The behavioural and neurochemical profile of the putative dopamine D3 receptor agonist, (+)-PD 128907, in the rat

Bristow, Linda J.; Cook, G.P.; Gay, Juliette; Kulagowski, Janusz J.; Landon, Linda A.; Murray, Fraser; Saywell, K. L.; Young, Lisa; Hutson, Peter H.

doi:10.1016/0028-3908(96)00179-7

Cited by 49 publications

(41 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, the finding that PD 128907 only induces a modest antidepressant-like effect at the highest dose tested may suggest that this dose is beginning to stimulate D 2 receptors which are in turn mediating the antidepressant effect. However, the dose of PD 128907 that showed antidepressant-like activity in our study (0.7 mmol/kg ¼ 0.2 mg/kg; Figure 3) has been previously reported to be selective for stimulating D 3 receptors suggesting that this modest effect may reflect a modest ability of D 3 receptor activation to induce an antidepressant effect in FST (Bristow et al, 1996;Chaperon et al, 2003). Potential involvement of D 3 receptors might also be indicated by the data obtained in the antagonism study.…”

Section: Discussionsupporting

confidence: 56%

Antidepressant-Like Effect of D2/3 Receptor-, but not D4 Receptor-Activation in the Rat Forced Swim Test

Basso

Gallagher

Bratcher

et al. 2005

Neuropsychopharmacol

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 56%

Antidepressant-Like Effect of D2/3 Receptor-, but not D4 Receptor-Activation in the Rat Forced Swim Test

Basso

Gallagher

Bratcher

et al. 2005

Neuropsychopharmacol

View full text Add to dashboard Cite

“…Similarly, dopamine D 2 and D 3 receptors appear to exert an opposing control on the expression of neurotensin in the nucleus accumbens, possibly via contrasting modulation of c-fos expression (Das et al, 1997;Diaz et al, 1997). In accordance with these comments, low and high doses of 7-OH-DPAT and PD 128,907 may decrease and increase locomotion by activation of postsynaptic D 3 and D 2 receptors, respectively (Svensson et al, 1994;Bristow et al, 1996).…”

Section: Biphasic Induction Of C-fossupporting

confidence: 51%

“…This preparation is important in that, in comparison to transfected and immortalised nonneuronal cell lines, it permits an evaluation of actions mediated by native D 3 receptors in neuronal tissue. To establish a putative role of D 3 vs. D 2 receptors, we employed two prototypical and preferential D 3 receptor agonists, PD 128, 907 and (Ϯ)-7-OH-DPAT, together with the selective D 3 antagonist (ϩ)-S 14297 and its less active distomer (Ϫ)-S 17777 Millan et al, 1995;Pugsley et al, 1995;Lévesque, 1996;Bristow et al, 1996).…”

mentioning

confidence: 99%

Activation of dopamine D3 receptors induces c-fos expression in primary cultures of rat striatal neurons

et al. 2000

View full text Add to dashboard Cite

A modulation of the expression of immediate-early genes (IEGs) such as c-fos is likely involved in the long-term influence of dopaminergic ligands on the activity of basal ganglia neurons. The roles of individual dopamine receptor types in this regard remain unclear, and the present study employed primary cultures of rat striatal neurons to examine the potential modulation of c-fos expression by D(3) receptors. Neurons were treated with the preferential D(3) receptor agonists, (+/-)-7-OH-DPAT and PD 128,907, which showed, respectively, 16-fold and 56-fold selectivity for recombinant rat D(3) vs. D(2) receptors (K(i) values, rD(2)/rD(3) = 59.5/3.7 nM and 251/4.5 nM, respectively). At concentrations of 3 and 30 nM, respectively, (+/-)-7-OH-DPAT and PD 128,907 significantly increased the expression of c-fos mRNA. The action of (+/-)-7-OH-DPAT was expressed stereospecifically; its (+)-isomer (K(i) values, D(3)/D(2) = 1.6/56.7 elicited a 26% +/- 7.6% increase in c-fos expression whereas its (-)-isomer (K(i) values, D(3)/D(2) = 59/1,060 nM) was ineffective. Further, stimulation of c-fos mRNA expression by PD 128,907 (20 nM) was markedly and significantly (P < 0.05) attenuated (-91.8% +/- 5.3%) by 30 nM of the selective D(3) receptor antagonist, (+)-S 14297 (K(i) values, D(3)/D(2) = 11/401 nM). In contrast, the action of PD 128,907 was significantly less affected (-24.5% +/- 7.8%) by 30 nM of its less active distomer, (-)-S 17777 (K(i) values, D(3)/D(2) = 294/3,191 nM). An examination of the concentration-response relationship revealed that (+/-)-7-OH-DPAT and PD 128,907 both produced bell-shaped dose-response curves for c-fos induction. The sequential activation of D(2) receptors-which inhibit striatal c-fos expression (Simpson and Morris [1995] Neuroscience 68:97-106)-by higher concentrations of (+/-)-7-OH-DPAT and PD 128,907 is presumably involved in the inflexion at higher doses. In conclusion, the present data demonstrate that activation of D(3) receptors results in a selective induction of c-fos mRNA expression in cultured striatal neurons. These data show that neuronal D(3) receptors control the expression of IEGs and suggest that D(3) receptors may mediate long-term adapative changes in the activity of neurons in the basal ganglia.

show abstract

“…There are several interesting biological candidate genes with sequence diversity in the proximal PPI QTL. Drd3 is the most intriguing candidate gene on the basis of numerous reports of PPI alterations in response to dopamine agonists and antagonists in mice, rats, and humans Swerdlow et al 2001a;Ralph-Williams et al 2002, 2003 and pharmacological evidence for D3 receptor involvement in rat PPI (Caine et al 1995;Bristow et al 1996;Varty and Higgins 1998). Other strong biological candidate genes in the proximal QTL region include Lsamp, which mediates neuronal growth and axon targeting (Pimenta et al 1995), Gap43, which is involved in axonal outgrowth and regeneration (Benowitz and Routtenberg 1997), Zbtb20, which is implicated in hippocampal neurogenesis (Mitchelmore et al 2002), and Tagln3, which is selectively expressed in neuronal subpopulations (Ren et al 1994) and is implicated in actin filament assembly (Mori et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Two Quantitative Trait Loci for Prepulse Inhibition of Startle Identified on Mouse Chromosome 16 Using Chromosome Substitution Strains

et al. 2005

View full text Add to dashboard Cite

Prepulse inhibition (PPI) of acoustic startle is a genetically complex quantitative phenotype of considerable medical interest due to its impairment in psychiatric disorders such as schizophrenia. To identify quantitative trait loci (QTL) involved in mouse PPI, we studied mouse chromosome substitution strains (CSS) that each carry a homologous chromosome pair from the A/J inbred strain on a host C57BL/6J inbred strain background. We determined that the chromosome 16 substitution strain has elevated PPI compared to C57BL/6J (P ¼ 1.6 3 10 ÿ11

show abstract

The behavioural and neurochemical profile of the putative dopamine D3 receptor agonist, (+)-PD 128907, in the rat

Cited by 49 publications

References 39 publications

Antidepressant-Like Effect of D2/3 Receptor-, but not D4 Receptor-Activation in the Rat Forced Swim Test

Antidepressant-Like Effect of D2/3 Receptor-, but not D4 Receptor-Activation in the Rat Forced Swim Test

Activation of dopamine D3 receptors induces c-fos expression in primary cultures of rat striatal neurons

Two Quantitative Trait Loci for Prepulse Inhibition of Startle Identified on Mouse Chromosome 16 Using Chromosome Substitution Strains

Contact Info

Product

Resources

About