The biocompatibility and water uptake behavior of superparamagnetic poly(2-Hydroxyethyl methacrylate) - magnetite nanocomposites as possible nanocarriers for magnetically mediated drug delivery system

Gupta, Meher Kanta; Bajpai, Jaya; Bajpai, A. K.

doi:10.1007/s10965-014-0518-0

Cited by 15 publications

(10 citation statements)

References 29 publications

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“…Core/shell structure appeared in Fig. 4c, as a concentrated core and a lighter shell, in which magnetite nanoparticles appeared darker and well dispersed in the whole matrix of nanoparticle (Gupta et al 2014a, b). …”

Section: Resultsmentioning

confidence: 99%

“…Fe 2+ (0.5 M), Fe 3+ (1 M), and Fe 2+ /Fe 3+ (1:2 M), which facilitated an entrapment of different types of iron ions into the casein matrix; one contained only Fe 2+ ions, an other only Fe 3+ ions, and one had both Fe 3+ and Fe 2+ ions. Afterward, these particles were subjected to precipitation of iron oxide in alkaline medium (Gupta et al 2014a, b). Thus, it can be hypothesized that the CNPs containing only Fe 3+ and Fe 2+ ions lead to the formation of maghemite (c-Fe 2 O 3 ) and hematite (a-Fe 2 O 3 ) oxides of iron, whereas CNPs containing both Fe 2+ and Fe 3+ ions in the 1:2 molar ratio preferred the formation of magnetite (Fe 3 O 4 ).…”

Section: Resultsmentioning

confidence: 99%

“…The prepared nanoparticles were then washed, dried at room temperature and stored in airtight polyethylene bags. The percentage impregnation of iron oxide can be calculated using following equation (Gupta et al 2014a, b).

Impregnation false(% false) = \frac{W_{impregnated} - W_{dry}}{W_{dry}} \times 100

…”

Section: Introductionmentioning

confidence: 99%

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Designing casein-coated iron oxide nanostructures (CCIONPs) as superparamagnetic core–shell carriers for magnetic drug targeting

Singh¹,

Bajpai²,

Tiwari

et al. 2014

Prog Biomater

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Magnetic drug targeting is a drug delivery system applicable to cancer treatment. Coated magnetic particles, called carriers, are very useful for delivering chemotherapeutic drugs. In the present research, casein-coated iron oxide nanocarriers (CCIONPs) of core shell nanostructure have been described as being applicable to magnetic drug targeting. The structure, morphology, and composition of prepared magnetic nanoparticles were determined by analytical techniques like Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), Electron diffraction (ED), X-ray diffraction (XRD), Zeta potential, Dynamic light scattering (DLS), Mossbauer and Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), Vibrating sample magnetometery (VSM)) and in vitro cytotoxicity analysis. Magnetization studies of CCIONPs conducted at room temperature using a vibrating sample magnetometer suggested their superparamagnetic nature as having a saturation magnetization (Ms) of 64 emu g−1 at an applied magnetic field of 5 kOe. The size of the magnetic polymeric nanoparticles was found to lie in the range of 73.9 ±0.36 nm, and the particles exhibited superparamagnetic behavior. The prepared particles could be used as a drug carrier for controlled and targeted drug delivery.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Designing casein-coated iron oxide nanostructures (CCIONPs) as superparamagnetic core–shell carriers for magnetic drug targeting

Singh¹,

Bajpai²,

Tiwari

et al. 2014

Prog Biomater

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“…33,34 In addition, by incorporation of above mentioned polymers into PANI backbone it is possible to obtain conductive and biocompatible materials that can be soluble in water and some organic solvents. 33,34 In addition, by incorporation of above mentioned polymers into PANI backbone it is possible to obtain conductive and biocompatible materials that can be soluble in water and some organic solvents.…”

Section: Resultsmentioning

confidence: 99%

Soluble and electrically conductive polyaniline‐modified polymers: Incorporation of biocompatible polymeric chains through ATRP technique

Massoumi

Shafagh-kalvanagh

Jaymand³

2017

J of Applied Polymer Sci

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This article describes the incorporation of biocompatible polymeric chains [poly(2-hydroxyethyl methacrylate) and poly(N-isopropylacrylamide)] into the polyaniline backbone through atom transfer radical polymerization technique to produce soluble and electrically conductive polyaniline-based materials. The chemical structures of all samples as representatives were characterized by means of Fourier transform-infrared and proton nuclear magnetic resonance spectroscopies. The electroactivity behaviors and electrical conductivities of the synthesized samples were verified under cyclic voltammetric conditions, and the standard four-probe method, respectively. In addition, the thermal behaviors and morphologies of the synthesized samples were investigated by means of thermogravimetric analysis and scanning electron microscopy, respectively. We envision that the synthesized polyaniline-modified polymers may be find applications in biomedical fields such as tissue engineering, mainly due to their water solubilities, electrical conductivities, and biocompatibilities.

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“…Acrylamide and AAc-based polymers interact with many metal cations, including hematite in hydrous solutions [41]. Due to the porous structure of hydrogels and the existence of amide (CONH 2 ) and carboxylic (COOH) groups in the main chains, the acrylamide and AAc hydrogels easily bind to the iron (II) and iron (III) cations in aqueous mixed solutions of iron (II) chloride tetrahydrate and iron (III) chloride hexahydrate mixtures via electrostatic interactions.…”

Section: Preparation Of Magnetic Nanopolymersmentioning

confidence: 99%

Removal of heavy metal ions from aqueous solutions by radiation‐induced chitosan/(acrylamidoglycolic acid‐co‐acrylic acid) magnetic nanopolymer

Fadl

El‐Mohdy

2015

Polymer Engineering & Sci

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An effective method was developed to isolate toxic heavy metal ions from the aqueous solution by the magnetic nanopolymers. The magnetic sorbent was prepared with radiation-induced crosslinking polymerization of chitosan (CS), 2-acrylamido-glycolic acid (AMGA), and acrylic acid (AAc), which stabilized by magnetite (Fe 3 O 4 ) as nanoparticles. The formation of magnetic nanoparticles (MNPs) into the hydrogel networks was confirmed by Fourier transform infrared spectroscopy, X-ray diffraction, transmission electron microscopy, and Scanning electron microscopy, which revealed the formation of MNPs throughout the hydrogel networks. The swelling behavior of the hydrogels and magnetic ones was evaluated at different pH values. The adsorption activity for heavy metals such as Cu 21 and Co 21 by nonmagnetic and magnetic hydrogels, Fe 3 O 4 /CS/ (AMGA-co-AAc), in terms of adsorption amount was studied. It was revealed that hydrogel networks with magnetic properties can effectively be used in the removal of heavy metal ions pollutants and provide advantageous over conventional ones.

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The biocompatibility and water uptake behavior of superparamagnetic poly(2-Hydroxyethyl methacrylate) - magnetite nanocomposites as possible nanocarriers for magnetically mediated drug delivery system

Cited by 15 publications

References 29 publications

Designing casein-coated iron oxide nanostructures (CCIONPs) as superparamagnetic core–shell carriers for magnetic drug targeting

Designing casein-coated iron oxide nanostructures (CCIONPs) as superparamagnetic core–shell carriers for magnetic drug targeting

Soluble and electrically conductive polyaniline‐modified polymers: Incorporation of biocompatible polymeric chains through ATRP technique

Removal of heavy metal ions from aqueous solutions by radiation‐induced chitosan/(acrylamidoglycolic acid‐co‐acrylic acid) magnetic nanopolymer

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