The benefit of adjuvant chemotherapy combined with postoperative radiotherapy for endometrial cancer: a meta-analysis

A multicenter analysis of adjuvant therapy after surgery for stage IIIC endometrial adenocarcinoma: A Korean Radiation Oncology Group study (KROG 13-17)

“…A recent meta-analysis showed that the CTRT group in advanced stage endometrial cancer had a more significant survival benefit compared to the RT group [13]. However, advanced endometrial cancer represents a heterogeneous group of patients in terms of histologic grade; extent of nodal involvement; stage IV; uterine serosal, adnexal, vaginal or parametrial involvement; and histologic subtype, such as serous or clear cell carcinoma.…”

Retrospective Analysis of Adjuvant Therapy in Intermediate and High Risk Endometrial Cancer Patients

“…Park et al performed a meta-analysis in 2013 enrolled 6 articles suggested that the chemotherapy plus radiotherapy group had a more significant survival benefit compared to that of the radiotherapy group in advanced stage EC with the OS hazard ratios (HR) 0.53 and PFS HR 0.54 [11] The sandwich protocol has also been reported with favorable survival outcomes in several recent studies. Geller et al reported a 3-year PFS and OS of 80% and 88%, respectively, on patients with stage II-IV endometrial cancer [16].…”

“…Data of 46 patients with high and intermediate risk EC according to GOG risk stratification [11] presenting to KCCC were retrospectively analyzed, all slides were reviewed by a dedicated experienced pathologist to confirm diagnosis and patients with synchronous ovarian cancer were excluded from this analysis. A written informed consent was approved by the Institutional Review board (IRB) ethical committee of the KCCC.…”

Staging for endometrial cancer: The controversy around lymphadenectomy – Can this be resolved?

“…The benefit of chemotherapy in early stage EC has been poorly investigated 92,93 . In Randall et al trial comparing whole-abdominal irradiation and doxorubicin-cisplatin chemotherapy in women with stage III or IV EC having a maximum of 2 cm of postoperative residual disease, chemotherapy significantly improved survival compared with whole-abdominal irradiation 94 .…”

“…Since approximately half of patients where stage III because of metastatic LN (FIGO 1988 Stage IIIC), these results constitute a strong argument for adequate systematic surgical staging (including LN assessment) and justify to deliver chemotherapy in patients with metastatic LN 20,93,95 . This study is pivotal since it showed for the first time that EC is a chemosensitive …”