The benefits of oestrogens on postprandial lipid metabolism are lost in post‐menopausal women with Type 2 diabetes

Masding, Michael G; Stears, Anna; Burdge, Graham C.; Wootton, Stephen A.; Sandeman, Derek D.

doi:10.1111/j.1464-5491.2006.01867.x

Cited by 15 publications

(11 citation statements)

References 25 publications

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“…There was no significant difference in survival between the two genders in our data, which conflicts with previously reported all‐age population data; this likely reflects the older Medicare patient population that we analyzed. Postmenopausal women have been shown to lose health advantages in multiple areas over men once they reach this age bracket . Our data confirms both prior sinonasal cancer studies' findings of racial disparity in survival …”

Section: Discussionsupporting

confidence: 88%

Determinants of racial differences in survival for sinonasal cancer

Patel

Chen

et al. 2016

The Laryngoscope

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Section: Discussionsupporting

confidence: 88%

Determinants of racial differences in survival for sinonasal cancer

Patel

Chen

et al. 2016

The Laryngoscope

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“…Postmenopausal women with heterozygous FH exhibit abnormal postprandial TG response compared with premenopausal FH women 35 . Postmenopausal estrogen therapy enhances the clearance of chylomicrons and chylomicron remnants 36 , but this beneficial effect is not observed in post-menopausal diabetic women 37 . In subjects with normal fasting TG levels, the postprandial concentration of chylomicron remnants is higher in normolipidemic women with CAD compared with matched controls without CAD 33 .…”

Section: Gender Menopausal Statusmentioning

confidence: 99%

Postprandial lipemia as a cardiometabolic risk factor

Pirillo

Norata

Catapano

2014

Current Medical Research and Opinion

104

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High levels of fasting circulating triglycerides (TG) represent an independent risk factor for cardiovascular disease. In western countries, however, people spend most time in postprandial conditions, with continuous fluctuation of lipemia due to increased levels of TG-rich lipoproteins (TRLs), including chylomicrons (CM), very low density lipoproteins (VLDL), and their remnants. Several factors contribute to postprandial lipid metabolism, including dietary, physiological, pathological and genetic factors. The presence of coronary heart disease, type 2 diabetes, insulin resistance and obesity is associated with higher postprandial TG levels compared with healthy conditions; this association is present also in subjects with normal fasting TG levels. Increasing evidence indicates that impaired metabolism of postprandial lipoproteins contributes to the pathogenesis of coronary artery disease, suggesting that lifestyle modifications as well as pharmacological approaches aimed at reducing postprandial TG levels might help to decrease the cardiovascular risk.

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“…Epidemiological studies have demonstrated that the presence of postprandial hypertriglyceridemia poses an independent risk for coronary atherosclerosis [1–7]. Furthermore, the efficiency with which the body manages incoming dietary lipid can modulate disease risk in other chronic conditions such as obesity [8], type 2 diabetes [9,10], and non-alcoholic fatty liver disease, NAFLD [11]. Indeed, if poor metabolism of dietary triglyceride (TG) leads to ectopic lipid deposition, postprandial events may contribute more to disease development than currently appreciated.…”

Section: Introductionmentioning

confidence: 99%

Postprandial metabolism of meal triglyceride in humans

Lambert¹,

Parks²

2012

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

150

104

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The intake of dietary fat above energy needs has contributed to the growing rates of obesity worldwide. The concept of disease development occurring in the fed state now has much support and dysregulation of substrate flux may occur due to poor handling of dietary fat in the immediate postprandial period. The present paper will review recent observations implicating cephalic phase events in the control of enterocyte lipid transport, the impact of varying the composition of meals on subsequent fat metabolism, and the means by which dietary lipid carried in chylomicrons can lead to elevated postprandial non-esterified fatty acid concentrations. This discussion is followed by an evaluation of the data on quantitative meal fat oxidation at the whole body level and an examination of dietary fat clearance to peripheral tissues — with particular attention paid to skeletal muscle and liver given the role of ectopic lipid deposition in insulin resistance. Estimates derived from data of dietary-TG clearance show good agreement with clearance to the liver equaling 8–12% of meal fat in lean subjects and this number appears higher (10–16%) in subjects with diabetes and fatty liver disease. Finally, we discuss new methods with which to study dietary fatty acid partitioning in vivo. Future research is needed to include a more comprehensive understanding of 1) the potential for differential oxidation of saturated versus unsaturated fatty acids which might lead to meaningful energy deficit and whether this parameter varies based on insulin sensitivity, 2) whether compartmentalization exists for diet-derived fatty acids within tissues vs. intracellular pools, and 3) the role of reduced peripheral fatty acid clearance in the development of fatty liver disease. Further advancements in the quantitation of dietary fat absorption and disposal will be central to the development of therapies designed to treat diet-induced obesity. This article is part of a Special Issue entitled Triglyceride Metabolism and Disease.

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The benefits of oestrogens on postprandial lipid metabolism are lost in post‐menopausal women with Type 2 diabetes

Cited by 15 publications

References 25 publications

Determinants of racial differences in survival for sinonasal cancer

Determinants of racial differences in survival for sinonasal cancer

Postprandial lipemia as a cardiometabolic risk factor

Postprandial metabolism of meal triglyceride in humans

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