The Bf system in diabetes-gene interaction or linkage disequilibrium?

Wolf, Eva; Cudworth, A G; Markwick, J.R.; Gorsuch, A.N.; Spencer, K M; Bodansky, H J

doi:10.1007/bf00254834

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…E-mail: loranne.agius@ncl.ac.uk Abbreviations: CPT I, carnitine palmitoyltransferase I; FA, fatty acid; TAG, triacylglycerol; etomoxir, 2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate; POCA, 2-[5-(4-chlorophenyl)pentyl]oxirane-2-carboxylate (clomoxir); TDGA, methyl tetradecyl glycidate (palmoxirate); MEM, minimal essential medium. delayed increase in [triacylglycerol] in the blood in starved and diabetic rats [5,6] but not in normal rats [5]. This triglyceridemia has raised questions on use of these drugs for treatment of NIDDM.…”

Section: Introductionmentioning

confidence: 99%

Etomoxir, sodium 2‐[6‐(4‐chlorophenoxy)hexyl]oxirane‐2‐carboxylate, inhibits triacylglycerol depletion in hepatocytes and lipolysis in adipocytes

Spurway¹,

Pogson²,

Sherratt³

et al. 1997

FEBS Letters

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Section: Introductionmentioning

confidence: 99%

Etomoxir, sodium 2‐[6‐(4‐chlorophenoxy)hexyl]oxirane‐2‐carboxylate, inhibits triacylglycerol depletion in hepatocytes and lipolysis in adipocytes

Spurway¹,

Pogson²,

Sherratt³

et al. 1997

FEBS Letters

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“…(Svejgaard et al 1980, Deschamps et al 1980. These alleles belong to three major "high risk" haplotypes with a contrasted distribution in European populations (Cmntu et al 1982, Wolf et al 1982. The alleles of the complement factors Bf, C4A and C4B ("cornplo-types") are in linkage disequilibrium with HLA class I and I1 alleles leading to "extended haplotypes" observed in normal populations (Awdeh et al 1983) as well as in disease ), but their functional importance is not clear.…”

mentioning

confidence: 99%

Study of cis and trans interactions between extended HLA‐haplotypes in insulin‐dependent diabetes

et al. 1988

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From the study of HLA, A, B, C, DR, Bf and C4A, C4B alleles in 287 insulin-dependent diabetes mellitus patients and 108 controls, comparisons were made between 424 diabetic and 216 normal extended haplotypes. In the "cis" situation (haplotype), the highest relative risks (RR) for IDDM were borne by multiloci allelic associations, mainly DR/complement alleles, rather than by DR3 or DR4 considered alone. Susceptibility was strongly associated with two extended haplotypes (Aw30, Cw5, B18, C4BQ0, C4A3, BfF1, DR3 and A2, Cw3, B15, C4Bx, C4A3, BfS, DR4) or their smaller segments. Two haplotypes, S31 associated with DR2 or DR5 and F31 associated with DRw6 or DR7 had a protective effect. In the "trans" situation (opposite haplotype) the large excess of DR3/DR4 heterozygotes was not the only distortion observed. An excess of DR1 (57%) and of C4BQ0 (40%) was noted among non DR3, non DR4 haplotypes in diabetics compared to normal individuals (26% and 23%, respectively, P less than 0.01, 0.05). Homozygotes for DR3 or DR4 were not increased, and other homozygotes were decreased compared to controls. The protective antigens HLA DR2, DR5 and DR7 seemed not to be distributed randomly: their putative protective effect was not observed in the case of combination with DR1 or a B18, DR3 haplotype. DR2 was never found homozygous or combined with DR5. These results suggest that susceptibility to IDDM is generated by both cis and trans interactions between genes or gene products of the HLA region.

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“…Association of Bf allo types with HLA antigens has been well docu mented, and, more interestingly, the rare Bf allotypes BfFl and BfSl are often found on typical MHS haplotypes. Thus, BfFl occurs mainly with HLA-DR3 [3] and secondarily with HLA-B18 and Cw5 [7], BfSl occurs on haplotypes which also carry HLA-Bw50 [8] and HLA-DR7 [our unpublished observa tions].…”

Section: Controlsmentioning

confidence: 99%

Allotypes of Properdin Factor B(Bf) and Lymphocytotoxic Antibody Production

Davidson¹,

Dyer²

1984

Complement

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We have investigated the properdin factor B(Bf) polymorphism in relation to lymphocytotoxic antibody production. The Bf phenotypes of 1,113 individuals was determined; these consisted of 360 cytotoxic antibody-negative normal healthy controls, 293 HLA typing antisera, 330 sera from pregnant multiparous women, and 130 renal patients awaiting cadaveric transplantation. The allotype BfF was found to be strongly associated with cytotoxic antibody production in multiparous women.

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The Bf system in diabetes-gene interaction or linkage disequilibrium?

Cited by 3 publications

References 20 publications

Etomoxir, sodium 2‐[6‐(4‐chlorophenoxy)hexyl]oxirane‐2‐carboxylate, inhibits triacylglycerol depletion in hepatocytes and lipolysis in adipocytes

Etomoxir, sodium 2‐[6‐(4‐chlorophenoxy)hexyl]oxirane‐2‐carboxylate, inhibits triacylglycerol depletion in hepatocytes and lipolysis in adipocytes

Study of cis and trans interactions between extended HLA‐haplotypes in insulin‐dependent diabetes

Allotypes of Properdin Factor B(Bf) and Lymphocytotoxic Antibody Production

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