The benefits of hormone replacement therapy in pre-menopausal women with oestrogen deficiency on haemodialysis

Matuszkiewicz‐Rowińska, Joanna; Skórzewska, Katarzyna; Radowicki, Stanisław; Sokalski, Antoni; Przedlacki, J; Niemczyk, Stanisław; Włodarczyk, D; Puka, J; Świtalski, Marek

doi:10.1093/ndt/14.5.1238

Cited by 67 publications

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“…In the current study, short-term HRT administration decreased urinary calcium excretion, a marker of bone turnover, and increased BMD at the spine, femoral neck, and distal radius, consistent with the known short-and longterm bone antiresorptive effects of estrogens or estrogens plus progestins in estrogen-deficient young (45,46) and middle-aged (22,26,47) or older (23,25,48,49) women.…”

Section: Discussionsupporting

confidence: 85%

Growth Hormone and Sex Steroid Effects on Bone Metabolism and Bone Mineral Density in Healthy Aged Women and Men

Christmas¹,

O'Connor²,

Harman³

et al. 2002

The Journals of Gerontology Series A: Biological Sciences and M

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Section: Discussionsupporting

confidence: 85%

Growth Hormone and Sex Steroid Effects on Bone Metabolism and Bone Mineral Density in Healthy Aged Women and Men

Christmas¹,

O'Connor²,

Harman³

et al. 2002

The Journals of Gerontology Series A: Biological Sciences and M

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“…HRT with estrogens may positively affect sexual desire and may prevent loss of bone mass in postmenopausal women with ESRD. 36 More recently alternatives to HRT such as the selective estrogen receptor modulators (SERMs) have been proposed because they have shown the benefits of estrogen on bone and serum lipid levels, without its adverse effects on the breast and endometrium in nonuremic women. 37…”

Section: Treatment Of Sexual Dysfunction In Ckd Womenmentioning

confidence: 99%

Endocrine Complications of Chronic Kidney Disease

Singh

Raed

Kari

2015

Chronic Renal Disease

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“…In a preliminary study from Poland, 13 postmenopausal women with low estradiol levels (o30 pg ml À1 ) were administered transdermal estradiol with the cyclic addition of noretisterone acetate for 12 months. 84 Compared with baseline measurements, BMD increased significantly, but only in L2-L4. Whether this increase in BMD will decrease the long-term risk of fracture will be difficult to evaluate owing to the presence of renal osteodystrophy in the ESRD population.…”

Section: Bone Disease In Postmenopausal Women With Ckdmentioning

confidence: 85%

Chronic kidney disease in postmenopausal women

Suzuki

Kondo

2011

Hypertens Res

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Menopause is derived from the Greek words men (month) and pauses (cessation) and means permanent cessation of menstruation after the loss of ovarian activity. Chronic kidney disease (CKD) has recently been associated with cardiovascular events in several studies. CKD patients have a heavy burden of traditional cardiovascular risk factors in addition to a range of nontraditional risk factors such as inflammation and abnormal metabolism of calcium and phosphate. In this review, the association of CKD and cardiovascular disease (CVD), as well as of osteoporosis in postmenopausal women is discussed. CKD mineral and bone disorder, characterized by disturbances of calcium/phosphate/parathyroid hormone, bone abnormalities and vascular and soft tissue calcification, is highly prevalent in CKD and is a strong, independent predictor of bone fracture, CVD and death. Estrogen has been shown to: (a) decrease the expression of angiotensin type 1 receptors in vasculature and kidneys; (b) reduce the expression and activity of angiotensin-converting enzyme, and (c) cause the release of angiotensinogen substrate from the liver. However, the degree of activation or suppression of the renin-angiotensin-aldosterone system by estrogen has not been clearly established. Clinical data on the effects of estrogen therapy on bone mineral densities are extremely limited in the ESRD population. CVD is the most common cause of death in postmenopausal women with CKD and many contributing factors have been explored. INTRODUCTIONMenopause is derived from the Greek words men (month) and pauses (cessation) and means permanent cessation of menstruation after the loss of ovarian activity. Clinically, menopause is defined as the absence of menstruation for 12 months. 1 In clinical medicine, it is well known that menopause is associated with accelerated progression of vascular diseases and osteoporosis as a long-term health risk in women. Indeed, menopausal status increases the risk of cardiovascular disease (CVD) by more than three-fold in women with normal kidney function. 2 Several factors such as the prevalence of hypertension, 3 diabetes, 4 dyslipidemia 5 and so on are known contributors to CVD. In addition to these factors, several studies reveal that chronic kidney disease (CKD) is closely related with CVD events. 6-9 Moreover, Perticone et al. 10 have recently demonstrated that the reduction of estimated glomerular filtration rate (GFR) was associated with the increased risk of death and CVD events, independently of traditional CV risk factors, menopause duration and presence of metabolic syndrome.In addition to these risks in CVD, women lose an average of 25 percent of their bone mass from the time of menopause to age 60, due in large part to the loss of estrogen. Over time, this loss of bone mass can lead to osteoporosis and its related fractures are a serious problem affecting postmenopausal women. 11 Recently, two serious sequels of menopause have been closely associated with CKD. CKD is associated with accelerated progression of CVD, per...

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The benefits of hormone replacement therapy in pre-menopausal women with oestrogen deficiency on haemodialysis

Cited by 67 publications

References 0 publications

Growth Hormone and Sex Steroid Effects on Bone Metabolism and Bone Mineral Density in Healthy Aged Women and Men

Growth Hormone and Sex Steroid Effects on Bone Metabolism and Bone Mineral Density in Healthy Aged Women and Men

Endocrine Complications of Chronic Kidney Disease

Chronic kidney disease in postmenopausal women

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