The basic region/helix – loop – helix/leucine zipper domain of Myc proto-oncoproteins: Function and regulation

Lüscher, Bernhard; Larsson, Lars‐Gunnar

doi:10.1038/sj.onc.1202750

Cited by 185 publications

(135 citation statements)

References 96 publications

(99 reference statements)

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“…40 The binding of c-MYC to DNA relies on the CT region comprising basic (b) helix-loophelix (HLH) and LZ domains (bHLH-LZ) through heterodimerization with the MAX protein. 41 We first generated mutant FLAGtagged c-MYC proteins in which each of these specific domains was deleted (MBI, MBII, MBIII or CT) or mutant proteins at key positions for c-MYC stability (T58A and S62A) (Fig. 3A).…”

Section: Resultsmentioning

confidence: 99%

c-Myc protein is degraded in response to UV irradiation

Britton¹,

Salles²,

Calsou³

2008

Cell Cycle

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The c-MYC proto-oncogene encodes a transcription factor that is critical for cell growth and proliferation. It is one of the genes frequently altered in cancer cells in which it exhibits constitutive activity. The half-life of c-MYC is very short in quiescent cells due to ubiquitin-mediated proteolysis. We report here the rapid and dose-dependent decline of c-MYC protein level after UV-irradiation in various human and rodent cells. This decline is due to a proteasomal degradation of c-MYC protein and does not require the binding sites for the FBW7 and SKP2 ubiquitin ligases. Together, our data exclude a prominent role for the stress-responsive kinase PAK2, for the major phosphoinositide 3-kinase related protein kinases ATR, ATM, DNA-PK and mTOR and for ERK, JNK and p38 mitogen activated protein kinases in this UV-induced degradation process. We propose that c-MYC degradation is part of the global cell response to UV-damage, complementary to the accumulation and activation of the p53 transcription factor. By contributing to the replication arrest after infliction of lesions to the genome, the induced degradation of c-MYC may be part of the safeguard mechanisms maintaining genome stability.

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Section: Resultsmentioning

confidence: 99%

c-Myc protein is degraded in response to UV irradiation

Britton¹,

Salles²,

Calsou³

2008

Cell Cycle

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“…c-Myc protein dimerizes with the basic/helixloop-helix/leucine zipper (b/HLH/LZ) protein Max by its b/HLH/LZ motif and binds to the E-box (CACGTG) in the genome to regulate the transcription of adjacent genes (Luscher and Larsson, 1999). A co-factor, TRRAP, which is essential for c-Myc-mediated transformation and interacts with the MbI and MbII domains of the c-Myc, has been identified (McMahon et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Deregulated expression of a novel component of TFTC/STAGA histone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma: possible implication for the oncogenic potential of c-Myc

et al. 2007

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“…Transcriptional regulation of genes in a given tissue is controlled by a combination of mechanisms, for example changes in chromatin structure mediated by the association of histone acetylases and deacetylases (Wade 2001), binding of transcriptional regulators to an enhancer and/or a suppressor (Luscher and Larsson 1999), binding of transcription factors to a promoter region, and methylation of CpG islands in promoter sequences (Ballestar and Wolffe 2001). Although the precise mechanisms of cooperation among these elements are not well understood (Cha et al 2000), identification of common cis-elements that exist only in cartilage-specific genes should yield insight into the physiology of chondrocytes.…”

Section: Identification Of Separate Marker Genes For Hyaline Cartilagmentioning

confidence: 99%

Expression profiles of two types of human knee-joint cartilage

et al. 2003

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We have performed a comprehensive analysis of gene-expression profiles in human articular cartilage (hyaline cartilage) and meniscus (fibrocartilage) by means of a cDNA microarray consisting of 23,040 human genes. Comparing the profiles of the two types of cartilage with those of 29 other normal human tissues identified 24 genes that were specifically expressed in both cartilaginous tissues; these genes might be involved in maintaining phenotypes common to cartilage. We also compared the cartilage profiles with gene expression in human mesenchymal stem cells (hMSC), and detected 22 genes that were differentially expressed in cells representing the two cartilaginous lineages, 11 specific to each type, which could serve as markers for predicting the direction of chondrocyte differentiation. Our data should also provide useful information about regeneration of cartilage, especially in support of efforts to identify cartilage-specific molecules as potential agents for therapeutic approaches to joint repair.

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The basic region/helix – loop – helix/leucine zipper domain of Myc proto-oncoproteins: Function and regulation

Cited by 185 publications

References 96 publications

c-Myc protein is degraded in response to UV irradiation

c-Myc protein is degraded in response to UV irradiation

Deregulated expression of a novel component of TFTC/STAGA histone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma: possible implication for the oncogenic potential of c-Myc

Expression profiles of two types of human knee-joint cartilage

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