The Beginning of the Trend Change in Lung Cancer Mortality Trends in Spain, 1980–2018

Cayuela, L.; Lόpez-Campos, José Luís; Otero, Remedios; Portal, José Antonio Rodríguez; Rodríguez-Domínguez, Susana; Cayuela, Aurelio

doi:10.1016/j.arbr.2020.04.011

Cited by 7 publications

(8 citation statements)

References 32 publications

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“…Sex did not affect the short-term mortality, when relevant confounders were considered, although women had lower mortality risk than men. Consistent with our findings, other studies found that lung cancer mortality trends were higher among women than men, but mortality rates were still higher among Spanish men [38,39]. An increasing trend of tobacco use among women and the decreasing trend among men may contribute to this [38].…”

Section: Discussionsupporting

confidence: 91%

“…Consistent with our findings, other studies found that lung cancer mortality trends were higher among women than men, but mortality rates were still higher among Spanish men [38,39]. An increasing trend of tobacco use among women and the decreasing trend among men may contribute to this [38]. Granada had consistently higher overall short-term mortality than the wealthier Northern region of Girona, which confirms that social inequalities may play an important role in lung cancer mortality [40].…”

Section: Discussionsupporting

confidence: 90%

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The role of multimorbidity in short-term mortality of lung cancer patients in Spain: a population-based cohort study

et al. 2021

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Aim Chronic diseases often occur simultaneously and tend to be associated with adverse health outcomes, but limited research has been undertaken to understand their role in lung cancer mortality. Therefore, this study aims to describe the prevalence and patterns of having one (comorbidity) or ≥ 2 chronic diseases (multimorbidity) among lung cancer patients in Spain, and to examine the association between comorbidity or multimorbidity and short-term mortality risk at six months after cancer diagnosis. Methods In this population-based cohort study, data were drawn from two Spanish population-based cancer registries, Girona and Granada, and electronic health records. We identified 1259 adult lung cancer patients, diagnosed from 1st January 2011 to 31st December 2012. We identified the most common patterns of individual comorbidities and their pairwise correlations. We used a flexible parametric modelling approach to assess the overall short-term mortality risk 6 months after cancer diagnosis by levels of comorbidity after adjusting for age, sex, smoking status, province of residence, surgery, cancer stage, histology, and body mass index. Results We found high prevalence of comorbidity in lung cancer patients, especially among the elderly, men, those diagnosed with advanced-stage tumours, smokers, and obese patients. The most frequent comorbidities were chronic obstructive pulmonary disease (36.6%), diabetes (20.7%) and heart failure (16.8%). The strongest pairwise correlation was the combination of heart failure with renal disease (r = 0.20, p < 0.01), and heart failure with diabetes (r = 0.16, p < 0.01). Patients with either one or two or more comorbidities had 40% higher overall mortality risk than those without comorbidities (aHR for comorbidity: 1.4, 95%CI: 1.1–1.7; aHR for multimorbidity: 1.4, 95%CI: 1.1–1.8), when relevant confounding factors were considered. Conclusions The presence of comorbid diseases, rather than the number of comorbidities, was associated with increasing the risk of short-term lung cancer mortality in Spain. Comorbidity was a consistent and independent predictor of mortality among lung cancer patients, six months after diagnosis. The most common comorbid conditions were age-, obesity- and tobacco-related diseases. Our findings highlight the need to develop targeted preventive interventions and more personalised clinical guidelines to address the needs of lung cancer patients with one or more comorbidities in Spain.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

The role of multimorbidity in short-term mortality of lung cancer patients in Spain: a population-based cohort study

et al. 2021

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“…Notwithstanding, in all surgical cases, intra-operative systematic hilar and mediastinal lymphadenectomy (at least, ipsilateral paratracheal, subcarinal, and ipsilateral pulmonary ligament) was performed as previously recommended [1,2].…”

Section: Discussionmentioning

confidence: 99%

“…Nowadays, lung cancer (LC) continues to be a major cause of mortality worldwide [ 1 – 3 ]. Despite the progress in the diagnosis and treatment of LC that has been achieved in the last decades [ 2 ], the pathophysiology and underlying biology remain to be fully understood.…”

Section: Introductionmentioning

confidence: 99%

Gene expression profile of epithelial–mesenchymal transition in tumours of patients with nonsmall cell lung cancer: the influence of COPD

et al. 2022

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Epithelial-mesenchymal transition (EMT) is involved in the pathophysiology of lung cancer (LC) and chronic obstructive pulmonary disease (COPD), and the latter is an important risk factor for LC. We hypothesized that gene expression profile of EMT and signaling cascade may differ in LC patients with COPD from those with no respiratory diseases. In lung tumor specimens obtained through video-assisted thoracoscopic surgery (VATS) from LC (n=20, control group) and LC-COPD patients (n=30), gene expression (qRT-PCR) of EMT markers: SMAD3, SMAD4, ZEB2, TWIST1, SNAI1, ICAM1, VIM, CDH2, MMP1, and MMP9 were detected. In lung tumors of LC-COPD compared to LC patients, gene expression of SMAD3, SMAD4, ZEB2, and CDH2 significantly declined, while no significant differences were detected for the other analyzed markers. A significant correlation was found between packs-years (smoking burden) and SMAD3 gene expression among LC-COPD patients. LC-COPD patients exhibited mild-to-moderate airway obstruction and a significant reduction in diffusion capacity compared to LC patients. In lung tumor samples of patients with COPD, several markers of EMT expression, namely SMAD3, SMAD4, ZEB2, and CDH2 were differentially expressed suggesting that these markers are likely to play a role in the regulation of EMT in patients with this respiratory disease. Cigarette smoke did not seem to influence the expression of EMT markers in this study. These results have potential clinical implications in the management of patients with LC, particularly in those with underlying respiratory diseases.

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“…according to its pathogenesis and histological morphology ( Molina et al., 2008 ; Malhotra et al., 2016 ). As tobacco control increases, lung adenocarcinoma incidence is now higher than that of lung squamous cell carcinoma and has become the main cause of lung cancer-related death ( Siegel et al., 2021 ; Cayuela et al., 2021 ). However, lung cancer prognosis is still poor.…”

Section: Introductionmentioning

confidence: 99%

Signature identification of relapse-related overall survival of early lung adenocarcinoma after radical surgery

Han

Yue

Kong

et al. 2021

PeerJ

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Background The widespread use of low-dose chest CT screening has improved the detection of early lung adenocarcinoma. Radical surgery is the best treatment strategy for patients with early lung adenocarcinoma; however, some patients present with postoperative recurrence and poor prognosis. Through this study, we hope to establish a model that can identify patients that are prone to recurrence and have poor prognosis after surgery for early lung adenocarcinoma. Materials and Methods We screened prognostic and relapse-related genes using The Cancer Genome Atlas (TCGA) database and the GSE50081 dataset from the Gene Expression Omnibus (GEO) database. The GSE30219 dataset was used to further screen target genes and construct a risk prognosis signature. Time-dependent ROC analysis, calibration degree analysis, and DCA were used to evaluate the reliability of the model. We validated the TCGA dataset, GSE50081, and GSE30219 internally. External validation was conducted in the GSE31210 dataset. Results A novel four-gene signature (INPP5B, FOSL2, CDCA3, RASAL2) was established to predict relapse-related survival outcomes in patients with early lung adenocarcinoma after surgery. The discovery of these genes may reveal the molecular mechanism of recurrence and poor prognosis of early lung adenocarcinoma. In addition, ROC analysis, calibration analysis and DCA were used to verify the genetic signature internally and externally. Our results showed that our gene signature had a good predictive ability for recurrence and prognosis. Conclusions We established a four-gene signature and predictive model to predict the recurrence and corresponding survival rates in patients with early lung adenocarcinoma after surgery. These may be helpful for reforumulating post-operative consolidation treatment strategies.

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The Beginning of the Trend Change in Lung Cancer Mortality Trends in Spain, 1980–2018

Cited by 7 publications

References 32 publications

The role of multimorbidity in short-term mortality of lung cancer patients in Spain: a population-based cohort study

The role of multimorbidity in short-term mortality of lung cancer patients in Spain: a population-based cohort study

Gene expression profile of epithelial–mesenchymal transition in tumours of patients with nonsmall cell lung cancer: the influence of COPD

Signature identification of relapse-related overall survival of early lung adenocarcinoma after radical surgery

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