The Balance Between Normal and Tumor Tissues in Phototherapy of Tissues Harboring Cancer

Liu, Timon Cheng-Yi; Zhang, Jie; Li, Xing-Er

doi:10.1089/pho.2012.3355

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…In part, these differences may be also explained by variations in the cellular microenvironment, since these have been shown to affect cellular signal transduction pathways to PBM exposure [100]. The microenvironment of tumor cells varies among in vitro studies and differs significantly from that found in animal models.…”

Section: Discussion and Concluding Remarksmentioning

confidence: 99%

Low level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 1: mechanisms of action, dosimetric, and safety considerations

Zecha

Raber-Durlacher

Nair

et al. 2016

Support Care Cancer

211

140

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Purpose There is a large body of evidence supporting the efficacy of low level laser therapy (LLLT), more recently termed photobiomodulation (PBM), for the management of oral mucositis (OM) in patients undergoing radiotherapy for head and neck cancer (HNC). Recent advances in PBM technology, together with a better understanding of mechanisms involved, may expand the applications for PBM in the management of other complications associated with HNC treatment. This article (part 1) describes PBM mechanisms of action, dosimetry, and safety aspects and, in doing so, provides a basis for a companion paper (part 2) which describes the potential breadth of potential applications of PBM in the management of side-effects of (chemo)radiation therapy in patients being treated for HNC and proposes PBM parameters. Methods This study is a narrative non-systematic review. Results We review PBM mechanisms of action and dosimetric considerations. Virtually, all conditions modulated by PBM (e.g., ulceration, inflammation, lymphedema, pain, fibrosis, neurological and muscular injury) are thought to be involved in the pathogenesis of (chemo)radiation therapy-induced complications in patients treated for HNC. The impact of PBM on tumor behavior and tumor response to treatment has been insufficiently studied. In vitro studies assessing the effect of PBM on tumor cells report conflicting results, perhaps attributable to inconsistencies of PBM power and dose. Nonetheless, the biological bases for the broad clinical activities ascribed to PBM have also been noted to be similar to those activities and pathways associated with negative tumor behaviors and impeded response to treatment. While there are no anecdotal descriptions of poor tumor outcomes in patients treated with PBM, confirming its neutrality with respect to cancer responsiveness is a critical priority. Conclusion Based on its therapeutic effects, PBM may have utility in a broad range of oral, oropharyngeal, facial, and neck complications of HNC treatment. Although evidence suggests that PBM using LLLT is safe in HNC patients, more research is imperative and vigilance remains warranted to detect any potential adverse effects of PBM on cancer treatment outcomes and survival.

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Section: Discussion and Concluding Remarksmentioning

confidence: 99%

Low level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 1: mechanisms of action, dosimetric, and safety considerations

Zecha

Raber-Durlacher

Nair

et al. 2016

Support Care Cancer

211

140

View full text Add to dashboard Cite

show abstract

“…PBM therapy is one of the strategies used in this context . As tumor cells or premalignant cells could be irradiated unintentionally during the treatment of oral mucositis with PBM therapy in cases of head and neck cancer, evaluating the effects of laser irradiation parameters on tumor cells is a very important issue and has been the focus of previous reports . Since the development of osteolytic metastases is frequently associated with OSCC, the aim of this work was to evaluate the effects of different low‐level laser irradiations on the osteoclastogenic‐modulation properties of an OSCC cell line (SCC9), an issue that was not addressed before.…”

Section: Discussionmentioning

confidence: 99%

“…Photobiomodulation (PBM) therapy has been used as a therapeutic agent to modulate the inflammatory process in cases of oral mucositis induced by chemotherapy or radiotherapy . Understanding the effects that PBM therapy have on unintentionally irradiated tumor cells during such treatment has been the focus of many reports .…”

Section: Introductionmentioning

confidence: 99%

Photomodulation of the osteoclastogenic potential of oral squamous carcinoma cells

Schalch

Fernandes

Costa‐Rodrigues

et al. 2016

Journal of Biophotonics

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The treatment for oral cancer usually involves surgical excision followed by chemotherapy and/or radiotherapy. The combination of these therapies generally promotes a serious inflammation of the mucosa of the digestive tract, denominated mucositis, which compromises continuity of treatment. Photobiomodulation (PBM) therapy has been used successfully to reduce the oral mucositis, however there is still some controversy regarding the effects of this therapy on unintentionally irradiated tumor cells that may remain after cancer treatment. The aim of this study was to analyze the effect of PBM therapy (using parameters for mucositis) on the modulation of osteoclastogenic potential of a cell line derived from human lingual squamous cell carcinoma (SCC9). Previously irradiated SCC9 cells were co-cultured with human osteoclast precursors. Co-cultures performed with non-irradiated SCC9 cells served as control. After 7, 14 and 21 days the co-cultures were evaluated for the tartrate-resistant acid phosphatase (TRAP) activity, an osteoclastogenic marker. Additionally, the monocultures of SCC9 cells (non-irradiated and irradiated) were analyzed for cell viability/proliferation and for the expression of IL-11 and PTHrP. The irradiation of SCC9 cells with PBM with an energy density of 4 J/cm decreased the pro-osteoclastogenic potential of those cells. This may represent a potential useful side effect of PBM therapy. PBM (using recommended parameters for mucositis treatment) decreases the osteoclastogenic potential of oral squamous carcinoma cells.

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“…Distinct PBM parameters and doses have different effects on different types of tumor cells. Changes in the cellular microenvironment partially account for these differences, because it has been shown that these differences impact on signaling pathways exposed to PBM [56]. In vitro and in vivo models differ in the tumor microenvironment, suggesting that PBM may not always have negative effects on patients with cancer, despite its ability to increase tumor growth in vitro.…”

Section: Mechanism Of Action Of Pbm With Led 640 Nm On the Proliferat...mentioning

confidence: 99%

Mechanism of action of photobiomodulation with light‐emitting diode on the glutamine‐dependent CT26 cell

Hu,

Liu

2023

Journal of Biophotonics

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We investigated the mechanism of action of photobiomodulation(PBM) with led 640nm of glutamine dependent CT26 cells. Cells were exposed to 0.147–10.979 mW/cm2 of 640 ± 15 nm laser light for 15 min/day for 10 days. Cell proliferation and apoptosis were detected by MTT and Annexin V‐FITC assays. mRNA and protein levels of cell proliferation‐related genes were measured by RT‐PCR and western blotting, respectively. With Gln 7.94mM, on day 8 and 10, genes GLUT1, MEK1, ERK2, BCL2, E2F1, HO‐1, β‐ Catenin and Per2 was significantly upregulated (P<0.01) of glutamine addiction. In PBM therapy, compared with the non illuminated group, 2.17 mW/cm2 can significantly reduce cell apoptosis, the mRNA level of gene mTOR1 was significantly upregulated, and the protein level of raptor of GLUT1 and mTOR1,MEK1/2 and ERK1/2 were upregulated. Led 640nm inhibits cell apoptosis without increasing cell proliferation by regulating GLUT1, MEK/ERK, and PI3K/AKT/mTOR signals.This article is protected by copyright. All rights reserved.

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The Balance Between Normal and Tumor Tissues in Phototherapy of Tissues Harboring Cancer

Cited by 4 publications

References 17 publications

Low level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 1: mechanisms of action, dosimetric, and safety considerations

Low level laser therapy/photobiomodulation in the management of side effects of chemoradiation therapy in head and neck cancer: part 1: mechanisms of action, dosimetric, and safety considerations

Photomodulation of the osteoclastogenic potential of oral squamous carcinoma cells

Mechanism of action of photobiomodulation with light‐emitting diode on the glutamine‐dependent CT26 cell

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