The biochemical and molecular mechanisms involved in the role of tumor micro-environment stress in development of drug resistance

Al-Akra, Lina; Bae, Dong-Hun; Leck, Lionel Yi Wen; Richardson, Des R.; Jansson, Patric J.

doi:10.1016/j.bbagen.2019.06.007

Cited by 30 publications

(21 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although some drugs and treatments have clinical significance, in the process of continuous treatment, some remaining cells continue to proliferate and, then, acquire drug resistance [154]. Autophagy which is essential to the efficacy of anticancer drugs, as well as drug resistance can have a prosurvival role in response to metabolic and therapeutic stresses [155]. Xia et al demonstrated that the mitotic kinase NEK2 is involved in the development of MDR by regulating autophagy in multiple myeloma (MM).…”

Section: The Pivotal Role Of Ulk In the Development Of Drug Resistancmentioning

confidence: 99%

“…The phosphorylation of ULK1 decreases the activity and stability of ULK1, thus, inhibiting autophagy and promoting resistance against temozolomide in glioma cells [159]. The treatment of tumors by targeting ULK, however, has presented many challenges in the intrinsic and acquired drug resistance in cancer treatments [155] (Figure 3).…”

Section: The Pivotal Role Of Ulk In the Development Of Drug Resistancmentioning

confidence: 99%

See 1 more Smart Citation

A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer

Liu

Liao

et al. 2020

Cancers

View full text Add to dashboard Cite

The difficulty of early diagnosis and the development of drug resistance are two major barriers to the successful treatment of cancer. Autophagy plays a crucial role in several cellular functions, and its dysregulation is associated with both tumorigenesis and drug resistance. Unc-51-like kinase 1 (ULK1) is a serine/threonine kinase that participates in the initiation of autophagy. Many studies have indicated that compounds that directly or indirectly target ULK1 could be used for tumor therapy. However, reports of the therapeutic effects of these compounds have come to conflicting conclusions. In this work, we reviewed recent studies related to the effects of ULK1 on the regulation of autophagy and the development of drug resistance in cancers, with the aim of clarifying the mechanistic underpinnings of this therapeutic target.

show abstract

Section: The Pivotal Role Of Ulk In the Development Of Drug Resistancmentioning

confidence: 99%

Section: The Pivotal Role Of Ulk In the Development Of Drug Resistancmentioning

confidence: 99%

A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer

Liu

Liao

et al. 2020

Cancers

View full text Add to dashboard Cite

show abstract

“…79,80 Some studies have also shown that autophagy-related proteins, such as Beclin 1 (BECN1), microtubule-associated protein1 light chain 3 (MAP1-LC3), and p62/sequestosome 1 (SQSTM1) have an important prognostic value in gastric cancer, and act as a protective mechanism for tumor cells in chemotherapy, promoting drug resistance as well. [81][82][83] The therapeutic induction of autophagy is frequently attributed to reduced mTOR activity leading to autophagy de-repression, and this is most obvious with therapies targeted at inhibiting PI3K, AKT or indeed mTOR itself. In addition, autophagy is induced by conventional genotoxic agents, such as radiation or cisplatin, as a result of DNA damageinduced p53 activity.…”

Section: Change Of Autophagy Pathwaysmentioning

confidence: 99%

<p>A Review of Research Progress in Multidrug-Resistance Mechanisms in Gastric Cancer</p>

Ruan¹,

Liu²,

Tao³

et al. 2020

OTT

View full text Add to dashboard Cite

Gastric cancer is one of the most common malignant tumors, and it is also one of the leading causes of cancer death worldwide. Because of its insidious symptoms and lack of early dictation screening, many cases of gastric cancer are at late stages which make it more complicated to cure. For these advanced-stage gastric cancers, combination therapy of surgery, chemotherapy, radiotherapy and target therapy would bring more benefit to the patients. However, the drug-resistance to the chemotherapy restricts its effect and might lead to treatment failure. In this review article, we discuss the mechanisms which have been found in recent years of drug resistance in gastric cancer. And we also want to find new approaches to counteract chemotherapy resistance and bring more benefits to the patients.

show abstract

“…Hypoxic conditions contribute to the reduced development of vessels within the tumor mass, thus causing a decreased drug amount in target sites and, consequently, drug efficacy. All these elements strongly suggest that TME plays a crucial role in cell response to chemo, radio and targeted therapies [ 16 ]. Another microenvironment factor that can contribute to tumor complexity and heterogeneity, and indirectly to therapy response, is represented by the presence of a population of tumor cells with stem features.…”

Section: Introduction: Limitations Of Anticancer Therapiesmentioning

confidence: 99%

Drug Delivery Systems of Natural Products in Oncology

Colone¹,

Calcabrini²,

Stringaro³

2020

Molecules

View full text Add to dashboard Cite

In recent decades, increasing interest in the use of natural products in anticancer therapy field has been observed, mainly due to unsolved drug-resistance problems. The antitumoral effect of natural compounds involving different signaling pathways and cellular mechanisms has been largely demonstrated in in vitro and in vivo studies. The encapsulation of natural products into different delivery systems may lead to a significant enhancement of their anticancer efficacy by increasing in vivo stability and bioavailability, reducing side adverse effects and improving target-specific activity. This review will focus on research studies related to nanostructured systems containing natural compounds for new drug delivery tools in anticancer therapies.

show abstract

The biochemical and molecular mechanisms involved in the role of tumor micro-environment stress in development of drug resistance

Cited by 30 publications

References 101 publications

A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer

A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer

<p>A Review of Research Progress in Multidrug-Resistance Mechanisms in Gastric Cancer</p>

Drug Delivery Systems of Natural Products in Oncology

Contact Info

Product

Resources

About