The Benefit of Entropy in the Management of General Anaesthesia for the Patients With Metabolic Disorders

Timar, Călin

doi:10.31925/farmacia.2021.5.11

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…Compared to fentanyl combined with ropivacaine for epidural patient-controlled analgesia, there was no considerable difference in mean arterial pressure, heart rate, or foetal heart rate in women treated with 1:0.5 μg/mL Dex combined with ropivacaine for epidural patient-controlled analgesia. The normal foetal heart rate ranges from 110 to 160 beats per minute [22,23]. The foetal heart rate of puerperae with different analgesia modes was within the normal range, while the foetal heart rate of puerperae with a large dose of Dex assisted by controlled epidural analgesia was reduced.…”

Section: Comparison Of Serum Levels Of Il-6 and Crp In Perinatal Part...mentioning

confidence: 96%

The Beneficial Effect of Dexmedetomidine Combined With Epidural-Controlled Analgesia on the Reduction of Fever and Inflammation During Labour in Term-Pregnant Women

LI¹

2023

FARMACIA

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In this study, we investigated the impact of epidural-controlled analgesia and dexmedetomidine (Dex) epidural analgesia on fever and outcomes for the mother and infant in full-term pregnancies. A total of 605 first-term pregnant women were randomly divided into Group A (n = 300), Group B (n = 300), and Group C (n = 5). They were given 1 μg/mL fentanyl + 0.1% ropivacaine (Group A), 1:0.5 μg/mL Dex + 0.1% ropivacaine (Group B), and 2:1 μg/mL Dex + 0.1% ropivacaine (Group C). Before epidural labour analgesia (T0), 10 min after analgesia (T1), 30 min after analgesia (T2), immediately after foetal delivery (T3), 10 min after foetal delivery (T4), Two hours after foetal delivery (T5), and 24 h after foetal delivery (T6), the mean arterial pressure, heart rate, foetal heart rate, pain visual analogue scale (VAS) score, sedation score, lower limb motor block degree, maternal satisfaction, sedation drug used, and fever were recorded. The findings indicate that Group B exhibited a reduction in the quantity of sedative drugs administered and added, as well as a decrease in mean arterial pressure at T3. The VAS score at T3 and T4 decreased, while the maternal satisfaction score increased. Furthermore, the fever rate and serum levels of IL-6 and CRP decreased at T4, T5, and T6 in Group B compared to Group A. There were no significant differences in maternal heart rate, foetal heart rate, Ramsay score, or Bromage score between Group A and Group B. RezumatÎn acest studiu, am investigat impactul analgeziei epidurale controlate și al analgeziei epidurale cu dexmedetomidină (Dex) asupra febrei și consecințele asupra mamei și nou-născutului. Un total de 605 femei însărcinate au fost împărțite aleator în Grupul A (n = 300), Grupul B (n = 300) și Grupul C (n = 5). Acestora li s-a administrat 1 μg/mL fentanil + 0,1% ropivacaină (Grupul A), 1:0,5 μg/mL Dex + 0,1% ropivacaină (Grupul B), și 2:1 μg/mL Dex + 0,1% ropivacaină (Grupul C). Înainte de analgezia epidurală în travaliu (T0), la 10 minute după analgezie (T1), la 30 de minute după analgezie (T2), imediat după nașterea fătului (T3), la 10 minute după nașterea fătului (T4), la două ore după nașterea fătului (T5) și la 24 de ore după nașterea fătului (T6), au fost măsurați parametrii clinici specifici la mamă și la nou-născut, raportat la medicamentul de sedare utilizat. Constatările indică faptul că Grupul B a prezentat o reducere a cantității de medicamente sedative administrate, precum și o scădere a presiunii arteriale medii la T3. Scorul VAS la T3 și T4 a scăzut, în timp ce scorul de satisfacție maternă a crescut. Mai mult, rata febrei și nivelurile serice ale IL-6 și CRP au scăzut la T4, T5 și T6 în Grupul B, în comparație cu Grupul A. Nu au existat diferențe semnificative în ceea ce privește frecvența cardiacă maternă, frecvența cardiacă fetală, scorul Ramsay sau scorul Bromage între Grupul A și Grupul B. În concluzie, analgezia epidurală controlată cu dexmedetomidină s-a dovedit sigură la mamă și nou-născut, iar efectele analgezic și antipiretic au fost evidente.

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Section: Comparison Of Serum Levels Of Il-6 and Crp In Perinatal Part...mentioning

confidence: 96%

The Beneficial Effect of Dexmedetomidine Combined With Epidural-Controlled Analgesia on the Reduction of Fever and Inflammation During Labour in Term-Pregnant Women

LI¹

2023

FARMACIA

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“…Extubation of the trachea is a severe body stimulus, which will cause a series of stress responses in the body, such as increased blood pressure and increased heart rate [13,14]. It may be related to various factors such as shallow anaesthesia during tracheal extubation, mechanical irritation of the tracheal tube, wound pain and sputum suction operation [15,16]. It can cause many complications during extubation, such as laryngospasm, vomiting and aspiration of stomach contents [17].…”

Section: Groupmentioning

confidence: 99%

Influence of Dexmedetomidine on Clinical Efficacy of General Anesthesia and Stress Response in Children

LIANG¹

2022

FARMACIA

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This study was aimed to explore the effect of dexmedetomidine (DEX) nose drops on paediatric general anaesthesia in the resuscitation room and its influence on children's postoperative stress. Sixty-eight children undergoing general anaesthesia were enrolled. They were randomly divided into two groups according to admission, with 34 cases in each group. Children in the experimental group received DEX at a 1µg/kg dose as nasal drops, combined with sevoflurane (SEV) anaesthesia. Children in the control group received 0.4 mL saline as nasal drops, combined with SEV anaesthesia. Mean arterial pressure (MAP) and heart rate (HR) were recorded before induction of anaesthesia (T0), during extubation (T1), 5 min (T2), and 15 min after extubation (T3). In addition, venous blood was sampled at each of the above time points to determine the plasma epinephrine (E), norepinephrine (NE), and cortisol (Cor) levels to evaluate the postoperative stress response. The incidence of adverse reactions in the two groups was counted. The rate of crying at T1, restlessness after awakening, and adverse reactions were significantly reduced in children from the experimental group compared with the control group. The induction time of anaesthesia in children in the experimental group was significantly decreased compared with the control group. There was no considerable difference in the awakening time of the two groups of children, and the stay time in the post-anaesthesia care unit (PACU) was not extended. In addition, the children in the experimental group had lower MAP and HR at the time of extubation and 5 minutes after extubation compared with the control group. At T1 and T2, the changes of plasma E, NE, and Cor in children from the experimental group were significantly decreased compared with the levels in the control group. RezumatAcest studiu și-a propus să exploreze efectul picăturilor nazale cu dexmedetomidină (DEX) asupra anesteziei generale pediatrice și influența acestuia asupra stresului postoperator al copiilor. În studiu au fost incluși 68 de copii, randomizați în două grupuri. Copiii din grupul experimental au primit DEX la o doză de 1 µg/kg sub formă de picături nazale, în combinație cu anestezie cu sevofluran (SEV). Copiii din grupul de control au primit 0,4 mL ser fiziologic sub formă de picături nazale, combinate cu anestezie SEV. S-au înregistrat valorile tensiunii arteriale medii (MAP) și frecvența cardiacă (HR) înainte de inducerea anesteziei (T0), în timpul extubației (T1), la 5 minute (T2) și la 15 minute după extubare (T3). În plus, s-au recoltat probe de sânge pentru fiecare dintre momentele de mai sus pentru a determina nivelurile plasmatice de epinefrină (E), norepinefrină (NE) și cortizol (Cor), în scopul evaluării răspunsului la stres postoperator. S-a evaluat, de asemenea, incidența reacțiilor adverse în cele două grupuri. Timpul de inducere a anesteziei la copiii din grupul experimental a fost semnificativ redus comparativ cu grupul de control. Nu a existat o diferență considerabilă în timpul de trezire al ce...

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The Benefit of Entropy in the Management of General Anaesthesia for the Patients With Metabolic Disorders

Cited by 2 publications

References 11 publications

The Beneficial Effect of Dexmedetomidine Combined With Epidural-Controlled Analgesia on the Reduction of Fever and Inflammation During Labour in Term-Pregnant Women

The Beneficial Effect of Dexmedetomidine Combined With Epidural-Controlled Analgesia on the Reduction of Fever and Inflammation During Labour in Term-Pregnant Women

Influence of Dexmedetomidine on Clinical Efficacy of General Anesthesia and Stress Response in Children

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