The beneficial effect of clove essential oil and its major component, eugenol, on erectile function in diabetic rats

Yilmaz‐Oral, Didem; Önder, Alev; Gür, Serap; Carbonell‐Barrachina, Ángel A.; Kaya‐Sezginer, Ecem; Öztekin, Çetin Volkan; Zor, Murat

doi:10.1111/and.13606

Cited by 13 publications

(3 citation statements)

References 36 publications

(59 reference statements)

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“…Microemulsions, in general, have a penetration-enhancing ability owing to their oily nature and small droplet size (8,10). For the formulation in this study, there is an additional enhancement of sexual activity brought about by clove oil, which can help to delay premature ejaculation (9,12).…”

Section: Resultsmentioning

confidence: 99%

Microemulsion: A Potential Approach For transdermal Delivery of Sildenafil Citrate

Alazzo¹,

Alfahad²,

Jasim³

et al. 2023

Mil. Med. Sci. Lett.

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Sildenafil citrate has low oral bioavailability, systemic adverse effects, and a relatively delayed action. These issues may be addressed through direct transdermal delivery to the penis. This study aims to investigate the microemulsion formulation of the drug for effective transdermal delivery. Sildenafil citrate was formulated as a microemulsion using clove oil, dimethyl sulphoxide, phosphate buffer (pH 7), propylene glycol, Tween ® 80, and distilled water. Different proportions of these components were used to create six formulations of the microemulsion (F1-F6), which were then characterised by their physical appearance and clarity, pH, viscosity, conductivity, percent transmission, and droplet size. Furthermore, the stability, content analysis, in-vitro drug release, and transdermal permeation of sildenafil citrate from the generated drug-loaded microemulsions were studied. All prepared formulas contained nano-sized oil droplets (less than 20 nm), and the pH values were within the range of skin pH; however, two formulas were not transparent. Additionally, all formulations were thermodynamically stable, passing freeze-thaw, heating-cooling, and centrifugation tests. Next, the formulas demonstrated zero-order release kinetics, indicating that they can provide a sustained release profile for sildenafil citrate. Finally, the microemulsion formulation exhibited a 2.8-fold enhancement in skin permeation compared with that of the sildenafil citrate suspension. The prepared microemulsions demonstrated beneficial physical properties and skin permeation profiles that are promising for the local administration of sildenafil citrate.

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Section: Resultsmentioning

confidence: 99%

Microemulsion: A Potential Approach For transdermal Delivery of Sildenafil Citrate

Alazzo¹,

Alfahad²,

Jasim³

et al. 2023

Mil. Med. Sci. Lett.

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“…Spectral analysis of essential oils from S. aromaticum revealed several beneficial bioactive compounds, including eugenol, β-caryophyllene, vanillin, crategolic acid (maslinic acid), kaempferol, rhamnetin, eugenitin, eugenin, ellagic acid, gallic acid, biflorin, myricetin, campesterol, stigmasterol, oleanolic acid, quercetin, carvacrol, α-pinene, limonene, p-cymene, 1,8-cineole, phenethyl alcohol, benzyl acetate, methyl chavicol, α-terpineol, linalyl acetate, and nerol. 216,217 Of these bioactive, eugenol is the most predominant, with a relative abundance of 90.45% in S. aromaticum . In collagen-induced arthritis (CIA) model to investigate the potential role of eugenol in the management of human arthritis, eugenol (100 μg) suppressed mononuclear cell infiltration into the knee joints of arthritic mice.…”

Section: Indigenous Nigerian Medicinal Plants Whose Bioactive Compoun...mentioning

confidence: 99%

Indigenous Nigeria medicinal herbal remedies: A potential source for therapeutic against rheumatoid arthritis

Arunsi

Chioma

Etusim

et al. 2022

Exp Biol Med (Maywood)

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Rheumatoid arthritis (RA) is a debilitating disease associated with locomotion impairment, and conventional therapeutic drugs are not optimal for managing RA. There is an avalanche of medications used for the management of RA. Still, studies have shown that they are associated with severe side effects, including hepatotoxicity, retinopathy, and cardiotoxicity disorders of the central nervous system (CNS), skin, blood, and infections. Complementary and alternative medicine (CAM) is currently gaining attention as a novel panacea for managing debilitating diseases, such as RA. Nigerian folk herbal remedies are replete with a plethora of curative medicine, albeit unvalidated scientifically but with seemingly miraculous provenance. Studies of the identification of bioactive compounds present in these botanicals using advanced spectral analytical techniques have enhanced our understanding of the role of Nigerian herbal remedies in the treatment and management of RA. Interestingly, experimental studies abound that the bioactive compounds present in the extracts of plant botanicals protected animals from the development of RA in different experimental models and reduced the toxicity associated with conventional therapeutics. Validated mechanisms of RA amelioration in human and animal models include suppression of the expression of NF-κB, IL-1β, TNF-α, IL-6, IL-8, IL-17, IL-23, chemokines, TGF-β, RANKL, RANK, iNOS, arginase, COX-2, VEGFA, VEGFR, NFATC1, and TRAP in the synoviocytes. Decreased ROS, NO, MDA, carbonyl groups, and PGE2 in the synovial fluid increased the expression of PPARα/γ; antioxidant and anti-inflammatory molecules also improve RA etiology. In this mini-review, we discuss the global burden of RA, the novel role of plant-based botanicals as potential therapeutics against signaling pathways in RA. Also addressed is the possible repurposing/reprofiling of plant botanicals to increase their therapeutic index among RA patients that patronize traditional healers in Nigeria with a global projection.

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“…In an experiment, it has been showed that Sesame oil with 20% of feed intake has showed a protective effect in the brain to enhance the immunity of rats against the oxidative stress [39]. It has been identified that Clove oil has improved the immune response and activated relaxation signal pathway for more immunity enhancement in rats[42]. It was also observed that dietary supplements with 0.5%, 1% and 1.5% of clove oil were useful for growth, disease resistance and strong immunity in Nile tilapia[43].…”

mentioning

confidence: 99%

Comparative effects of sesame oil and clove oil on growth performance, blood profile and immunity of rabbit (Oryctolagus cuniculus)

Iqbal¹

2022

PAB

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Essential oils are being used to improve health due to their high nutritive value. In this study, the comparative effects of Sesame oil and Clove oil were assessed on growth performance, blood profile and immunity of male rabbits. A total of 108 male rabbits were divided into 3 treatment groups; Treatment group A (Sesame oil), Treatment group B (Clove oil), Treatment group C (Sesame oil + Clove oil). Each treatment group was further divided into 4 subgroups according to dosage design of oils. The control group was untreated, while treatment dose for groups A and B was divided into 3 different concentrations; 0.1, 0.2 and 0.3ml/kilogram Body Weight. Whereas, the treatment concentrations for group C were as; 0.1+0.1, 0.2+0.2 and 0.3+0.3ml/kilogram Body Weight of oils for 1-1.5kg of rabbits. The rabbits were managed in proper caging under controlled conditions of photoperiod (12 light: 12 dark cycles) 23±2ºC of temperature. The selected dose concentration of each oil was administered orally and once a day for six weeks. The results showed that both oils had significantly enhanced the growth performance and reduced the Feed Conversion Ratio. The hematological parameters were increased in all treatment groups, respectively. The Enzyme-linked Immunosorbent Assay for Rabbit Hemorrhagic Disease Virus also showed a significant increase in antibody titer level. The study showed that Sesame oil and Clove oil as dietary supplements have significantly (p<0.05) improved overall performance of male rabbits. The current study clearly indicated that both oils could be a better choices for health purposes.

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The beneficial effect of clove essential oil and its major component, eugenol, on erectile function in diabetic rats

Cited by 13 publications

References 36 publications

Microemulsion: A Potential Approach For transdermal Delivery of Sildenafil Citrate

Microemulsion: A Potential Approach For transdermal Delivery of Sildenafil Citrate

Indigenous Nigeria medicinal herbal remedies: A potential source for therapeutic against rheumatoid arthritis

Comparative effects of sesame oil and clove oil on growth performance, blood profile and immunity of rabbit (Oryctolagus cuniculus)

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