The Biodistribution of Boron in Canine Spontaneous Intracranial Tumors Following Borocaptate Sodium Infusion

Kraft, Susan L.; Gavin, Patrick R.; DeHaan, C. E.; Leathers, C. W.; Bauer, William F.; DornIII, Ronald V.

doi:10.1007/978-1-4615-3384-9_118

Cited by 10 publications

(5 citation statements)

References 2 publications

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“…Preliminary translational studies in dogs with a variety of intracranial tumors demonstrated the feasibility of the approach and anecdotal therapeutic successes with and without surgical cytoreduction. 192,193 Although availability of equipment is limiting, recent advances in more tumor-selective boron delivery drugs may improve the limited clinical efficacy and toxicity (eg, radiation necrosis) in the future. 194…”

Section: Radiation Therapymentioning

confidence: 99%

Advances in Diagnostic and Treatment Modalities for Intracranial Tumors

Dickinson

2014

Veterinary Internal Medicne

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Intracranial neoplasia is a common clinical condition in domestic companion animals, particularly in dogs. Application of advances in standard diagnostic and therapeutic modalities together with a broad interest in the development of novel translational therapeutic strategies in dogs has resulted in clinically relevant improvements in outcome for many canine patients. This review highlights the status of current diagnostic and therapeutic approaches to intracranial neoplasia and areas of novel treatment currently in development.

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Section: Radiation Therapymentioning

confidence: 99%

Advances in Diagnostic and Treatment Modalities for Intracranial Tumors

Dickinson

2014

Veterinary Internal Medicne

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“…In another publication, the authors reported higher mean boron accumulation in extracranial compared to intracranial spontaneous tumors in dogs with maximum levels at 2 h after BSH infusions of the same dose as their previous report. They then described variations in tumor-to-blood and peritumor boron concentrations, suggesting further pharmacokinetic studies to evaluate whether intracranial surgeries can influence BSH pharmacokinetics [ 94 ].…”

Section: Discussionmentioning

confidence: 99%

In Vivo Accelerator-Based Boron Neutron Capture Therapy for Spontaneous Tumors in Large Animals: Case Series

Kanygin

Кичигин

Zaboronok

et al. 2022

Biology

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(1) Background: accelerator-based neutron sources are a new frontier for BNCT but many technical issues remain. We aimed to study such issues and results in larger-animal BNCT (cats and dogs) with naturally occurring, malignant tumors in different locations as an intermediate step in translating current research into clinical practice. (2) Methods: 10 pet cats and dogs with incurable, malignant tumors that had no treatment alternatives were included in this study. A tandem accelerator with vacuum insulation was used as a neutron source. As a boron-containing agent, 10B-enriched sodium borocaptate (BSH) was used at a dose of 100 mg/kg. Animal condition as well as tumor progression/regression were monitored. (3) Results: regression of tumors in response to treatment, improvements in the overall clinical picture, and an increase in the estimated duration and quality of life were observed. Treatment-related toxicity was mild and reversible. (4) Conclusions: our study contributes to preparations for human BNCT clinical trials and suggests utility for veterinary oncology.

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“…Dogs have previously been used in BNCT-related studies to evaluate the RBE of an epithermal beam for brain tissue [ 36 ], the tolerance of normal canine brain to epithermal neutron irradiation in the presence of BPA [ 37 ], and normal tissue tolerance with BNCT mediated by sodium borocaptate (BSH) [ 38 , 39 ]. Kraft et al [ 40 , 41 ] used dogs with spontaneous brain tumors to evaluate BSH biodistribution and implications for BSH-mediated BNCT. These authors stressed the relevance of studying spontaneous tumors as opposed to experimental tumors.…”

Section: Discussionmentioning

confidence: 99%

Clinical Veterinary Boron Neutron Capture Therapy (BNCT) Studies in Dogs with Head and Neck Cancer: Bridging the Gap between Translational and Clinical Studies

Schwint

Hughes

Garabalino

et al. 2020

Biology

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Translational Boron Neutron Capture Therapy (BNCT) studies performed by our group and clinical BNCT studies worldwide have shown the therapeutic efficacy of BNCT for head and neck cancer. The present BNCT studies in veterinary patients with head and neck cancer were performed to optimize the therapeutic efficacy of BNCT, contribute towards exploring the role of BNCT in veterinary medicine, put in place technical aspects for an upcoming clinical trial of BNCT for head and neck cancer at the RA-6 Nuclear Reactor, and assess the feasibility of employing the existing B2 beam to treat large, deep-seated tumors. Five dogs with head and neck cancer with no other therapeutic option were treated with two applications of BNCT mediated by boronophenyl-alanine (BPA) separated by 3–5 weeks. Two to three portals per BNCT application were used to achieve a potentially therapeutic dose over the tumor without exceeding normal tissue tolerance. Clinical and Computed Tomography results evidenced partial tumor control in all cases, with slight-moderate mucositis, excellent life quality, and prolongation in the survival time estimated at recruitment. These exploratory studies show the potential value of BNCT in veterinary medicine and contribute towards initiating a clinical BNCT trial for head and neck cancer at the RA-6 clinical facility.

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The Biodistribution of Boron in Canine Spontaneous Intracranial Tumors Following Borocaptate Sodium Infusion

Cited by 10 publications

References 2 publications

Advances in Diagnostic and Treatment Modalities for Intracranial Tumors

Advances in Diagnostic and Treatment Modalities for Intracranial Tumors

In Vivo Accelerator-Based Boron Neutron Capture Therapy for Spontaneous Tumors in Large Animals: Case Series

Clinical Veterinary Boron Neutron Capture Therapy (BNCT) Studies in Dogs with Head and Neck Cancer: Bridging the Gap between Translational and Clinical Studies

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