The biocompatibility of crosslinkable copolymer coatings containing sulfobetaines and phosphobetaines

Raman spectroscopic study on the structure of water in aqueous solution of -amino acids

“…Meanwhile, a thin film composed of the copolymer of MPC and BMA has been reported to have excellent bloodcompatibility [17,18]. A similar tendency was observed for a copolymer of BMA and SPB [19].…”

Resistance of zwitterionic telomers accumulated on metal surfaces against nonspecific adsorption of proteins

“…Quire recently, it has been reported that a thin film of phosphobetaine polymer is more biocompatible than one of sulfobetaine polymer [105]. Though the authors of that report claimed that the tertiary amino group in the N,N-dimethylaminoethyl methacrylate residue of the precursor polymer was completely converted to sulfobetaine group, we could not pursue the quaternization of N ,N -dimethylaminopropyl methacrylamide residue (DMAPMA) in poly-DMAPMA completely.…”

Ultralow‐Fouling, Functionalizable, and Hydrolyzable Zwitterionic Materials and Their Derivatives for Biological Applications

“…[32,43,58,59] The ''graft-to'' method involves (i) the preparation of polymers containing nonfouling and adhesive groups, such as 3,4-dihydroxyphenylalanine (DOPA) groups [24,60] and polylysine segments, [61] and (ii) the direct attachment of the polymers onto the surface. pSB and pCB have been grafted to or from surfaces via several common adhesive linkers, including thiols for a gold surface, [43,45,47,50,51,62,63] silanes for a glass surface, [64] hydrophobic moieties for a hydrophobic surface, [41,65,66] or DOPA for various surfaces, [67,68] or via interpenetrating networks (IPNs) into polyurethane (SPU) matrices. [69] pSB-based hydrogels have also been prepared.…”

“…[36,[38][39][40] In previous studies, sulfobetaine polymers were thought to be less fouling-resistant than phosphobetaine polymers. [41] Since sulfobetaines were attached onto hydrophobic substrates via sulfobetaine-hydrophobic diblock copolymers, it was harder to achieve high surface packing densities of sulfobetaine groups. In other studies, [42] SB was grafted onto a segmented poly(ether urethane) (SPEU) surface via free-radical polymerization and it was shown that platelet adhesion on the more hydrophilic surface modified by SB was reduced as compared to that on its unmodified hydrophobic surface.…”