The belly rules the nose: feeding state-dependent modulation of peripheral chemosensory responses

Sengupta, Piali

doi:10.1016/j.conb.2012.08.001

Cited by 75 publications

(68 citation statements)

References 58 publications

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“…The underlying mechanism and the potential role for MCs requires further study. On the other hand, the response to food is also partly regulated by neuroendocrine factors including peripheral serotonergic responses 24. Although MCs can secrete and synthesise serotonin from tryptophan and serotonin is a chemotactic molecule for MCs,25 and some adverse reactions to diet in FGIDs involve foods containing serotonin, including cheese, meat, soya beans, cereals, nuts and vegetables,26 the role of MCs in such responses, if any, is mostly ignored.…”

Section: Factors and Mechanisms Underlying MC Activation In The Gutmentioning

confidence: 99%

The role of mast cells in functional GI disorders

Wouters

Vicario

Santos

2015

Gut

268

237

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Functional gastrointestinal disorders (FGIDs) are characterized by chronic complaints arising from disorganized brain-gut interactions leading to dysmotility and hypersensitivity. The two most prevalent FGIDs, affecting up to 16-26% of worldwide population, are functional dyspepsia and irritable bowel syndrome. Their etiopathogenic mechanisms remain unclear, however, recent observations reveal low-grade mucosal inflammation and immune activation, in association with impaired epithelial barrier function and aberrant neuronal sensitivity. These findings come to challenge the traditional view of FGIDs as pure functional disorders, and relate the origin to a tangible organic substrate. The mucosal inflammatory infiltrate is dominated by mast cells, eosinophils and intraepithelial lymphocytes in the intestine of FGIDs. It is well established that mast cell activation can generate epithelial and neuro-muscular dysfunction and promote visceral hypersensitivity and altered motility patterns in FGIDs, postoperative ileus, food allergy and inflammatory bowel disease. This review will discuss the role of mucosal mast cells in the gastrointestinal tract with a specific focus on recent advances in disease mechanisms and clinical management in irritable bowel syndrome and functional dyspepsia.

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Section: Factors and Mechanisms Underlying MC Activation In The Gutmentioning

confidence: 99%

The role of mast cells in functional GI disorders

Wouters

Vicario

Santos

2015

Gut

268

237

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“…Food odors are known to elicit strong innate attraction in D. melanogaster and mechanisms regulating food search behavior are being unraveled [21][22][23][24][25][26][27]. The attraction to food smells is known to be dependent on the nutritional state of the organism [17,24,[28][29][30][31][32]. In D. melanogaster, the strength of synaptic signaling from specific olfactory sensory neurons (OSNs) in the antennae is increased by hunger and regulated by insulin-like peptides (DILPs) [24].…”

Section: Introductionmentioning

confidence: 99%

Food odors trigger an endocrine response that affects food ingestion and metabolism

Lushchak

Carlsson

Nässel

2015

Cell. Mol. Life Sci.

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Food odors stimulate appetite and innate food-seeking behavior in hungry animals. The smell of food also induces salivation and release of gastric acid and insulin. Conversely, sustained odor exposure may induce satiation. We demonstrate novel effects of food odors on food ingestion, metabolism and endocrine signaling in Drosophila melanogaster. Acute exposure to attractive vinegar odor triggers a rapid and transient increase in circulating glucose, and a rapid upregulation of genes encoding the glucagon-like hormone adipokinetic hormone (AKH), four insulin-like peptides (DILPs) and some target genes in peripheral tissues. Sustained exposure to food odors, however, decreases food intake. Hunger-induced strengthening of synaptic signaling from olfactory sensory neurons (OSNs) to brain neurons increases food-seeking behavior, and conversely fed flies display reduced food odor sensitivity and feeding. We show that increasing the strength of OSN signaling chronically by genetic manipulation of local peptide neuromodulation reduces feeding, elevates carbohydrates and diminishes lipids. Furthermore, constitutively strengthened odor sensitivity altered gene transcripts for AKH, DILPs and some of their targets. Thus, we show that food odor can induce a transient anticipatory endocrine response, and that boosted sensitivity to this odor affects food intake, as well as metabolism and hormonal signaling.

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“…Dissecting the mechanisms whereby external and internal contexts of stimuli influence the behavioral outputs of a hardwired circuit might appear a daunting task. However, aided by powerful genetic tools, much progress has recently been made to address this fascinating question in genetic model organisms such as Caenorhabditis elegans and Drosophlia melanogaster (for review, see [1,2,4,7]). Here we will focus on recent advances in neuromodulation of Drosophila innate behavior.…”

Section: Introductionmentioning

confidence: 99%

Modulation of neural circuits: how stimulus context shapes innate behavior in Drosophila

Wang

2014

Current Opinion in Neurobiology

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Summary Remarkable advances have been made in recent years in our understanding of innate behavior and the underlying neural circuits. In particular, a wealth of neuromodulatory mechanisms have been uncovered that can alter the input-output relationship of a hereditary neural circuit. It is now clear that this inbuilt flexibility allows animals to modify their behavioral responses according to environmental cues, metabolic demands and physiological states. Here, we discuss recent insights into how modulation of neural circuits impacts innate behavior, with a special focus on how environmental cues and internal physiological states shape different aspects of feeding behavior in Drosophila.

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The belly rules the nose: feeding state-dependent modulation of peripheral chemosensory responses

Cited by 75 publications

References 58 publications

The role of mast cells in functional GI disorders

The role of mast cells in functional GI disorders

Food odors trigger an endocrine response that affects food ingestion and metabolism

Modulation of neural circuits: how stimulus context shapes innate behavior in Drosophila

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