The bioartificial pancreas (BAP): Biological, chemical and engineering challenges

Iacovacci, Veronica; Ricotti, Leonardo; Menciassi, Arianna; Dario, P.

doi:10.1016/j.bcp.2015.08.107

Cited by 55 publications

(29 citation statements)

References 228 publications

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“…However, glucose sensors still have to be exchanged frequently. Ongoing approaches for the establishment of a bioartificial pancreas on the basis of stemcell-derived beta-cells or pancreatic islets from human or pig donors that restores physiological function of the endocrine pancreas (reviewed in [197]) could also be tested in INS C94Y transgenic pigs.…”

Section: Transgenic Pigs Expressing the Mutant Insulin C94ymentioning

confidence: 99%

Comparative aspects of rodent and nonrodent animal models for mechanistic and translational diabetes research

Renner

Dobenecker²,

Blutke³

et al. 2016

Theriogenology

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Section: Transgenic Pigs Expressing the Mutant Insulin C94ymentioning

confidence: 99%

Comparative aspects of rodent and nonrodent animal models for mechanistic and translational diabetes research

Renner

Dobenecker²,

Blutke³

et al. 2016

Theriogenology

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“…Advances in tissue engineering have facilitated the development of replacement organ tissues for the treatment of injured or degenerative soft tissue. The development of a bioengineered pancreas by appropriate combinations of cells, biomaterial scaffolds and biologically active molecules could provide an alternative avenue for DM therapy (Iacovacci et al 2016). Researchers examined the probability of producing an acellular complete pancreas scaffold via the perfusion, decellularization method and then using this biomaterial as a scaffold to upkeep pancreatic tissue engineering and entire organ regeneration.…”

Section: Tissue Engineering Of Pancreasmentioning

confidence: 99%

Concise Review: Β Cell Replacement Therapies in Treatment of Diabetes Mellitus

Somuncu

Çelik

Ergün

et al. 2019

Trakya University Journal of Natural Sciences

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Metabolic rate of glucose uptake is generally controlled by a feedback mechanism covering islet β cells and insulinsensitive tissues, wherein tissue sensitivity to insulin influences the level of β-cell comeback. In case of insulin presence, β cells preserve standard glucose tolerance via enhancing insulin production. Even though β-cell dysfunction has a strong hereditary component, environmental alterations carry an important part as well. Current research methods have facilitated to establish the important part of hexoses, amino acids, and fatty acids in the development of insulin resistance and β-cell dysfunction, therefore more operative treatments to slow the progressive loss of β-cell function are required. Latest discoveries from clinical research deliver significant information about approaches to stop and treat diabetes and some of the adversative properties of these interferences. Generation of satisfactory numbers of pancreatic endocrine cells that work in the same way as primary islets is of supreme prominence for the expansion of cell treatments to cure. In this study, we focused on different techniques starting from islet and pancreas transplantations individually and ending on new therapies such as stem cell technology and bioengineering. We aimed to establish a comprehensive and detailed explanation of treatment perspectives for islet cell loss. This review is carrying a novel potential for enlightening the current treatments and future-based therapies.

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“…As previously reported, the piezoelectric pressure sensor was designed to be integrated into an implantable artificial pancreas. Figure 2a depicts the preliminary prototype of the artificial organ [2] and the yellow circle defines the area where the pressure sensor must be located. As described in Figure 2a, the prototype comprises a refilling module, interfaced with intestine wall, able to dock an ingestible insulin capsule.…”

Section: Design and Fabrication Of The Piezoelectric Pressure Sensor mentioning

confidence: 99%

Fabrication of AlN-Based Flexible Piezoelectric Pressure Sensor to Integrate into an Artificial Pancreas

et al. 2018

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Present work reports the fabrication and characterization of a flexible AlN-based piezoelectric pressure sensor integrated, as insulin capsule punching detector, into an implantable artificial pancreas (AP), developed as automated treatment device for Type 1 diabetes. Ti/AlN/Ti trilayer was sputtered on a thin kapton substrate at room temperature, making the final device flexible and sensitive to the forces range of interest (0-4 N). The proposed preliminary prototype of AP comprises a refilling module, interfaced with the intestine wall, able to dock an ingestible insulin capsule. A linearly actuated needle punches the capsule to transfer the insulin to an implanted reservoir. The pressure sensor is located at the connection of the needle with the linear actuator to sense the occurred capsule punching. The sensor waveform output was processed to clearly identify the capsule punching.

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The bioartificial pancreas (BAP): Biological, chemical and engineering challenges

Cited by 55 publications

References 228 publications

Comparative aspects of rodent and nonrodent animal models for mechanistic and translational diabetes research

Comparative aspects of rodent and nonrodent animal models for mechanistic and translational diabetes research

Concise Review: Β Cell Replacement Therapies in Treatment of Diabetes Mellitus

Fabrication of AlN-Based Flexible Piezoelectric Pressure Sensor to Integrate into an Artificial Pancreas

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