The Beneficial Effect of Anthocyanidin‐Rich <scp><i>Vitis vinifera</i></scp> L. Grape Skin Extract on Metabolic Changes Induced by High‐Fat Diet in Mice Involves Antiinflammatory and Antioxidant Actions

Costa, G; Santos, Izabelle Barcellos; de, Graziele Freitas; Cordeiro, Viviane Silva Cristino; Costa, Cristiane Aguiar da; Carvalho, Lenize Costa Reis Marins de; Ognibene, Dayane Teixeira; Resende, Ângela Castro; Moura, Roberto Soares de

doi:10.1002/ptr.5898

Cited by 44 publications

(32 citation statements)

References 60 publications

(69 reference statements)

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“…These results are similar to a study with organic and conventional grape juice, in which the groups that consumed the juice had lipid peroxidation reduced in the liver of rats submitted to a high fat diet [19]. Also corroborating with our results, the levels of lipid peroxidation were reduced in the plasma of pregnant sheep in a study using diet supplemented with polyphenols (51). Furthermore, a clinical study with subjects who consumed grape juice for two weeks demonstrated the reduction of TBARS in serum and plasma (52).…”

Section: Discussionsupporting

confidence: 92%

Grape Juice Consumption with or without High Fat Diet during Pregnancy Reduced the Weight Gain and Improved Lipid Profile and Oxidative Stress Levels in Liver and Serum from Wistar Rats

et al. 2018

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The aim of this study was to evaluate the effects of high fat diet with or without grape juice during the pregnancy on gestational weight gain, biochemical parameters, and oxidative stress in plasma and liver from Wistar rats. Forty-nine rats were divided into four groups: control diet group (CD), high fat diet (HFD), grape juice and control diet (PGJCD), and grape juice and high fat diet (PGJHFD). During the treatment the weight gain of the rats was tracked. They had free access to their respective diets during 42 days of treatment. After offspring weaning, the mother rats were euthanized and blood and liver were collected. The high fat diet increased the total cholesterol and triglycerides serum levels as well as carbonyl levels in the liver, however this diet reduced the high-density lipoprotein (HDL) and urea levels in serum. Grape juice consumption reduced gestational body weight gain. In liver, the juice consumption increased sulfhydryl levels and reduced the superoxide dismutase (SOD) activity and TBARS level, in serum the consumption reduced aspartate aminotransferase (AST) and TBARS. We can conclude that the consumption of a diet rich in fat can promotes harmful effects on health during pregnancy, however the consumption of grape juice seems to be an important alternative to prevent oxidative damages and to promote the improvement of health.

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Section: Discussionsupporting

confidence: 92%

Grape Juice Consumption with or without High Fat Diet during Pregnancy Reduced the Weight Gain and Improved Lipid Profile and Oxidative Stress Levels in Liver and Serum from Wistar Rats

et al. 2018

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“…Previous studies showed hyperglycemic effects of BPA both in rat (Hassani, Mehri et al, 2017) and mice (Moghaddam et al, 2015). Oxidative stress, inflammation (Pahlavani et al, 2017), and insulin resistance, which are seen in diabetes or metabolic syndrome, is accompanied with impaired insulin-stimulated proteins (PI3K and p-Akt; da Costa et al, 2017).…”

Section: Effect Of Bpa Resveratrol and Gse On Glycaemia And Insulmentioning

confidence: 99%

Vitis vinifera (grape) seed extract and resveratrol alleviate bisphenol‐A‐induced metabolic syndrome: Biochemical and molecular evidences

Rameshrad

Razavi

Imenshahidi

et al. 2019

Phytotherapy Research

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The mechanisms of bisphenol‐A (BPA)‐induced metabolic syndrome as well as the protective role of grape seed extract (GSE) and resveratrol were investigated. Rats were treated with BPA (0 and 35 mg·kg−1·day−1, gavage) plus resveratrol (25, 50, and 100 mg·kg−1·day−1, i.p.) or GSE (3, 6, 12 mg·kg−1·day−1, i.p.) or vitamin E (200 IU/kg/every other day, i.p.). After 2 months, mean systolic blood pressure, serum lipid profile, glycaemia, and fat index were examined. By enzyme‐linked immunosorbent assay, the serum concentrations of insulin, leptin, adiponectin, and paraoxonase 1, and by real‐time polymerase chain reaction as well as western blotting, key liver elements in cholesterol hemostasis (LDLR, CYP7A1, ABCG5 and 8) and insulin signaling (p‐Akt/Akt and p‐PI3K/PI3K) were measured. BPA increased mean systolic blood pressure, total cholesterol, and low‐density lipoprotein cholesterol and reduced paraoxonase1 and the hepatic expression of both ABCG5 and ABCG8. It increased the body fat index, leptin, adiponectin, insulin, and glycaemia level and decreased the hepatic protein expression of p‐Akt/Akt and p‐PI3K/PI3k. GSE, resveratrol, or vitamin E coadministration along with BPA restored the detrimental effects of BPA in some levels. Herein, the predisposing effects of BPA‐induced metabolic syndrome were restored by GSE and resveratrol, linked to the regulation of insulin signaling, ABCG8 expression, and their antioxidant properties.

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“…The polyphenol-rich extract of Vitis vinifera L. grape skin prevented the obesity induced by HFD through increasing the insulin sensitivity in adipose tissue and skeletal muscle due to increase in AMPK and GLUT4 expression. The observed hypoglycemic and antioxidant effects contributed to the regulation of the lipid profile and adipokines, by favoring the reduction of the inflammation in adipose tissue and weight gain (da Costa et al, 2017). The sesquiterpene germacrone (20 mg/kg/day) was the active molecule of Garcinia cambogia extract, which at concentration of 200 mg/kg/day attenuated hyperlipidemia by alleviating fatty acid synthesis/uptake and improve lipid metabolism by stimulation of FA β-oxidation (Guo and Choung, 2017).…”

Section: In Vivo Studiesmentioning

confidence: 99%

Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic

Vasileva

Marchev

Georgiev

2018

Food and Chemical Toxicology

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Diverse groups of factors are leading to increased weight gain and obesity, such as certain genetic phenotypes, neuroendocrine disturbances, the administration of some drugs, behavioral, social and environmental factors. The progressively escalating rates of overweight and obesity worldwide have led to an introduction of a new term "globesity". Excessive accumulation of body fat and especially of visceral adipose tissue is the main predisposing factor for the development of metabolic syndrome and other obesity related co-morbidities. At the present moment only few pharmacotherapeuticals are used for long-term treatment of obesity acting on narrow target spectra, e.g. pancreatic and gastric lipase inhibition, acting as adrenomimetics or activating the satiety centers in hypothalamus. Plant-based medications that accelerate weight loss, proved to be safe, effective and widely available, would be a preferable alternative for anti-obesity treatments. As plant extracts are multi-component systems they could also act by more than one mechanism, including decreased lipid absorption, decreased energy intake, increased energy expenditure, decreased pre-adipocyte differentiation and proliferation, decreased lipogenesis and increased lipolysis. The current review gives a summary of the risk factors for obesity development and its characteristics consequences. Current treatment options, combining lifestyle changes and conventional treatment with commercial anti-obesity drugs have been described as well. Special emphasis on in vitro, in vivo and human studies, of potential medicinal plant extracts and phytochemicals, such as polyphenols, terpenoids, alkaloids, saponins, able to modulate the molecular pathways and gene/protein expressions related to obesity, have been highlighted.

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The Beneficial Effect of Anthocyanidin‐Rich Vitis vinifera L. Grape Skin Extract on Metabolic Changes Induced by High‐Fat Diet in Mice Involves Antiinflammatory and Antioxidant Actions

Cited by 44 publications

References 60 publications

Grape Juice Consumption with or without High Fat Diet during Pregnancy Reduced the Weight Gain and Improved Lipid Profile and Oxidative Stress Levels in Liver and Serum from Wistar Rats

Grape Juice Consumption with or without High Fat Diet during Pregnancy Reduced the Weight Gain and Improved Lipid Profile and Oxidative Stress Levels in Liver and Serum from Wistar Rats

Vitis vinifera (grape) seed extract and resveratrol alleviate bisphenol‐A‐induced metabolic syndrome: Biochemical and molecular evidences

Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic

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