The Beneficial Effects of Combined Grape Pomace and Omija Fruit Extracts on Hyperglycemia, Adiposity and Hepatic Steatosis in db/db Mice: A Comparison with Major  Index Compounds

Cho, Su-Jung; Park, Hae-Jin; Jung, Un Ju; Kim, Hye Jin; Moon, Byoung Seok; Choi, Myung‐Sook

doi:10.3390/ijms151017778

Cited by 18 publications

(17 citation statements)

References 32 publications

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“…It is supposed that some flavonoids and polyphenols in GPE+OFE may have synergistic effects via their interaction, although we did not determine it in the present study. This hypothesis is supported by a previous our study in which the effects of GPE+OFE were compared with those of resveratrol and schizandrin mixture (RS), which is a mixture of the major index components of GPE+OFE [ 47 ]. GPE+OFE have more protective effect on hyperglycemia, adiposity and hepatic steatosis in type 2 diabetic mice than RS [ 47 ].…”

Section: Discussionsupporting

confidence: 55%

“…This hypothesis is supported by a previous our study in which the effects of GPE+OFE were compared with those of resveratrol and schizandrin mixture (RS), which is a mixture of the major index components of GPE+OFE [ 47 ]. GPE+OFE have more protective effect on hyperglycemia, adiposity and hepatic steatosis in type 2 diabetic mice than RS [ 47 ]. Another possibility is that other unknown active components present in extracts of GPE+OFE also play important in their biological effects.…”

Section: Discussionsupporting

confidence: 55%

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Dual effects of a mixture of grape pomace (Campbell Early) and Omija fruit ethanol extracts on lipid metabolism and the antioxidant defense system in diet-induced obese mice

et al. 2015

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BACKGROUND/OBJECTIVESWe investigated the effects of a combination of grape pomace (Vitis labrusca, Campbell Early) and Omija fruit (Schizandra chinensis, Baillon) ethanol extracts on lipid metabolism and antioxidant defense system in diet-induced obese mice.MATERIALS/METHODSForty male C57BL/6J mice were divided into four groups and fed high-fat diet (control group, CON) or high-fat diet added 0.5% grape pomace extract (GPE), 0.05% Omija fruit extract (OFE) or 0.5% GPE plus 0.05% OFE (GPE+OFE) for 12 weeks.RESULTSIn contrast to the GPE- or OFE-supplemented groups, the GPE+OFE group showed significantly lower body weight and white adipose tissue weights than the CON group. Moreover, GPE+OFE supplementation significantly decreased plasma total cholesterol and increased the plasma HDL-cholesterol/total-cholesterol ratio (HTR) compared to the control diet. The hepatic triglyceride level was significantly lower in the GPE+OFE and GPE groups by increasing β-oxidation and decreasing lipogenic enzyme compared to the CON group. Furthermore, GPE+OFE supplementation significantly increased antioxidant enzyme activities with a simultaneous decrease in liver H2O2 content compared to the control diet.CONCLUSIONSTogether our results suggest that supplementation with the GPE+OFE mixture may be more effective in improving adiposity, lipid metabolism and oxidative stress in high-fat diet-fed mice than those with GPE and OFE alone.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionsupporting

confidence: 55%

Dual effects of a mixture of grape pomace (Campbell Early) and Omija fruit ethanol extracts on lipid metabolism and the antioxidant defense system in diet-induced obese mice

et al. 2015

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“…Phytochemicals are known to possess antioxidant properties with effective anti-inflammatory, antiallergic, hepatoprotective, antithrombotic, antiviral, and anticarcinogenic activities ( 7 – 9 ). Among them, polyphenols such as resveratrol, catechins, and anthocyanins are of great interest due to their wide distribution in plants and potent health-promoting activities ( 10 – 12 ). Treatments with phytochemicals obtained from various sources have been demonstrated to regulate the levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) in HFD-fed rats ( 13 – 15 ).…”

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confidence: 99%

Effect ofHibiscus sabdariffaextract on high fat diet–induced obesity and liver damage in hamsters

Huang¹,

Chang²,

Kao

et al. 2015

Food & Nutrition Research

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BackgroundObesity is a chronic metabolic disorder associated with an increase in adipogenesis and often accompanied with fatty liver disease.ObjectiveIn this study, we investigated the anti-obesity effects of Hibiscus sabdariffa water extract (HSE) in vivo.MethodEight-weeks-old male mice were divided into six groups (n=8 per group) and were fed either normal feed, a high fat diet (HFD), HFD supplemented with different concentrations of HSE, or HFD supplemented with anthocyanin. After 10 weeks of feeding, all the blood and livers were collected for further analysis.ResultsMesocricetus auratus hamster fed with a high-fat diet developed symptoms of obesity, as determined from their body weight change and from their plasma lipid levels. Meanwhile, HSE treatment reduced fat accumulation in the livers of hamsters fed with HFD in a concentration-dependent manner. Administration of HSE reduced the levels of liver cholesterol and triglycerides, which were elevated by HFD. Analysis of the effect of HSE on paraoxonase 1, an antioxidant liver enzyme, revealed that HSE potentially regulates lipid peroxides and protects organs from oxidation-associated damage. The markers of liver damage such as serum alanine aminotransferase and aspartate aminotransferase levels that were elevated by HFD were also reduced on HSE treatment. The effects of HSE were as effective as treatment with anthocyanin; therefore the anthocyanins present in the HSE may play a crucial role in the protection established against HFD-induced obesity.ConclusionsIn conclusion HSE administration constitutes an effective and viable treatment strategy against the development and consequences of obesity.

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“…GP alone exerted a significant anti-postprandial hyperglycemic effect in diabetic mice [22], while GPOF lowered fasting hyperglycemia in type 2 diabetic db/db [13]. It is important to identify that GPOF can prevent blood glucose rise in DIO condition in the early stage (12 weeks).…”

Section: Discussionmentioning

confidence: 99%

“…Omija (Schisandrachinensis), another polyphenol-rich plant that has been used in traditional Chinese medicine and pharmacotherapy of European and other countries, plays an important role in lowering blood glucose level and regulating the endocrine and immune systems and antioxidant enzyme activities [10,11]. We previously demonstrated that combined extracts of grape pomace (GP) and GP plus omija fruit (GPOF) showed anti-obesity and anti-inflammatory effects in diet-induced obese (DIO) mice [12] and an anti-diabetes effect in db/db mice [13]. The aims of the present study were to examine whether GPOF has blood glucose-and oxidative stress-lowering effects in mice fed an obesogenic diet and compare its effects with those of GP.…”

Section: Introductionmentioning

confidence: 99%

Mixture of Ethanol Extract of Grape Pomade and Omija Fruit Prevents Hyperglycemia and Alleviates Oxidative Stress in Mice Fed an Obesogenic Diet

Jung¹

2015

J Diabetes Metab

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Background: A high-fat diet (HFD) is thought to be one of the main environmental factors for obesity in which oxidative stress is an important pathogenic mechanism of obesity-associated metabolic syndrome including diabetes. Polyphenol-rich food plants are known to improve obesity-related diseases. The aim of this study was to investigate the effects of grape pomace (GP) and GP plus omija fruit (GPOF) on hyperglycemia and oxidative stress in diet-induced obese (DIO) mice. Methods: Male C57BL/6J mice were fed an HFD with GP (0.5%, w/w) or GPOF (0.5% GP plus 0.05% omija fruit, w/w) for 12 weeks. One gram of GP contains 0.26 mg of total flavonoid and 0.475 mg of total polyphenol, while 1 g of GPOF contains 0.2635 mg of total flavonoid and 0.491 mg of total polyphenol. Results: GP and GPOF significantly lowered fasting blood glucose level and insulin/glucagon ratio compared to HFD but increased plasma glucagon level. Supplementation with GP or GPOF improved glucose tolerance and the expressions of pancreatic insulin and glucagon while preserving α-and β-cells. GPOF in particular seems to improve insulin sensitivity by reducing plasma insulin and homeostasis model assessment of insulin resistance levels. Erythrocyte glutathione peroxidase and glutathione reductase activities were significantly lower in the GPOF group than in the HFD group along with decreases in erythrocyte hydrogen peroxide and thiobarbituric acid-reactive substance levels. Conclusion: These results suggest that GPOF, which is rich in flavonoids, may be beneficial in preventing an increase in the risk factors for diabetes in obesity, including fasting hyperglycemia, glucose intolerance, and oxidative stress.

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The Beneficial Effects of Combined Grape Pomace and Omija Fruit Extracts on Hyperglycemia, Adiposity and Hepatic Steatosis in db/db Mice: A Comparison with Major Index Compounds

Cited by 18 publications

References 32 publications

Dual effects of a mixture of grape pomace (Campbell Early) and Omija fruit ethanol extracts on lipid metabolism and the antioxidant defense system in diet-induced obese mice

Dual effects of a mixture of grape pomace (Campbell Early) and Omija fruit ethanol extracts on lipid metabolism and the antioxidant defense system in diet-induced obese mice

Effect ofHibiscus sabdariffaextract on high fat diet–induced obesity and liver damage in hamsters

Mixture of Ethanol Extract of Grape Pomade and Omija Fruit Prevents Hyperglycemia and Alleviates Oxidative Stress in Mice Fed an Obesogenic Diet

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