The present study aims at formulating a novel multifunctional biocompatible superparamagnetic nanoparticles carrier system with homogeneously dispersed magnetic material in solid polymer matrix of poly(2‐hydroxyethyl methacrylate) (PHEMA). The nanocomposites were designed by modified suspension polymerization of 2‐hydroxyethyl methacrylate followed by in situ coprecipitation of iron oxide inside the nanoparticle matrix yielding magnetic PHEMA (mPHEMA) nanocomposites. The so prepared nanocomposites were characterized by Fourier transform Infrared spectroscopy, X‐ray diffraction technique, Raman spectroscopy, electron diffraction, and energy‐dispersive X‐ray spectroscopy confirming the presence of Fe3O4 inside the PHEMA nanoparticles. The magnetization studies of nanocomposites conducted at room temperature using vibrating sample magnetometer suggested for their superparamagnetic nature having saturation magnetization (Ms) of 20 emu/g at applied magnetic field of 5 kOe. Transmission electron microscopy, field‐emission scanning electron microscopy, and dynamic light scattering/zeta potential measurements were also performed which revealed that size of mPHEMA nanocomposites was lying in the range of 60–300 nm having zeta potential of −93 mV. The nanocomposites showed no toxicity as revealed by cytotoxicity test performed on L‐929 fibroblast by extract method. The results indicated that the prepared superparamagnetic mPHEMA nanocomposites have enormous potential to provide a possible option for magnetically assisted targeted delivery of anticancer drugs. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40791.

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Superparamagnetic nanocarriers of poly (2-hydroxyethyl methacrylate) (PHEMA) were prepared by carrying out benzoyl peroxide (BPO) initiated inverse emulsion-free radical polymerization of HEMA in the presence of poly (vinyl alcohol) (PVA) and subsequent in situ precipitation of magnetite within the PHEMA matrix. The as-prepared nanoparticles were characterized by FTIR and UV-visible spectroscopy, vibrating sample magnetometry (VSM), particle size and zeta potential analysis, and transmission electron microscopy, respectively. The PHEMA nanocarriers were investigated for their blood compatibility, and cytotoxicity response to L929 cells. The superparamagnetic nanoparticles were loaded with an anticancer drug cisplatin and the release profiles of the drug were examined as a function of various experimental parameters like composition of the PHEMA nanocarriers, percentage of drug loading, and strength of the externally imposed magnetic field. The kinetics of the drug release process was also investigated, and the obtained release data were applied to different mathematical kinetic models to explore the nature of the release mechanism.

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SynopsisWe have demonstrated the utility of dyeing techniques, using Solophenyl Fast Blue Green BL, to characterize a variety of regenerated cellulosic films. Measurement of the optical density ratio and the rate and magnitude of dye uptake show that differences in structure exist in regenerated cellulose films processed under different conditions. These differences are attributed to differences in lateral order and orientation of cellulose chains and are believed similar to the so-called skin and core observed in rayon fibers. These differences have been found related reproducibly to differences in regenerating and processing conditions. Diffusion of dye into a film is very rapid initially, slowing later to an almost constant rate, depending on the dye concentration in solution and on the type of film. A modified diffusion equation of the form In C/CO -(1 -C/C@) = Dy2-tCo/C, has been found adequate to express the non-steady state of the observed absorption process, where Co is the initial dye concentration of the test solution, C is the instantaneous dye concentration a t time t, C, is the dye concentration in the film, y2 is the area of film per unit volume of dye solution, and D is the diffusion coefficient. Thus, a mathematical basis is provided for structural differentiation in cellulosic films processed in various ways. Plate-cast viscose films appear to have a dense surface (skin) exposed i,o the regenerating bath and a porous surface (core) on the side touching the plate, whereas machine-cast viscose films have a dense surface on both sides.Study of the crystallinity and orientation of rayon fibers has greatly contributed to an understanding of the relationship between processing conditions and fiber properties, especially in the development of very strong fibers in recent years. In this report we describe a similar study of fine structure of regenerated cellulose films which was undertaken with a similar purpose : to relate and interpret the interdependence of processiiig variables, fine structure, and physical characteristics of the finished films.Our approach has been to use a modification of the dye staining technique of Voss' and that used in the laboratories of International Cellulose Research, Ltd., Hawkesbury, Ontario. Measurements of optical density of