to explore whether green synthesized copper nanoparticles (CuNPs) can function as an anti-biofilm agent of P. aeruginosa bacteria. The nanoparticles was synthesized from cell free extract of P. aeruginosa. Characterization of biosynthesized copper nanoparticles was carried out to determine the chemical and physical properties of the product usinging AFM, TEM ,XRD and UV visible spectrometry. The hexagonal structure was confirmed by XRD, size range was marked 13-19nm by TEM, was used to confirm the surface morphology. AFM analysis used to reveal the roughness and distribution of nanoparticles. UV–visible spectra of the synthesized nanoparticles recorded maximum peak at 300 nm. Copper nanoparticles showed remarkable biofilm inhibitory on multidrug resistant at (32 μg/ml) sub Minimum Inhibitory Concentration (MIC), CuNPs exhibited remarkable effect against P. aeruginosa .Strong biofilm producer strains were incubated with 1ml of sub MIC of CuNPs for 24 -48 hrs at 37C . The current study has proven that copper oxide nanoparticles possess the ability to act as anti-biofilm agents against P. aeruginosa. This was evidenced by their significant downregulation of LuxS gene expression, The results indicated a major down-regulation in LuxS expression after exposure to CuNPs, suggesting the antimicrobial agent against multidrug-resistant P. aeruginosa infections.

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Section: Anti-bio Lm Activity Of Cuonps Sub-micmentioning

confidence: 99%

WITHDRAWN: Copper Nanoparticles on expression of LuxS of the genes in Pseudomonas aeruginosa strains anti-Biofilm formation

Ahmed¹,

Mohammed²

2023

Preprint

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“…As mentioned in the standards used, we demonstrated the presence of silybin in S. marianum (control and laser treated). Mahmoudi Rad et al (2022) and Rad et al (2021) likewise recorded comparable outcomes ( Alavi et al, 2022 ). With the uplifting of the silybin compound of the laser radiation, S. marianum ethanolic extract had a smaller boosting effect on antibacterial activity against E. coli than that of S. typhi.…”

Section: Discussionmentioning

confidence: 86%

Potential antibacterial and antioxidant inhibitory activities of Silybum marianum mediated biosynthesised He-Ne laser

Aldayel

2023

Saudi Journal of Biological Sciences

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“…The antibacterial effects of many kinds of nanoparticles, such as metals [ 27 , 28 , 29 ], metal oxides [ 30 ], fullerene [ 31 , 32 , 33 ] and nanoparticles coated with different functional groups [ 34 , 35 , 36 ], have been studied. These nanoparticles (metal, metal oxides and fullerene) were shown to be effective bactericides by affecting bacterial signal transduction [ 37 , 38 ], disrupting bacterial cell membranes and causing leakage [ 39 , 40 , 41 ], or depleting intracellular ATP levels [ 42 , 43 , 44 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Different Nanoparticles on Microbes

Niu

Zhang

2023

Microorganisms

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Nanoparticles widely exist in nature and may be formed through inorganic or organic pathways, exhibiting unique physical and chemical properties different from those of bulk materials. However, little is known about the potential consequences of nanomaterials on microbes in natural environments. Herein, we investigated the interactions between microbes and nanoparticles by performing experiments on the inhibition effects of gold, ludox and laponite nanoparticles on Escherichia coli in liquid Luria–Bertani (LB) medium at different nanoparticle concentrations. These nanoparticles were shown to be effective bactericides. Scanning electron microscopy (SEM) images revealed the distinct aggregation of cells and nanoparticles. Transmission electron microscopy (TEM) images showed considerable cell membrane disruption due to nanoparticle accumulation on the cell surfaces, resulting in cell death. We hypothesized that this nanoparticle accumulation on the cell surfaces not only disrupted the cell membranes but also physically blocked the microbes from accessing nutrients. An iron-reducing bacterium, Shewanella putrefaciens, was tested for its ability to reduce the Fe (III) in solid ferrihydrite (HFO) or aqueous ferric citrate in the presence of laponite nanoparticles. It was found that the laponite nanoparticles inhibited the reduction of the Fe (III) in solid ferrihydrite. Moreover, direct contact between the cells and solid Fe (III) coated with the laponite nanoparticles was physically blocked, as confirmed by SEM images and particle size measurements. However, the laponite particles had an insignificant effect on the extent of aqueous Fe (III) bioreduction but slightly enhanced the rate of bioreduction of the Fe (III) in aqueous ferric citrate. The slightly increased rate of bioreduction by laponite nanoparticles may be due to the removal of inhibitory Fe (II) from the cell surface by its sorption onto the laponite nanoparticle surface. This result indicates that the scavenging of toxic heavy metals, such as Fe (II), by nanoparticles may be beneficial for microbes in the environment. On the other hand, microbial cells are also capable of detoxifying nanoparticles by coagulating nanoparticles with extracellular polymeric substances or by changing nanoparticle morphologies. Hence, the interactions between microbes and nanoparticles in natural environments should receive more attention.

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Metal, metal oxide and polymeric nanoformulations for the inhibition of bacterial quorum sensing

Cited by 19 publications

References 59 publications

WITHDRAWN: Copper Nanoparticles on expression of LuxS of the genes in Pseudomonas aeruginosa strains anti-Biofilm formation

WITHDRAWN: Copper Nanoparticles on expression of LuxS of the genes in Pseudomonas aeruginosa strains anti-Biofilm formation

Potential antibacterial and antioxidant inhibitory activities of Silybum marianum mediated biosynthesised He-Ne laser

Effects of Different Nanoparticles on Microbes

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