The bioavailability of soy isoflavones in vitro and their effects on gut microbiota in the simulator of the human intestinal microbial ecosystem

Determination of 14 Isoflavone Isomers in Natto by UPLC-ESI-MS/MS and Antioxidation and Antiglycation Profiles

“…For the FRAP system, the antioxidant capacity for soybean isoflavones decreased as follows: genistein > daidzein > isoflavone sample exacted from natto > genistin > daidzin, indicating that antioxidant capacity depends on the functional moieties bound to 3-benzopyrone parent nucleus. Compared with the previous FRAP experiment, the antioxidant capacity of aglycones was consistent [ 35 ]. Additionally, in the present experiment, genistin showed a stronger antioxidant capacity than daidzin, which is consistent with the findings of previous studies [ 10 ].…”

Dietary polyphenols and their relationship to the modulation of non-communicable chronic diseases and epigenetic mechanisms: A mini-review

“… O -desmethylangolensin and equol Equol : ↓ methylation of the cytosine phosphate guanine (CpG) islands in the BRCA 1 and BRCA2 promoters in MCF-7 and MDA-MB-231 cells and ↑ BRCA1 and BRCA2 proteins expression in nuclei and cytoplasm in cell lines MCF-7, MDA-MB-231 and MCF-10a by immunohistochemistry. ( Bosviel et al, 2012 , Chen et al, 2022 ) Lignans ↑ Ruminococcaceae and Bacteroidetes ( Bacteroides and Rikenellaceae ), ↓ Coriobacteriaceae, especially Collinsella , and Streptococcus in premenopausal women. Pinoresinol, secoisolariciresinol, matairesinol, lariciresinol, isolariciresinol, and syringaresinol Pinoresinol : ↑ rate and the expression of collagen type I (Col‑I), ALP, osteopontin (OPN), runt‑related transcription factor 2 (Runx2) and bone morphogenetic protein‑2 (BMP‑2), ↑ ALP activity and Alizarin red size, and ↑ cAMP, PKA and phosphorylated cAMP response element‑binding protein (CREB) levels.…”

Flavonoids bridging the gut and the brain: Intestinal metabolic fate, and direct or indirect effects of natural supporters against neuroinflammation and neurodegeneration

“…Results confirmed that soy isoflavones are mainly digested in the colon, and their antioxidant capacity changes with the progression of digestion. Moreover, isoflavones can modify the composition of the gut microbiota by inhibiting the growth of harmful bacteria, and promote the growth of probiotics and significantly improve their antibacterial ability in vitro [122].…”