The Biogenesis and Functions of circRNAs and Their Roles in Breast Cancer

Tang, Liting; Baohong, Jiang; Zhu, Hongbo; Gao, Ting; Zhou, Yu; Gong, Fuqiang; He, Rongfang; Xie, Liming; Li, Yuehua

doi:10.3389/fonc.2021.605988

Cited by 17 publications

(10 citation statements)

References 97 publications

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“…Recent years, numerous of circRNAs have been proved to participate in the tumorigenesis and progression of multiple cancers, including BC [ 23 , 24 ]. Different from linear non-coding RNAs, circRNAs are a group of highly conservative and stable RNAs formed by back splicing [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

EIF4A3-mediated circPRKCI expression promotes triple-negative breast cancer progression by regulating WBP2 and PI3K/AKT signaling pathway

et al. 2022

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Triple-negative breast cancer (TNBC) is known as a highly aggressive subtype of BC due to high rate of recurrence and metastasis, poor prognosis and lacking of effective targeted therapies. Circular RNAs (circRNAs) have been reported to participate in the progression of TNBC. In this study, we demonstrated that circPRKCI, derived from the PRKCI gene, was elevated in BC tissues and cell lines, especially in TNBC. The functional investigation showed that circPRKCI could significantly promote the proliferation and migration of TNBC in vivo and in vitro. In addition, circPRKCI regulated WBP2 and the phosphorylation of AKT via serving as miR-545-3p sponge. Of note, EIF4A3 could induce circPRKCI expression and nuclear export in TNBC cells. Taken together, EIF4A3-mediated circPRKCI could promote TNBC progression by regulating WBP2 and PI3K/AKT signaling pathway, providing a new avenue of therapy for TNBC.

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Section: Discussionmentioning

confidence: 99%

EIF4A3-mediated circPRKCI expression promotes triple-negative breast cancer progression by regulating WBP2 and PI3K/AKT signaling pathway

et al. 2022

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“…We only demonstrated that circEPSTI1 is a miRNA sponge. A large number of studies have confirmed that circRNAs have other roles such as communication with RNA-binding proteins (RBPs) [34], translation of proteins or peptides [36], and transcription regulation [37] that eventually produce a variety of different biological effects involved in the regulation of tumor cells, tumor microenvironment, angiogenesis, tumor immunity, and more [38]. In this study, we have elucidated the ability of circRNA as a miRNA sponge to promote the proliferation, migration, and invasion of HER2positive breast cancer cells via targeting ERBB3.…”

Section: Discussionmentioning

confidence: 99%

CircEPSTI1 Promotes the Proliferation of HER2-Positive Breast Cancer Cells via circEPSTI1/miR-145/ERBB3 Axis

Zhang

Tan

Xie

et al. 2022

Journal of Oncology

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Breast cancer is the most common type of cancer worldwide. There are great challenges in the prevention and treatment of breast cancer. In this study, we explored the molecular and biological mechanisms of circular RNA circEPSTI1 (has_circ_0000479) in the regulation of HER2-positive breast cancer cells. The expression of CircEPSTI1, microRNA miR-145, and ERBB3 in HER2-positive breast cancer cells was evaluated by qRT-PCR and western blot assays. Cell proliferation was assessed by CCK-8. Wound-healing and transwell migration assays were performed to evaluate cell migration. A transwell invasion assay was performed to detect cell invasion. The interaction of miR-145, circEPSTI1, and ERBB3 was confirmed bydual-luciferase reporter and RIP assays. CircEPSTI1 was upregulated in the HER2-positive breast cancer tissues and cells. Knockdown of circEPSTI1 inhibited SKBR3 and BT474 cell proliferation, migration, and invasion. Mechanistically, circEPSTI1 directly targeted miR-145, and miR-145 was a downstream mediator of circEPSTI1 in modulating the proliferation, migration, and invasion of SKBR3 and BT474 cells. ERBB3 was identified as a direct and functional target of miR-145 in HER2-positive breast cancer cells. Our findings demonstrate that circEPSTI1, an overexpressed circRNA in HER2-positive breast cancer, promotes the proliferation, migration, and invasion of SKBR3 and BT474 cells through the miR-145/ERBB3 axis.

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“…Genetic and epigenetic factors are the main ones [38,39]. Multiple recent studies have confirmed that circRNAs play a substantial role in the initiation and progression of various cancers, such as hepatic and renal carcinoma, and bladder, prostate, esophageal, breast, gastric and lung cancer [40][41][42][43][44][45]. Considerable evidence shows that these circRNAs function in a great number of cancers and play essential roles in their occurrence and development [46].…”

Section: Circrnas In Cancermentioning

confidence: 99%

CircRNAs as potent biomarkers in ovarian cancer: a systematic scoping review

et al. 2021

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More powerful prognostic and diagnostic tools are urgently needed for identifying and treating ovarian cancer (OC), which is the most fatal malignancy in women in developed countries. Circular RNAs (circRNAs) are conservative and stable looped molecules that can regulate gene expression by competing with other endogenous microRNA sponges. This discovery provided new insight into novel methods for regulating genes that are involved in many disorders and cancers. This review focuses on the dysregulated expression of circRNAs as well as their diagnostic and prognostic values in OC. We found that studies have identified twenty-one downregulated circRNAs and fifty-seven upregulated ones. The results of these studies confirm that circRNAs might be potent biomarkers with diagnostic, prognostic and therapeutic target value for OC. We also consider the connection between circRNAs and OC cell proliferation, apoptosis, metastasis, and chemotherapy resistance and sensitivity.

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The Biogenesis and Functions of circRNAs and Their Roles in Breast Cancer

Cited by 17 publications

References 97 publications

EIF4A3-mediated circPRKCI expression promotes triple-negative breast cancer progression by regulating WBP2 and PI3K/AKT signaling pathway

EIF4A3-mediated circPRKCI expression promotes triple-negative breast cancer progression by regulating WBP2 and PI3K/AKT signaling pathway

CircEPSTI1 Promotes the Proliferation of HER2-Positive Breast Cancer Cells via circEPSTI1/miR-145/ERBB3 Axis

CircRNAs as potent biomarkers in ovarian cancer: a systematic scoping review

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